Creatine@SiO₂@Fe₃O₄ nanocomposite as an efficient sorbent for magnetic solid‐phase extraction of escitalopram and chlordiazepoxide from urine samples through quantitation via HPLC–UV

Abstract

rent study to prepare magnetic nanoparticles covered by cheap and nitrogen-rich creatine. The hydrothermal method was used for the synthesis of the magnetic core. The prepared magnetic core was then covered by SiO 2 and subsequently functionalized using creatine. The prepared creatine@SiO 2 @Fe 3 O 4 was utilized as a sorbent in the magnetic solid-phase extraction of the selected antidepressants including escitalopram and chlordiazepoxide as the model drugs. The extracted drugs were desorbed by a suitable organic solvent and analyzed by high-performance liquid chromatography equipped with an ultraviolet detection system. The influence of different variables on the magnetic solid-phase extraction method was examined by the Plackett-Burman and Box-Behnken designs for screening and optimization, respectively. Under the obtained optimum conditions, the linear ranges of the method were found to be in the range of 1-500 µg L -1 . The limits of detection and limits of quantification were in the range of 0.27-0.63 µg L -1 and 0.89-1.93 µg L -1 for the selected analytes, respectively. Furthermore, the enrichment factors were found to be 79.8 and 92.7 for chlordiazepoxide and escitalopram, respectively. The method was successfully employed for the analysis of selected drugs in urine samples.

Magnetic solid‐phase extraction of warfarin and gemfibrozil in biological samples using polydopamine‐coated magnetic nanoparticles via core‐shell nanostructure

“…The developed method has low LODs and wide linear ranges. The overall results confirmed that our proposed method is simple, easy, relatively fast, repeatable, and sensitive [16, 18–26].…”

“…The overall results confirmed that our proposed method is simple, easy, relatively fast, repeatable, and sensitive [16,[18][19][20][21][22][23][24][25][26].…”

“…Warfarin is a derivative of coumarin [17]. This drug prevents the formation of blood clots in veins and arteries and is very useful in treating cardiovascular diseases [18]. Warfarin causes anticoagulant effects by reducing the synthesis of coagulation factors dependent on vitamin K, and the use of this drug in high concentrations causes fatal bleeding [19].…”

Green synthesis and characterization of NiFe2O4@ZnMn2O4 magnetic nanocomposites: An efficient and reusable spinel nanocatalyst for the synthesis of tetrahydropyrimidine and polyhydroquinoline derivatives under microwave irradiation

“…These MNCs exhibit distinct physical and chemical properties arising from the synergistic interactions between the different constituent metals 11,12 . Furthermore, an additional beneficial characteristic is the ability of the nanocatalyst to be easily recovered through the utilization of an external magnet, owing to its magnetic properties 13,14 . This approach effectively decreases the operational expenses and potentially facilitates the convenient reutilization of the catalyst.…”

Design of experiments (DoE) to develop and to optimize extraction of psychoactive substances

“…14 With MSPE, the target analytes are conveniently separated by the assistance of a magnetic eld, without the need for additional centrifugation or ltration steps, simplifying the pretreatment process and improving the extraction efficiency. 15 MSPE is frequently used for the extraction of pollutants from wastewater, chemicals derived from synthetic organic pollutants, pesticides, therapeutic medications, and heavy metal ions [16][17][18][19][20] due to its convenience, quick extraction process, good reusability, and environmental friendliness.…”