COVID-19 Pandemic and Male Fertility: Clinical Manifestations and Pathogenic Mechanisms

Abdel‐Moneim, Adel

doi:10.1134/s0006297921040015

Cited by 18 publications

(14 citation statements)

References 54 publications

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“…Specifically, very recently, Hajizadeh-Maleki and Tartibian (2021) [ 93 ] reported overproduction of apoptotic (caspases 3, 8, and 9), inflammatory (IL-1β, IL-6, IL-8, IL-10, TGF-β, TNF-α, IFN-α, and IFN-γ) markers associated with oxidative stress in seminal plasma of COVID-19 men. COVID-19 could thus lead to a reduction in sperm production and semen quality parameters through activation of the apoptosis and inflammation pathways most likely secondary to inflammasome activation [ 93 , 94 ]. A single case report very recently supports this assumption [ 95 ].…”

Section: Methodsmentioning

confidence: 99%

The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review

Tavalaee

Rahmani

Drevet

et al. 2022

Basic Clin. Androl.

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Background Infertility related to varicocele, infections, metabolic dysfunctions, oxidative stress and environmental toxicants is also associated with inflammatory processes that ultimately lead to the activation of the inflammasome pathway (IP). IP is classically activated by DAMPs, MAMPs or LAMPs, which stand for Damage-, Microbe- or Lifestyle-Associated Molecular Patterns, respectively. The most important player in IP activation is the NLRP3 (NOD[Nuclear oligomerization domain]-, LRR[Leucine rich repeat]- and pyrin domain-containing protein 3) which functions as an intracellular sensor of D/M/L-AMPs resulting in activation of caspase-1, promotion of apoptosis, pyroptosis and generation of inflammatory cytokines. This review addresses the question of whether IP activation might be associated with male infertility situations. Results & conclusions We conducted a systematic review of articles published in the Google Scholar, and PubMed databases through October 2021. It turns out that inflammasome activation and its consequences including cytokine storms, apoptosis and pyroptosis could be associated with the reduced sperm count as well as the structural and functional sperm defects recorded in several situations associated with male infertility suggesting that anti-inflammatory therapeutic strategies could be possibly considered to restore male fertility in future research.

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Section: Methodsmentioning

confidence: 99%

The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review

Tavalaee

Rahmani

Drevet

et al. 2022

Basic Clin. Androl.

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“…In patients with COVID-19, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were elevated, while testosterone and dihydrotestosterone levels markedly decreased. 393 In recovered male patients, the count, concentration and motility of sperm were still declined slightly, although sexual hormones have returned to normal levels. 394 Patients with a longer recovery time showed poorer sperm quality.…”

Section: Extrapulmonary Complicationsmentioning

confidence: 99%

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Ning

Wang

et al. 2022

Sig Transduct Target Ther

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The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a major threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also result in multiple extrapulmonary complications. The pathogenesis of extrapulmonary damage in patients with COVID-19 is probably multifactorial, involving both the direct effects of SARS-CoV-2 and the indirect mechanisms associated with the host inflammatory response. Recognition of features and pathogenesis of extrapulmonary complications has clinical implications for identifying disease progression and designing therapeutic strategies. This review provides an overview of the extrapulmonary complications of COVID-19 from immunological and pathophysiologic perspectives and focuses on the pathogenesis and potential therapeutic targets for the management of COVID-19.

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“…This cellular invasion disrupts the reproductive glands and may harm the gametes [ 177 ]. Men are considered more vulnerable to COVID-19 and have a greater death rate than women [ 178 ].…”

Section: Sars-cov-2 and Reproductive Systemmentioning

confidence: 99%

SARS‐CoV‐2 infection and multi-organ system damage: a review

Rabaan

Smajlović

Tombuloğlu

et al. 2022

Bosn J of Basic Med Sci

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The BJBMS publishes an "Advanced online" manuscript format as a free service to authors in order to expedite the dissemination of scientific findings to the research community as soon as possible after acceptance following peer review and corresponding modification (where appropriate). An "Advanced online" manuscript is published online prior to copyediting, formatting for publication and author proofing, but is nonetheless fully citable through its Digital Object Identifier (doi®). Nevertheless, this "Advanced online" version is NOT the final version of the manuscript.

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COVID-19 Pandemic and Male Fertility: Clinical Manifestations and Pathogenic Mechanisms

Cited by 18 publications

References 54 publications

The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review

The NLRP3 inflammasome: molecular activation and regulation in spermatogenesis and male infertility; a systematic review

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

SARS‐CoV‐2 infection and multi-organ system damage: a review

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