Cranial electrotherapy stimulation and transcranial pulsed current stimulation: A computer based high-resolution modeling study

Datta, Abhishek; Dmochowski, Jacek; Guleyupoglu, Berkan; Bikson, Marom; Fregni, Felipe

doi:10.1016/j.neuroimage.2012.09.062

Cited by 96 publications

(82 citation statements)

References 44 publications

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“…A computer-based high-resolution modeling of the brain had predicted the possible existence of such a connection (Datta et al, 2013), which is confirmed for the first time by our in vivo study. While the thalamus was not activated using our simple finger tapping motor paradigm, the thalamus does play a large role in coordinating ascending sensory and motor inputs with descending cognitive control systems.…”

Section: Discussionsupporting

confidence: 84%

“…The flashing lights may be a unique response to the specific pulse properties of the device as described in the method section. The modeling of the responses to pulsed current stimulators of different pulse properties imply that simple monophasic, symmetric, or asymmetric biphasic pulses may not cause a flashing lights phenomenon (Datta et al, 2013). Indeed unpublished data and clinical experience of our team confirm the dependence of the flashing light phenomenon on tPCS pulse properties and does not occur during tDCS (Alon et al, 1998(Alon et al, , 2011(Alon et al, , 2012.…”

Section: Discussionmentioning

confidence: 53%

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Modulation of Resting State Functional Connectivity of the Motor Network by Transcranial Pulsed Current Stimulation

et al. 2014

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The effects of transcranial pulsed current stimulation (tPCS) on resting state functional connectivity (rs-FC) within the motor network were investigated. Eleven healthy participants received one magnetic resonance imaging (MRI) session with three resting state functional MRI (rs-fMRI) scans, one before stimulation (PRE-STIM) to collect baseline measures, one during stimulation (STIM), and one after 13 min of stimulation (POST-STIM). Rs-FC measures during the STIM and POST-STIM conditions were compared to the PRE-STIM baseline. Regions of interest for the rs-FC analysis were extracted from the significantly activated clusters obtained during a finger tapping motor paradigm and included the right primary motor cortex (R M1), left primary motor cortex (L M1), supplemental motor area (SMA), and cerebellum (Cer). The main findings were reduced rs-FC between the left M1 and surrounding motor cortex, and increased rs-FC between the left M1 and left thalamus during stimulation, but increased rs-FC between the Cer and right insula after stimulations. Bivariate measures of connectivity demonstrate reduced strength of connectivity for the whole network average (p=0.044) and reduced diversity of connectivity for the network average during stimulation (p=0.024). During the POST-STIM condition, the trend of reduced diversity for the network average was statistically weaker (p=0.071). In conclusion, while many of the findings are comparable to previous reports using simultaneous transcranial direct current stimulation (tDCS) and fMRI acquisition, we also demonstrate additional changes in connectivity patterns that are induced by tPCS.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 53%

Modulation of Resting State Functional Connectivity of the Motor Network by Transcranial Pulsed Current Stimulation

et al. 2014

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“…Anodal tDCS over the prefrontal cortex may possibly increase neural signal and noise (Antal et al, 2004;Dockery et al, 2009;Miniussi et al, 2013) during the encoding of verbal and non-verbal stimuli, resulting in weaker recognition in the delayed recognition task. Furthermore, normal variations in inter-individual anatomy and electrode montages determine the current flow distribution and may account for the fact that different electrode montages may lead to different patterns of current flow across the brain Datta et al, 2013;Truong et al, 2013;Parazzini et al, 2015;Labruna et al, 2016).…”

Section: Verbalmentioning

confidence: 99%

Effect of prefrontal and parietal tDCS on learning and recognition of verbal and non-verbal material

Manuel

Schnider

2016

Clinical Neurophysiology

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h i g h l i g h t stDCS over left or right PFC or PPC affects differentially encoding of verbal and non-verbal material. tDCS over PPC enhanced recognition of non-verbal items; tDCS over left PFC decreased recognition for both materials. Functional hemispheric lateralization does not follow the same rules throughout the brain. a b s t r a c tObjective: Information learned in a spaced way is usually better recognized than information learned in a massed way. The brain mechanisms underlying this spacing effect remain unclear. Methods: We applied anodal transcranial direct current stimulation (tDCS) to the left and right prefrontal (PFC) or posterior parietal (PPC) cortices to study how stimulation influences learning and retrieval of information, as evidenced by item recognition and the spacing effect, and whether the effects are lateralized according to stimulus material and site of stimulation. We devised a continuous recognition task with verbal and non-verbal stimuli repeated either immediately or after a delay. Stimulus recognition was tested 30 min later. Results: There was a spacing effect for both materials, which, however, was not modulated by tDCS. Nonetheless, tDCS differentially impacted memory retrieval regardless of repetition mode during learning: tDCS over the PPC during learning enhanced recognition of non-verbal material regardless of side of stimulation, while tDCS over the left PFC decreased recognition regardless of material. Conclusions: The PPC seems to be involved specifically in the mnesic treatment of non-verbal material whereas the left PFC specifically influences learning irrespective of stimulus material. Significance: Prefrontal and posterior parietal cortices follow different lateralization rules in recognition memory.

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“…При НБ наблю-дается снижение уровня сывороточного серотони-на, коррелирующее с выраженностью болевого син-дрома и сопутствующей депрессии [28]. В одном из сравнительных исследований, посвященных изуче-нию лечения депрессии антидепрессантами и анти-депрессантами в комбинации с курсом ТКМС, была показана более высокая эффективность комбини-рованной терапии [29,30].…”

Section: воздействие магнитным полем: -транскраниальная магнитная стиunclassified

The neurophysiological basis of the effectiveness of transcranial methods for the treatment of neuropathic pain

Razumov¹,

Ea²

2015

Vopr. kurortol. fizioter. lech. fiz. kul't.

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Хронический болевой синдром является рас-пространенной причиной дезадаптации и снижения качества жизни пациентов, вызывая необходимость в частых визитах к врачу, повторных курсах стацио-нарного или амбулаторного лечения, постоянном приеме обезболивающих препаратов. По данным Российского исследования EPIC, жалобы на боль являются причиной обращения к неврологу в 39% случаев [1].Выделяют острую (ноцицептивную) и хрониче-скую (невропатическую) боль, которые различают-ся по этиопатогенезу и условиям возникновения. Ноцицептивная боль возникает при нарушении це-лостности тканей в ответ на травматическое по-вреждение или воспаление. В этих случаях боль мо-жет продолжаться весь период заживления, форми-рования рубца или восстановления тканей. Сведения об авторах:Разумов Александр Николаевич -академик РАН, д.м.н., проф., ди-ректор МНПЦ МРВСМ, e-mail: a-razumov@mail.ru; Мельникова Екатерина Александровна -к.м.н., рук. отд. реабилитации боль-ных с заболеваниями нервной системы МНПЦ МРВСМ, e-mail: melkaterina3@yandex.ru В статье приведены данные о распространенности хронических болевых синдромов в клинической практике. Показана актуальность проблемы поиска эффективных методов лечения таких больных. Проанализированы механизмы развития невропатической боли. Приведены возможные патогенетически обоснованные пути фармакологической и немедикамен-тозной коррекции хронической боли. Освещены результаты последних метаанализов сравнительной эффективности транскраниальных методов. Обозначены направления дальнейших исследований в области монотерапии и комбинирован-ного лечения невропатической боли. Ключевые слова: невропатическая боль, транскраниальная электростимуляция, транскраниальная магнитная стимуляция.The present article reports the data concerning the prevalence of chronic pain syndromes in clinical practice. The importance of addressing the problem of finding effective treatment modalities for the patients presenting with these conditions is emphasized. The mechanisms of neuropathic pain are analyzed. The possible pathogenetically sound substantiations for the pharmacological and non-pharmacological treatment of chronic pain are discussed. The article highlights the results of recent meta-analyses of the comparative effectiveness of transcranial methods. The mail lines of further investigations in the field of monotherapy and combined treatment of neuropathic pain are outlined.

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Cranial electrotherapy stimulation and transcranial pulsed current stimulation: A computer based high-resolution modeling study

Cited by 96 publications

References 44 publications

Modulation of Resting State Functional Connectivity of the Motor Network by Transcranial Pulsed Current Stimulation

Modulation of Resting State Functional Connectivity of the Motor Network by Transcranial Pulsed Current Stimulation

Effect of prefrontal and parietal tDCS on learning and recognition of verbal and non-verbal material

The neurophysiological basis of the effectiveness of transcranial methods for the treatment of neuropathic pain

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