Magnetic solid‐phase extraction of warfarin and gemfibrozil in biological samples using polydopamine‐coated magnetic nanoparticles via core‐shell nanostructure

Abstract

Herein, polydopamine-coated Fe 3 O 4 spheres were synthesized using a very simple, easy, cost-effective, efficient, and fast method. First, magnetic nanoparticles (Fe 3 O 4 ) were synthesized and were followed by accommodating polydopamine on the surface of the prepared Fe 3 O 4 . The prepared polydopamine-coated Fe 3 O 4 spheres were utilized as a sorbent in magnetic solid phase extraction of gemfibrozil and warfarin (as the model analytes). The extracted model analytes were desorbed by a suitable organic solvent and were analyzed by high-performance liquid chromatography. Under optimized condition, the linearity of the method was in the range of 0.1-200.0 μg/L for the selected analytes in water. The limits of detection were calculated to be in the range of 0.026-0.055 μg/L for warfarin and gemfibrozil, respectively. The limits of quantification were calculated to be in the range of 0.089-0.185 μg/L. The inter-day and intra-day relative standard deviations were determined to be in the range of 1.4%-3.3% in three concentrations in order to calculate the method precision. Furthermore, the enrichment factors were found to be 78 and 81 for warfarin and gemfibrozil, respectively. Moreover, the calculated absolute recoveries were between 78% and 81%. The obtained recoveries indicated that the method was useful and applicable in complicated real samples.

Green synthesis and characterization of NiFe2O4@ZnMn2O4 magnetic nanocomposites: An efficient and reusable spinel nanocatalyst for the synthesis of tetrahydropyrimidine and polyhydroquinoline derivatives under microwave irradiation

“…These MNCs exhibit distinct physical and chemical properties arising from the synergistic interactions between the different constituent metals 11,12 . Furthermore, an additional beneficial characteristic is the ability of the nanocatalyst to be easily recovered through the utilization of an external magnet, owing to its magnetic properties 13,14 . This approach effectively decreases the operational expenses and potentially facilitates the convenient reutilization of the catalyst.…”

“…11,12 Furthermore, an additional beneficial characteristic is the ability of the nanocatalyst to be easily recovered through the utilization of an external magnet, owing to its magnetic properties. 13,14 This approach effectively decreases the operational expenses and potentially facilitates the convenient reutilization of the catalyst. The catalytic efficiency of spinel ferrites containing transition metals is greatly enhanced as a result of the fast electron exchange occurring between their tetrahedral and octahedral sites.…”

Design of experiments (DoE) to develop and to optimize extraction of psychoactive substances

“…14 With MSPE, the target analytes are conveniently separated by the assistance of a magnetic eld, without the need for additional centrifugation or ltration steps, simplifying the pretreatment process and improving the extraction efficiency. 15 MSPE is frequently used for the extraction of pollutants from wastewater, chemicals derived from synthetic organic pollutants, pesticides, therapeutic medications, and heavy metal ions [16][17][18][19][20] due to its convenience, quick extraction process, good reusability, and environmental friendliness.…”