COVID-19 paraclinical diagnostic tools: Updates and future trends

Abstract

Motivation: COVID-19 is one of the most widely affecting pandemics. As for many respiratory virusescaused diseases, diagnosis of COVID-19 relies on two main compartments: clinical and paraclinical diagnostic criteria. Rapid and accurate diagnosis is vital in such a pandemic. On one side, rapidity may enhance management effectiveness, while on the other, coupling efficiency and less costly procedures may permit more effective community-scale management. Methodology and main structure: In this review, we shed light on the most used and the most validated diagnostic tools. Furthermore, we intend to include few under-development techniques that may be potentially useful in this context. The practical intent of our work is to provide clinicians with a realistic summarized review of the essential elements in the applied paraclinical diagnosis of COVID-19.

Does Ibrutinib impact outcomes of viral infection by SARS-CoV-2 in mantle cell lymphoma patients?

“…While severe manifestations of COVID-19 may be the result of over released cytokines and chemoattractants such as IL-2, IL-6, IL-7, IL-10, G-CSF, IP-10/CXCL-10, MCP-1/CCL2, MIP-1a/CCL3, and TNF-alpha, (blood) interferon (INF)-γ concentration usually increases during viral infections [ 10 , 11 ].…”

“…The delay between the first symptom and the PCR test was more than 11 days, the estimated median time needed for a positive-to-negative PCR test result conversion of upper respiratory tract samples [ 10 ].…”

Perbedaan uji diagnostik antigen, antibodi, RT-PCR dan tes cepat molekuler pada Coronavirus Disease 2019

“…Berdasarkan studi analisis yang dilakukan oleh para epidemiologis menunjukkan bahwa penyebaran penyakit ini diperkirakan terkait dengan Pasar Makanan Laut Cina Selatan di Wuhan. Pada bulan Januari 2020, World Health Organization (WHO) memberi virus ini nama baru yaitu SARS-COV-2 dan penyakitnya yaitu COVID-19 [1] . Jumlah kematian yang terkait dengan COVID-19 saat ini sangat melampaui dua coronavirus sebelumnya (SARS-CoV dan MERS-CoV), dan wabah ini masih berlangsung, yang merupakan ancaman besar bagi kesehatan dan ekonomi masyarakat global.…”

“…WHO tidak merekomendasikan penggunaan tes diagnostik cepat berbasis deteksi antibodi untuk perawatan pasien, namun tes ini dapat membantu dalam surveilans penyakit dan penelitian epidemiologis. [1] B. ELISA…”

Inclusion of Cephalexin in COVID-19 Treatment Combinations May Prevent Lung Involvement in Mild Infections: A Case Report with Pharmacological Genomics Perspective

“…3 Diagnosis shall be confirmed by molecular tests (polymerase chain reaction [PCR]) and computed tomography (CT) scans and chest X-rays in case of lung involvement. 4 Reported mortality is different by countries and depends on the way they treat or people following the protocols. People with jobs in public sectors are the most at risk including doctors, nurses, bank tellers, public transport drivers, and others.…”