pH-sensitive micelles self-assembled from polymer brush (PAE-&lt;em&gt;g&lt;/em&gt;-cholesterol)-&lt;em&gt;b&lt;/em&gt;-PEG-&lt;em&gt;b&lt;/em&gt;-(PAE-&lt;em&gt;g&lt;/em&gt;-cholesterol) for anticancer drug delivery and controlled release

Huang, Xiangxuan; Liao, Wenbo; Zhang, Gang; Kang, Shimin; Zhang, Can Yang

doi:10.2147/ijn.s130037

Cited by 49 publications

(29 citation statements)

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“…For example, the poor oxygen perfusion in most kinds of tumor cells causes the elevated levels of lactic acid, resulting in weakly acidic extracellular and intracellular tumor microenvironments (Wojtkowiak et al, 2011). Lots of researchers have reported that the weakly acidic microenvironment could be used as the specific cue for anticancer drug delivery and controlled release (Huang et al, 2017;Niu et al, 2018;Farjadian et al, 2019;Limeres et al, 2019). For instance, Zhang et al reported a pH-sensitive PM which was self-assembled from poly(ethylene glycol) methyl ether-b-peptide-g-cholesterol (mPEG-b-P-g-Chol) for DOX delivery and controlled release.…”

Section: Introductionmentioning

confidence: 99%

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

et al. 2020

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In this work, a pH-sensitive liposome-polymer nanoparticle (NP) composed of lipid, hyaluronic acid (HA) and poly(b-amino ester) (PBAE) was prepared using layer-by-layer (LbL) method for doxorubicin (DOX) targeted delivery and controlled release to enhance the cancer treatment efficacy. The NP with pH-sensitivity and targeting effect was successfully prepared by validation of charge reversal and increase of hydrodynamic diameter after each deposition of functional layer. We further showed the DOX-loaded NP had higher drug loading capacity, suitable particle size, spherical morphology, good uniformity, and high serum stability for drug delivery. We confirmed that the drug release profile was triggered by low pH with sustained release manner in vitro. Confocal microscopy research demonstrated that the NP was able to effectively target and deliver DOX into human non-small cell lung carcinoma (A549) cells in comparison to free DOX. Moreover, the blank NP showed negligible cytotoxicity, and the DOX-loaded NP could efficiently induce the apoptosis of A549 cells as well as free DOX. Notably, in vivo experiment results showed that the DOX-loaded NPs effectively inhibited the growth of tumor, enhanced the survival of tumor-bearing mice and improved the therapeutic efficacy with reduced side-effect comparing with free drug. Therefore, the NP could be a potential intelligent anticancer drug delivery carrier for cancer chemotherapy, and the LbL method might be a useful strategy to prepare multi-functional platform for drug delivery.

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Section: Introductionmentioning

confidence: 99%

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

et al. 2020

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“…Abbreviations: PEG-poly(ethylene glycol), PAE-poly(β-amino esters) g-cholesterol, and DOX-doxorubicin. Adapted and modified with permission from [92].…”

Section: Challenges With Targeted Delivery Challengesmentioning

confidence: 99%

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Chivere

Kondiah

Choonara

et al. 2020

Cancers

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Routes of drug administration and their corresponding physiochemical characteristics play major roles in drug therapeutic efficiency and biological effects. Each route of delivery has favourable aspects and limitations. The oral route of delivery is the most convenient, widely accepted and safe route. However, the oral route of chemotherapeutics to date have displayed high gastric degradation, low aqueous solubility, poor formulation stability and minimum intestinal absorption. Thus, mainstream anti-cancer drugs in current formulations are not suitable as oral chemotherapeutic formulations. The use of biopolymers such as chitosan, gelatin, hyaluronic acid and polyglutamic acid, for the synthesis of oral delivery platforms, have potential to help overcome problems associated with oral delivery of chemotherapeutics. Biopolymers have favourable stimuli-responsive properties, and thus can be used to improve oral bioavailability of anti-cancer drugs. These biopolymeric formulations can protect gastric-sensitive drugs from pH degradation, target specific binding sites for targeted absorption and consequently control drug release. In this review, the use of various biopolymers as oral drug delivery systems for chemotherapeutics will be discussed.

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“…Multi-functional drug delivery systems (MDDSs) with targeting and stimulus-sensitive attributes, as an active research area, [1][2][3][4][5][6][7][8][9] can target the site of cancer cells to enhance the intracellular delivery of a drug and respond to local stimuli that are characteristic of the pathological site by shedding a protective coating and releasing entrapped drug to minimize undesired side-effect in normal cells in chemotherapy. [10][11][12] Meanwhile, degradable polymer coatings have been widely used in drug delivery systems due to their excellent drug blocking capacity and biodegradability, 13 where degradable polymers are often combined with targeting units to achieve targeted MDDS with stimuli-responsive functions which are responsive to the microenvironment of cancer cells (temperature, 14,15 pH, [16][17][18][19] glutathione (GSH) concentration, [20][21][22] or light [23][24][25] ). In addition, MDDS with enhanced cytotoxicity to cancer has been recognized as a new approach in developing a synergistic MDDS.…”

Section: Introductionmentioning

confidence: 99%

Dual-responsive dithio-polydopamine coated porous CeO<sub>2</sub> nanorods for targeted and synergistic drug delivery

Zhang

Hou

et al. 2018

IJN

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ObjectiveThe aim was to produce the first report of assembling degradable stimuli-responsive dithio-polydopamine coating with a cancer target unit for synergistic and targeted drug delivery.MethodsA multifunctional drug delivery system was constructed by coating a dual-responsive dithio-polydopamine (PDS) on porous CeO2 nanorods and subsequent conjugation of lactose derivative, where the PDS was formed by self-polymerization of dithio-dopamine (DOPASS).ResultsThe multifunctional drug delivery system displayed excellent cancer targeted ability resulting from the conjugation of lactose derivative, which could specifically recognize the overexpressed asialoglycoprotein receptors on the surface of HepG2 cells. It also showed a dual-responsive property of glutathione and pH, achieving controllable drug release from the cleavage of disulfide bond and subsequent degradation of PDS in cancer cells. Moreover, the degradation of PDS led to the exposure of CeO2 nanorods, which has a synergistic anticancer effect due to its cytotoxicity to cancer cells.ConclusionThis work presents a good example of a rational design towards synergistic and targeted DDS for cancer chemotherapies.

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pH-sensitive micelles self-assembled from polymer brush (PAE-<em>g</em>-cholesterol)-<em>b</em>-PEG-<em>b</em>-(PAE-<em>g</em>-cholesterol) for anticancer drug delivery and controlled release

Cited by 49 publications

References 50 publications

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment

Dual-responsive dithio-polydopamine coated porous CeO<sub>2</sub> nanorods for targeted and synergistic drug delivery

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