A pH-Sensitive Injectable Nanoparticle Composite Hydrogel for Anticancer Drug Delivery

Abstract

According to previous reports, low pH-triggered nanoparticles were considered to be excellent carriers for anticancer drug delivery, for the reason that they could trigger encapsulated drug release at mild acid environment of tumor. Herein, an acid-sensitiveβ-cyclodextrin derivative, namely, acetalated-β-cyclodextrin (Ac-β-CD), was synthesized by acetonation and fabricated to nanoparticles through single oil-in-water (o/w) emulsion technique. At the same time, camptothecin (CPT), a hydrophobic anticancer drug, was encapsulated into Ac-β-CD nanoparticles in the process of nanoparticle fabrication. Formed nanoparticles exhibited nearly spherical structure with diameter of209±40 nm. The drug release behavior of nanoparticles displayed pH dependent changes due to hydrolysis of Ac-β-CD. In order to overcome the disadvantages of nanoparticle and broaden its application, injectable hydrogels with Ac-β-CD nanoparticles were designed and prepared by simple mixture of nanoparticles solution and graphene oxide (GO) solution in this work. The injectable property was confirmed by short gelation time and good mobility of two precursors. Hydrogels were characterized by dynamic mechanical test and SEM, which also reflected some structural features. Moreover, all hydrogels underwent a reversible sol-gel transition in alkaline environment. Finally, the results ofin vitrodrug release profile indicated that hydrogel could control drug release or bind drug inside depending on the pH value of released medium.

Characterization and in vitro release kinetics of antimalarials from whey protein-based hydrogel biocomposites

“…In vitro cumulative drug release of CQ and PG from hydrogels revealed that the hydrogels had the capacity to retain a substantial amount of drug in simulated gastric juice condition. Similar findings were reported by some researchers [35,36]. The solubility of the drugs influenced their release rate from the hydrogels; Castro et al [19] and Alhnan et al reported similar findings [37].…”

Preparation of Fe3O4/Reduced Graphene Oxide Nanocomposites with Good Dispersibility for Delivery of Paclitaxel

“…Moreover, graphene is used as nanoscale building blocks for new nanocomposites because of its unique properties [12][13][14]. Recent research showed that magnetic nanoparticles (MNPs) could be attached to graphene, which can be applied in magnetic resonance imaging [15], targeted drug delivery [16,17], biocompatible adsorbent [18], magnetic solid phase extraction [19], microwave electromagnetic [20], Schottky diode applications [21], and biomolecule immobilization [22].…”

Novel Nanomaterials Enable Biomimetic Models of the Tumor Microenvironment

“…A hydrogel with a DNA backbone permitted tethering of DNA-functionalized AuNP via complementary base pair binding; upon irradiation at the AuNP SPR, the DNA cross-link melts releasing the AuNP and any encapsulated drug [48]. Additional composite hydrogels have been similarly created to be sensitive to pH, which is particularly important within the tumor microenvironment [49].…”