Reconstruction of Cranial Bone Defects Using a Quick-Setting Hydroxyapatite Cement and Absorbable Plates

Ascherman, Jeffrey A.; Foo, Roy; Nanda, Dawne; Parisien, May

doi:10.1097/scs.0b013e31817bd83e

Cited by 23 publications

(10 citation statements)

References 17 publications

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“…Also, Hollinger and Kleinschmidt [36] confirmed that untreated 15-mm cranial defects created in New Zealand white rabbits showed less than 10% bone regeneration after 48 weeks. However, Ascherman et al [37] used 10-mm diameter defects as a CSD in their study of the 6-month histology of a quick-setting hydroxyapatite cement, with and without absorbable plates. In 2007, Pripatnanont et al [38] used a bicortical 10 × 10 mm skull defect model in their study examining the osteoconductive ability of 3 bovine hydroxyapatites.…”

Section: Discussionmentioning

confidence: 99%

Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects

Lee

Rhyu

et al. 2010

J Periodontal Implant Sci

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PurposeFibronectin (FN) has been shown to stimulate bone regeneration in animal models. The aim of this study was to evaluate the capacity of bovine bone mineral coated with synthetic oligopeptides to enhance bone regeneration in rabbit calvarial defects.MethodsOligopeptides including fibrin-binding sequences of FN repeats were synthesized on the basis of primary and tertiary human plasma FN structures. Peptide coated and uncoated bone minerals were implanted into 10 mm calvarial defects in New Zealand white rabbits, and the animals were sacrificed at 4 or 8 weeks after surgery. After specimens were prepared, histologic examination and histomorphometric analysis were performed.ResultsAt 4 weeks after surgery, the uncoated groups showed a limited amount of osteoid formation at the periphery of the defect and the oligopeptide coated groups showed more osteoid formation and new bone formation in the center of the defect as well as at the periphery. At 8 weeks, both sites showed increased new bone formation. However, the difference between the two sites had reduced.ConclusionsFibrin-binding synthetic oligopeptide derived from FN on deproteinized bovine bone enhanced new bone formation in rabbit calvarial defects at the early healing stage. This result suggests that these oligopeptides can be beneficial in reconstructing oral and maxillofacial deformities or in regenerating osseous bone defects.

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Section: Discussionmentioning

confidence: 99%

Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects

Lee

Rhyu

et al. 2010

J Periodontal Implant Sci

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“…2,4,52,56 There has been evidence of integration of new bone into the HAC at the periphery of the lesion with no foreign body reaction or inflammatory response, even in animal models. In a series of 54 patients with HAC, Arriaga and Chen 2 reported a reduction in CSF leak from 12.5% to 3.7% when compared with a similar-sized cohort in which only autologous fat was used.…”

Section: Discussionmentioning

confidence: 99%

“…The main advantage of alloplastic materials in general is the lack of potential added donor-site morbidity. 4,31 Any urgent reentry to the mastoid cavity or the posterior fossa can be easily performed with the closure technique demonstrated in our case series. As of the close of our study, none of the patients had required reoperations for tumor regrowth or wound-related problems.…”

Section: Resorbable Plate Cranioplasty-an Option?mentioning

confidence: 99%

Prevention of postoperative cerebrospinal fluid leaks with multilayered reconstruction using titanium mesh–hydroxyapatite cement cranioplasty after translabyrinthine resection of acoustic neuroma

Manjila¹,

Weidenbecher

Semaan

et al. 2013

JNS

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PostoPerative CSF leak after translabyrinthine surgery for removal of an acoustic neuroma (TLAN) is recognized as an infrequent complication, despite the best prophylactic techniques currently available. [29][30][31][32][33]36,40,44 To prevent postoperative CSF leaks after TLAN, several surgical methods have been tried, using different autografts and allografts, alone or in combinations, with varying success rates. 6,8,10,11,13,[22][23][24]27,28,42,46 These range from calvarial bone autografts, bone cements, metals, and resins to resorbable bone plates. 5,6,51 Calvarial grafts can be time consuming and less malleaPrevention of postoperative cerebrospinal fluid leaks with multilayered reconstruction using titanium mesh-hydroxyapatite cement cranioplasty after translabyrinthine resection of acoustic neuroma Object. Several prophylactic surgical methods have been tried to prevent CSF leakage after translabyrinthine resection of acoustic neuroma (TLAN). The authors report an improvised technique for multilayer watertight closure using titanium mesh-hydroxyapatite cement (HAC) cranioplasty in addition to dural substitute and abdominal fat graft after TLAN.Methods. The study was limited to 42 patients who underwent TLAN at University Hospitals Case Medical Center using this new technique from 2006 to 2012. Systematic closure of the surgical wound in layers using temporalis fascia, dural substitute, dural sealant, adipose graft, titanium mesh, and then HAC was performed in each case. Temporalis muscle and eustachian tube obliteration were not used. The main variables studied were patient age, tumor size, tumor location, cosmetic outcome, length of hospitalization, and the incidence of CSF leak, pseudomeningocele, and infection.Results. Excellent cosmetic outcome was achieved in all patients. There were no cases of postoperative CSF rhinorrhea, incisional CSF leak, or meningitis. Cosmetic results were comparable to those achieved using HAC alone. This cost-effective technique used only a third of the HAC required for traditional closure in which the entire mastoid defect is filled with cement, predisposing to infection. Postoperative CT and MRI showed excellent bony contouring and dural reconstitution, respectively.Conclusions. The authors report on successful use of titanium mesh-HAC cranioplasty in preventing postoperative CSF leak after TLAN in all cases in their series. The titanium mesh provides a well-defined anatomical dissection plane that would make reoperation easier than working through scarred soft tissue. The mesh bolsters the fat graft and keeps HAC out of direct contact with mastoid air cells, thereby reducing the risk of infection. The cement cranioplasty does not preclude subsequent implantation of a bone-anchored hearing aid.

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“…Hydroxyapatite, an artificial material with osteoinductivity [14], is used in various operations to fill bone defects [15][16][17][18][19][20][21]. Using this artificial material makes the treatment to reconstruct the distal phalanx for Allen's type 3 and type 4 injuries less invasive.…”

Section: Introductionmentioning

confidence: 99%

Combined usage of hydroxyapatite and cross-finger flap for fingertip reconstruction

Nagasao

Kurihara

Shimizu

et al. 2014

Journal of Plastic Surgery and Hand Surgery

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Reconstruction for fingertip defects categorized as Type 3 and Type 4 in Allen's classification is challenging, because surgeons need to reconstruct not only the pulp but also great parts of the distal phalangeal bone. This paper introduces an original technique for the reconstruction of defects of these types. The defects of seven fingers (two small fingers and five index fingers) of seven patients (three males and four females; aged 14-44 years) were repaired. After the fingertip is divided in a fish-mouth fashion to expose the stump of the distal phalangeal bone, a curved block of hydroxyapatite is grafted to fill the phalangeal defect and straighten the nail bed. A rectangular flap is raised from the dorsal side of the neighbouring finger in the region between the PIP and DIP joints. Then the fish-mouth region carrying the grafted hydroxyapatite is covered with the rectangular flap to reconstruct the pulp. The rectangular cross-finger flap is separated 3-4 weeks postoperatively. In all seven cases, the flap survived completely. Infection developed in no case. In all cases, aesthetic appearance of the pulp and nail presented improvement, satisfying the patients. Combined usage of hydroxyapatite and a cross-finger flap from the neighbouring finger is an effective method for the reconstruction of type 3 and type 4 defects in Allen's classification.

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Reconstruction of Cranial Bone Defects Using a Quick-Setting Hydroxyapatite Cement and Absorbable Plates

Cited by 23 publications

References 17 publications

Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects

Effects of fibrin-binding oligopeptide on osteopromotion in rabbit calvarial defects

Prevention of postoperative cerebrospinal fluid leaks with multilayered reconstruction using titanium mesh–hydroxyapatite cement cranioplasty after translabyrinthine resection of acoustic neuroma

Combined usage of hydroxyapatite and cross-finger flap for fingertip reconstruction

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