Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms

Ameri, Ali; Ahmed, Hani Moslem; Pecho, Renzon Daniel Cosme; Arabnozari, Hesamoddin; Sarabadani, Hoda; Esbati, Romina; Mirabdali, Seyedsaber; Yazdani, Omid

doi:10.1186/s12935-023-03105-3

Cited by 10 publications

(2 citation statements)

References 117 publications

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“…1 ). As mentioned previously, endothelial cells are essential components involved in vascular formation and tumor metastasis [ 66 ]. Fibroblasts in TME have a high proliferation rate, ECM production, and secretion of carcinogenesis-enhancing cytokines [ 67 ].…”

Section: Advanced Modeling and Drug Screening Systemsmentioning

confidence: 99%

The progressive trend of modeling and drug screening systems of breast cancer bone metastasis

Kolahi Azar,

Gharibshahian,

Rostami

et al. 2024

J Biol Eng

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Bone metastasis is considered as a considerable challenge for breast cancer patients. Various in vitro and in vivo models have been developed to examine this occurrence. In vitro models are employed to simulate the intricate tumor microenvironment, investigate the interplay between cells and their adjacent microenvironment, and evaluate the effectiveness of therapeutic interventions for tumors. The endeavor to replicate the latency period of bone metastasis in animal models has presented a challenge, primarily due to the necessity of primary tumor removal and the presence of multiple potential metastatic sites.The utilization of novel bone metastasis models, including three-dimensional (3D) models, has been proposed as a promising approach to overcome the constraints associated with conventional 2D and animal models. However, existing 3D models are limited by various factors, such as irregular cellular proliferation, autofluorescence, and changes in genetic and epigenetic expression. The imperative for the advancement of future applications of 3D models lies in their standardization and automation. The utilization of artificial intelligence exhibits the capability to predict cellular behavior through the examination of substrate materials' chemical composition, geometry, and mechanical performance. The implementation of these algorithms possesses the capability to predict the progression and proliferation of cancer. This paper reviewed the mechanisms of bone metastasis following primary breast cancer. Current models of breast cancer bone metastasis, along with their challenges, as well as the future perspectives of using these models for translational drug development, were discussed.

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Section: Advanced Modeling and Drug Screening Systemsmentioning

confidence: 99%

The progressive trend of modeling and drug screening systems of breast cancer bone metastasis

Kolahi Azar,

Gharibshahian,

Rostami

et al. 2024

J Biol Eng

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“…The early and accurate diagnosis of sepsis is crucial for initiating timely and targeted interventions to improve patient outcomes [ 1 , 2 ]. In recent years, there has been growing interest in the use of microRNAs (miRNAs) as biomarkers for sepsis due to their stability in blood and their involvement in immune and inflammatory responses.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA as Sepsis Biomarkers: A Comprehensive Review

Bindayna

2024

IJMS

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Sepsis, a life-threatening condition caused by the body’s dysregulated response to infection, presents a significant challenge in clinical management. Timely and accurate diagnosis is paramount for initiating appropriate interventions and improving patient outcomes. In recent years, there has been growing interest in identifying biomarkers that can aid in the early detection and prognostication of sepsis. MicroRNAs (miRNAs) have emerged as potential biomarkers for sepsis due to their involvement in the regulation of gene expression and their stability in various biological fluids, including blood. MiRNAs are small non-coding RNA molecules that play crucial roles in post-transcriptional gene regulation by binding to target messenger RNAs (mRNAs), leading to mRNA degradation or translational repression. The diagnostic and prognostic potential of miRNAs in sepsis stems from their ability to serve as sensitive and specific biomarkers reflective of the underlying pathophysiological processes. Compared to traditional biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT), miRNAs offer several advantages, including their early and sustained elevation during sepsis, as well as their stability in stored samples, making them attractive candidates for clinical use. However, despite their promise, the clinical translation of miRNAs as sepsis biomarkers faces several challenges. These include the need for standardized sample collection and processing methods, the identification of optimal miRNA panels or signatures for differentiating sepsis from other inflammatory conditions, and the validation of findings across diverse patient populations and clinical settings. In conclusion, miRNAs hold great promise as diagnostic and prognostic biomarkers for sepsis, offering insights into the underlying molecular mechanisms and potential therapeutic targets. However, further research is needed to overcome existing challenges and realize the full clinical utility of miRNAs in improving sepsis outcomes.

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The Synergetic Effect of 3D Printing and Electrospinning Techniques in the Fabrication of Bone Scaffolds

Qi,

Lv,

Huang

et al. 2024

Ann Biomed Eng

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Diverse activity of miR-150 in Tumor development: shedding light on the potential mechanisms

Cited by 10 publications

References 117 publications

The progressive trend of modeling and drug screening systems of breast cancer bone metastasis

The progressive trend of modeling and drug screening systems of breast cancer bone metastasis

MicroRNA as Sepsis Biomarkers: A Comprehensive Review

The Synergetic Effect of 3D Printing and Electrospinning Techniques in the Fabrication of Bone Scaffolds

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