Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training

Olsen, Steen; Aagaard, Per; Kadi, Fawzi; Tufekovic, Goran; Verney, Julien; Olesen, Jes; Suetta, Charlotte; Kjær, Michael

doi:10.1113/jphysiol.2006.107359

Cited by 269 publications

(212 citation statements)

References 38 publications

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“…Furthermore, maternal creatine supplementation did not affect urinary or plasma parameters in the spiny mouse neonate. Changes in water balance, mainly water retention, have been reported for creatine supplementation in adult humans (28), but the dose used here was clearly not sufficient to produce such effects, as no change in neonatal urine osmolality was observed following maternal creatine supplementation.…”

Section: Maternal Creatine Supplementationmentioning

confidence: 69%

Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney

et al. 2012

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Background: acute kidney injury (aKI) is a major complication for infants following an asphyxic insult at birth. We aimed to determine if kidney structure and function were affected in an animal model of birth asphyxia and if maternal dietary creatine supplementation could provide an energy reserve to the fetal kidney, maintaining cellular respiration during asphyxia and preventing aKI. Methods: Pregnant spiny mice were maintained on normal chow or chow supplemented with creatine from day 20 gestation. On day 38 (term ~39 d), pups were delivered by cesarean section (c-section) or subjected to intrauterine asphyxia. Twenty-four hours after insult, kidneys were collected for histological or molecular analysis. Urine and plasma were also collected for biochemical analysis. results: aKI was evident at 24 h after birth asphyxia, with a higher incidence of shrunken glomeruli (P < 0.02), disturbance to tubular arrangement, tubular dilatation, a twofold increase (P < 0.02) in expression of Ngal (early marker of kidney injury), and decreased expression of the podocyte differentiation marker nephrin. Maternal creatine supplementation prevented the glomerular and tubular abnormalities observed in the kidney at 24 h and the increased expression of Ngal. conclusion: Maternal creatine supplementation may prove useful in ameliorating kidney injury associated with birth asphyxia.

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Section: Maternal Creatine Supplementationmentioning

confidence: 69%

Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney

et al. 2012

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“…In addition, endurance (97,98,(104)(105)(106)(107)(108)(109)(110) exercise was shown to enhance the skeletal muscle oxidative capacity, resulting in greater endurance capacity (5,120) . Although the muscle regenerative capacity seems to decline at a more advanced age, the reduced satellite cell pool size (119) does not compromise the capacity for muscle hypertrophy to occur even at an advanced age (121)(122)(123) and resistance exercise training was shown to increase muscle fibre size (124)(125)(126)(127) . Recently, Verdijk et al (119) assessed the effects of 12 weeks of leg resistance exercise training on fibre-type specific hypertrophy and satellite cell content in healthy, elderly men.…”

Section: Long-term Interventionsmentioning

confidence: 99%

Dietary protein and exercise training in ageing

Koopman

2010

Proc. Nutr. Soc.

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Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk for developing chronic metabolic diseases such as diabetes. The age-related loss of skeletal muscle mass results from a chronic disruption in the balance between muscle protein synthesis and degradation. As basal muscle protein synthesis rates are likely not different between healthy young and elderly human subjects, it was proposed that muscles from older adults lack the ability to regulate the protein synthetic response to anabolic stimuli, such as food intake and physical activity. Indeed, the doseresponse relationship between myofibrillar protein synthesis and the availability of essential amino acids and/or resistance exercise intensity is shifted down and to the right in elderly human subjects. This so-called 'anabolic resistance' represents a key factor responsible for the age-related decline in skeletal muscle mass. Interestingly, long-term resistance exercise training is effective as a therapeutic intervention to augment skeletal muscle mass, and improves functional performance in the elderly. The consumption of different types of proteins, i.e. protein hydrolysates, can have different stimulatory effects on muscle protein synthesis in the elderly, which may be due to their higher rate of digestion and absorption. Current research aims to elucidate the interactions between nutrition, exercise and the skeletal muscle adaptive response that will define more effective strategies to maximise the therapeutic benefits of lifestyle interventions in the elderly. Sarcopenia: Nutrition: Exercise training: Muscle hypertrophyThe preservation of muscle function is crucial for maintaining an independent lifestyle and the capacity to perform the activities of daily living in the elderly. One of the important factors in the loss of functional performance is the progressive loss of skeletal muscle mass with ageing, called 'sarcopenia' (1)(2)(3) . This apparent muscle wasting in elderly human subjects occurs at a rate of about 0 . 5-1 . 0% per year starting at about 40 years of age. Lean muscle mass contributes up to about 50% of the total body mass of young adults but can decline to 25% by 75-80 years of age (4,5) . The loss of muscle mass is most notable in the lower limb muscles, with the cross-sectional area of the vastus lateralis reduced by as much as 40% at the age of 80 years (6) . Sarcopenia is associated with a three-to fourfold increased likelihood of disabilities and the loss of muscle mass especially in the lower limbs is associated with an increased risk of falls and impairment in the ability to perform routine activities.The loss of muscle mass is viewed as a largely inevitable and undesirable consequence of ageing (7) , with muscle loss estimated to affect 30% of people older than 60 years and >50 % of those older than 80 years (1) . Demographic studies indicate that the world's population aged 60 years and above will triple within the next 50 years, and the su...

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“…Estes indicam que a suplementação de creatina aumenta o peso corporal na primeira semana de carregamento de creatina devido à sua característica osmótica 1,6,[11][12][13] . Contudo, estudiosos questionam se as mudanças nos conteúdos intracelulares de água podem influenciar a tradução de proteínas contráteis e justificar parte do real ganho de massa magra 5,14,15 .…”

Section: Introductionunclassified

Creatina e treinamento resistido: efeito na hidratação e massa corporal magra

Zanelli

Cordeiro

Beserra

et al. 2015

Rev Bras Med Esporte

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RESUMOIntrodução: a creatina é um recurso ergogênico cuja suplementação tem sido associada ao aumento da hidratação corporal total e ao aumento da massa muscular dos consumidores. Entretanto, estudiosos questionam se o aumento da massa muscular é um ganho real. Objetivo: avaliar o efeito da suplementação de creatina sobre a hidratação e o aumento de massa magra em indivíduos previamente treinados e não treinados, submetidos a um programa de treinamento resistido. Métodos: ensaio clínico não randomizado, constituído por três momentos, M1 -Início da suplementação com 20g/dia de creatina; M2 -7 dias após iniciada a suplementação e redução da suplementação para 5g/dia; M3 -28 dias de suplementação. Nos momentos propostos, foram realizadas aferições de peso, estatura e avaliação da composição corporal (massa magra, água corporal total) com a utilização do BYODINAMICS® Modelo 310. Para todos os testes estatísticos, foi adotado o nível de significância de 95% (p<0,05). Resultados: participaram desse estudo 14 voluntários adultos do sexo masculino, com idade média de 22,57(±1,45) anos, dos quais sete eram treinados e sete não treinados. Após 28 dias de suplementação, no grupo treinado observou-se um aumento significativo no peso, água corporal total, massa magra e hidratação da massa magra, mas nenhum aumento significativo foi observado no grupo não treinado. Em relação ao ângulo de fase, este aumentou no grupo não treinado e reduziu no grupo treinado. Conclusão: a suplementação de creatina associada ao treinamento resistido é mais efetiva na hidratação de indivíduos treinados, como também é suficiente para reduzir a diferença significativa do ângulo de fase intergrupos, sugerindo assim, maior hidratação celular em ambos os grupos. Contudo, esse aumento na hidratação não revelou aumento significativo no tecido muscular. Palavras

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Creatine supplementation augments the increase in satellite cell and myonuclei number in human skeletal muscle induced by strength training

Cited by 269 publications

References 38 publications

Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney

Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney

Dietary protein and exercise training in ageing

Creatina e treinamento resistido: efeito na hidratação e massa corporal magra

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