CPSF4 promotes tumor-initiating phenotype by enhancing VEGF/NRP2/TAZ signaling in lung cancer

Song, YingQiu; Sun, Kai; Gong, LiLan; Shi, Linli; Qin, Tao; Wang, ShuSen; Deng, Wuguo; Chen, Wangbing; Zheng, Fei-Meng; Li, Guiling

doi:10.1007/s12032-022-01919-1

Cited by 2 publications

(1 citation statement)

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“…Further analysis revealed that NEAT1 sponges miR-150 and results in the upregulation of CPSF4, a direct target of miR-150. CPSF4 is a protein involved in the processing of mRNA precursors during mRNA biogenesis [ 94 ]. Overexpression of CPSF4 trigger cell proliferation and inhibit apoptosis with distinct mechanism in several cancer [ 95 – 97 ].…”

Section: Mir-150 and Cancer Cell Proliferation And Apoptosismentioning

confidence: 99%

Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms

Ameri,

Ahmed,

Pecho

et al. 2023

Cancer Cell Int

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There is a growing interest to understand the role and mechanism of action of microRNAs (miRNAs) in cancer. The miRNAs are defined as short non-coding RNAs (18-22nt) that regulate fundamental cellular processes through mRNA targeting in multicellular organisms. The miR-150 is one of the miRNAs that have a crucial role during tumor cell progression and metastasis. Based on accumulated evidence, miR-150 acts as a double-edged sword in malignant cells, leading to either tumor-suppressive or oncogenic function. An overview of miR-150 function and interactions with regulatory and signaling pathways helps to elucidate these inconsistent effects in metastatic cells. Aberrant levels of miR-150 are detectable in metastatic cells that are closely related to cancer cell migration, invasion, and angiogenesis. The ability of miR-150 in regulating of epithelial-mesenchymal transition (EMT) process, a critical stage in tumor cell migration and metastasis, has been highlighted. Depending on the cancer cells type and gene expression profile, levels of miR-150 and potential target genes in the fundamental cellular process can be different. Interaction between miR-150 and other non-coding RNAs, such as long non-coding RNAs and circular RNAs, can have a profound effect on the behavior of metastatic cells. MiR-150 plays a significant role in cancer metastasis and may be a potential therapeutic target for preventing or treating metastatic cancer.

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Section: Mir-150 and Cancer Cell Proliferation And Apoptosismentioning

confidence: 99%