CPT loaded nanoparticles based on beta-cyclodextrin-grafted poly(ethylene glycol)/poly (l-glutamic acid) diblock copolymer and their inclusion complexes with CPT

Du, Fu‐Sheng; Meng, Haijing; Xu, Ke; Xu, Yanyun; Luo, Peng; Luo, Yu; Lü, Wei; Huang, Jin; Liu, Shiyuan; Yu, Jiahui

doi:10.1016/j.colsurfb.2013.09.015

Cited by 40 publications

(19 citation statements)

References 30 publications

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“…Camptothecin (CPT), a hydrophobic anticancer drug, has limited curative effect on account of slight solubility in aqueous environment, which results in intensive research on CPT modifications to improve its solubility in aqueous solution [8,13,23]. Among these modifications, the addition of solubilizers like CDs and their derivatives is an effective and efficient method [13,23]. So it is inferred that Ac--CD, a CD derivative, was also a kind of ideal carrier material.…”

Section: Introductionmentioning

confidence: 99%

A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery

2016

Journal of Nanomaterials

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According to previous reports, low pH-triggered nanoparticles were considered to be excellent carriers for anticancer drug delivery, for the reason that they could trigger encapsulated drug release at mild acid environment of tumor. Herein, an acid-sensitiveβ-cyclodextrin derivative, namely, acetalated-β-cyclodextrin (Ac-β-CD), was synthesized by acetonation and fabricated to nanoparticles through single oil-in-water (o/w) emulsion technique. At the same time, camptothecin (CPT), a hydrophobic anticancer drug, was encapsulated into Ac-β-CD nanoparticles in the process of nanoparticle fabrication. Formed nanoparticles exhibited nearly spherical structure with diameter of209±40 nm. The drug release behavior of nanoparticles displayed pH dependent changes due to hydrolysis of Ac-β-CD. In order to overcome the disadvantages of nanoparticle and broaden its application, injectable hydrogels with Ac-β-CD nanoparticles were designed and prepared by simple mixture of nanoparticles solution and graphene oxide (GO) solution in this work. The injectable property was confirmed by short gelation time and good mobility of two precursors. Hydrogels were characterized by dynamic mechanical test and SEM, which also reflected some structural features. Moreover, all hydrogels underwent a reversible sol-gel transition in alkaline environment. Finally, the results ofin vitrodrug release profile indicated that hydrogel could control drug release or bind drug inside depending on the pH value of released medium.

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Section: Introductionmentioning

confidence: 99%

A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery

2016

Journal of Nanomaterials

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“…Additionally, cyclodextrins inhibit the p-gp, responsible for drug efflux and cytochrome P450, responsible for drug metabolism that assists in enhanced oral bioavailability. Among cyclodextrin derivatives, HPbCD has the highest drug solubilizing capability along with least toxicity (Dua et al, 2014;Madan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

et al. 2017

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Fisetin (FST), a potent anticancer phytoconstituent, exhibits poor aqueous solubility and hence poor bioavailability. The aim of the present study is to improve the oral bioavailability of FST by encapsulating into PLGA NPs (poly-lactide-co-glycolic acid nanoparticles) as a complex of HPbCD (hydroxyl propyl beta cyclodextrin) and to assess its anti-cancer activity against breast cancer cells. FST-HPbCD inclusion complex (FHIC) was prepared and the supramolecular complex formation was characterized by FTIR, DSC, PXRD and 1 H NMR. FHIC encapsulated PLGA nanoparticles (FHIC-PNP) were prepared and were studied for in vitro anticancer activity, cellular uptake, apoptosis and reactive oxygen species generation in MCF-7 human breast cancer cells. Comparative bioavailability of FST was determined after oral administration in C57BL6 mice as pure FST and FHIC-PNP. The results revealed that FHIC-PNP not only enhanced the anti-cancer activity and apoptosis of FST against MCF-7 cells but also improved its oral bioavailability, as demonstrated by increased peak plasma concentration and total drug absorbed.

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“…1,2 Traditional antitumor drugs, such as doxorubicin (DOX), camptothecin (CPT), and paclitaxel (PTX), show high cytotoxicity for various tumor cells, but their clinical use is limited by many fatal drawbacks, such as poor solubility in water, uncontrolled release behavior, acquired multidrug resistance, and severe side effects. [3][4][5] To overcome these obstacles, various drug delivery systems (DDSs) have been designed and developed to efficiently deliver anticancer drugs to tumor sites and reduce accumulation in normal sites. For instance, nanoparticles, liquid emulsions, films, and liposomes have been prepared…”

Section: Introductionmentioning

confidence: 99%

pH-sensitive micelles self-assembled from polymer brush (PAE-g-cholesterol)-b-PEG-b-(PAE-g-cholesterol) for anticancer drug delivery and controlled release

Huang¹,

Liao²,

Zhang³

et al. 2017

IJN

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CPT loaded nanoparticles based on beta-cyclodextrin-grafted poly(ethylene glycol)/poly (l-glutamic acid) diblock copolymer and their inclusion complexes with CPT

Cited by 40 publications

References 30 publications

A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery

A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery

Enhanced oral bioavailability and anticancer efficacy of fisetin by encapsulating as inclusion complex with HPβCD in polymeric nanoparticles

pH-sensitive micelles self-assembled from polymer brush (PAE-<em>g</em>-cholesterol)-<em>b</em>-PEG-<em>b</em>-(PAE-<em>g</em>-cholesterol) for anticancer drug delivery and controlled release

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