Cranial Reossification with Absorbable Plates

Ascherman, Jeffrey A.; Knowles, Sean L.; Marin, Vince; Prisant, Nadia; Hu, Guoli; Chiu, David

doi:10.1097/00006534-200103000-00017

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…The importance of intact dura mater in the osteogenesis of cranium has been reported in numerous studies. 30 For example, the dura mater was more osteogenic than the pericranium with two layers of nonresorbable PTFE barrier membranes in a rabbit calvarial bone defect model, which was consistent with our results. 31 In some studies, the microenvironment associated with the degradation of chitosan appeared to cause an inflammatory reaction in vivo.…”

Section: Discussionsupporting

confidence: 91%

Bioelectric effect of a chitosan bioelectret membrane on bone regeneration in rabbit cranial defects

Wang

Shi

Gong

et al. 2012

Journal of Bioactive and Compatible Polymers

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In this study, the effects of a chitosan bioelectret membrane on bone regeneration in a rabbit cranial defect model were examined. The bioelectret was fabricated by film casting and polarized by grid-controlled corona charging (−1 kV). In vitro, the equivalence surface charge density of the bioelectret gradually reduced under both wet and dry conditions. In vivo, two rectangular transosseous defects of 8 mm × 10 mm were created symmetrically on each rabbit cranial bone. The defects were treated with the bioelectret membrane, with unpolarized membrane, and no membrane, respectively. The rabbits were killed at 4, 8, and 12 weeks postoperatively, and specimens were examined by micro-computed tomography and histological analysis. The bioelectret membrane recipients had a significantly higher volume of newly formed bone and greater rate of material degradation than the unpolarized membrane. Furthermore, the bioelectret membrane induced new bone formation not only around the host bone but also in the center of the defects. The chitosan bioelectret membrane application has an apparent potential in guided bone regeneration applications.

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Section: Discussionsupporting

confidence: 91%

Bioelectric effect of a chitosan bioelectret membrane on bone regeneration in rabbit cranial defects

Wang

Shi

Gong

et al. 2012

Journal of Bioactive and Compatible Polymers

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Cranial Defect Reconstruction in an Experimental Model Using Different Mixtures of Bioglass and Autologous Bone

Conejero¹,

Lee²,

Ascherman³

2007

Journal of Craniofacial Surgery

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The purpose of this study was to investigate bone healing in a rabbit cranial defect model using different mixtures of bioglass (NovaBone C/M; Porex Surgical, Inc., Newnan, GA) and autologous bone with and without an overlying absorbable plate (Lactosorb; Walter Lorenz Surgical, Jacksonville, FL). Twelve rabbits were divided into three groups, and a 2 cm diameter cranial defect was created in each rabbit. Group I defects were filled with 80% bioglass and 20% autologous bone, group II with 60% bioglass and 40% autologous bone, and group III with 60% bioglass and 40% autologous bone with the addition of an absorbable plate placed directly over the reconstructed defect to help separate it from the overlying soft tissues. Rabbits were euthanized 6 months postoperatively. Histologic examination was then performed. The size of the remaining bone gap, area of reossification within the defect, and percentage of fibrous tissue within the defect were measured. Histologic analyses revealed that group II animals had an increased cross-sectional area of bone formation and decreased bone gap when compared with group I and III animals (P < 0.05). There were no statistical differences between groups I and III with regard to bone formation. This study suggests that when combining bioactive glass and autologous bone for repairing cranial defects, a combination of 60% bioactive glass and 40% bone graft yields superior results to a combination of 80% bioactive glass and 20% bone graft. Placing an absorbable plate over a defect filled with 60% bioactive glass and 40% bone graft inhibits rather than promotes reossification.

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Reconstruction of Cranial Bone Defects Using a Quick-Setting Hydroxyapatite Cement and Absorbable Plates

Ascherman¹,

Foo²,

Nanda³

et al. 2008

Journal of Craniofacial Surgery

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We examine the 6-month histology of a quick-setting hydroxyapatite cement (Mimix), with and without absorbable plates (LactoSorb), after placement in critical size defects made in the skull of 20 New Zealand white rabbits. Two 10-mm-diameter parietal defects were made in each rabbit. One defect was placed on each side of the sagittal suture. In 10 animals, the left defect was filled with Mimix alone, and in the other 10, an absorbable plate was placed across the base of the left defect before Mimix placement. The right-sided defect served as a control in all animals, with no material placed in or across this defect. The rabbits were killed 6 months postoperatively. A bone pathologist performed histologic examinations of the specimens looking specifically for evidence of inflammatory reaction and bone formation. There was no inflammation around the dura or any other negative histologic reaction in either the study groups or the control. Growth of new bone into the Mimix was found along the periphery in all specimens. We found no migration or displacement of the Mimix from any of the calvarial defects.

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Cranial Reossification with Absorbable Plates

Cited by 4 publications

References 19 publications

Bioelectric effect of a chitosan bioelectret membrane on bone regeneration in rabbit cranial defects

Bioelectric effect of a chitosan bioelectret membrane on bone regeneration in rabbit cranial defects

Cranial Defect Reconstruction in an Experimental Model Using Different Mixtures of Bioglass and Autologous Bone

Reconstruction of Cranial Bone Defects Using a Quick-Setting Hydroxyapatite Cement and Absorbable Plates

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