Aim: While it is recommended that the ventrogluteal (VG) region is safer for intramuscular (IM) injection administration, we have observed that nurses mainly prefer the dorsogluteal (DG) region. Accordingly, the present study was carried out to examine the reasons for the nurses not to prefer the VG region in IM injection administrations. Material and Method: This descriptive study comprised 100 nurses working in a university hospital in the Konya province between June and July 2018. A questionnaire form was used to collect data. In order to be able to carry out the study, written institutional consent, ethics committee approval, and the verbal consent of participants were received. The SPSS packaged software was used for evaluation of the data, and number, percentage, and mean values were calculated in analyzing the data. Findings: It was seen that of the nurses participating in the study, the average age was 31.96±6.94, the average working year was 10.41±6.18, 75% were female, 53% held a bachelor's degree, 50% worked in internal medicine clinics, 84% used the DG region for IM injections, and 72% never administered an injection to the VG region. It was also determined that the nurses did not use the VG region because they were unaccustomed to it (40%), lacked enough information about the region (33%), could not identify the region (31%), and the patients were unaccustomed to IM injections administered in that region (30%). Conclusion: Nurses use the traditional region DG more because of a lack of knowledge and experience of the VG region.