Covalently cross-linked poly(2-oxazoline) materials for biomedical applications – from hydrogels to self-assembled and templated structures

Hartlieb, Matthias; Kempe, Kristian; Schubert, Ulrich S.

doi:10.1039/c4tb01660b

Cited by 75 publications

(53 citation statements)

References 101 publications

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“…One of the milestones in tissue engineering has been the development of 3D scaffolds that guide cells to form functional tissue . To achieve the aim of tissue reconstruction, scaffold material should be biocompatible and have good mechanical properties . A high porosity and an adequate pore size are also necessary to allow for cell seeding and diffusion of nutrients .…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Liu

Shen

et al. 2017

Macro Materials & Eng

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Biodegradable hydrogels have attracted much attention in tissue engineering due to their good biocompatibility and elastomeric behavior. In this work, a series of inorganic–organic polyhedral oligomeric silsequioxanes–poly(ethylene glycol) (POSS–PEG) hybrid hydrogels are prepared by covalently grafting POSS into PEG and further cross‐linked by matrix metalloproteinase (MMP) degradable peptide via Michael‐type addition polymerization. All the POSS–PEG hybrid hydrogels have a porous structure and high hydrophilic ability, and the grafted hydrophobic POSS macromers result in a higher mechanical properties and lower equilibrium swelling ratio. Additionally, the hydrogels can be biodegraded by MMP‐2 solution and the POSS loading level can influence the degradation rate. It is worth mentioning that POSS‐containing hybrid hydrogels can be prepared in water and be used for 3D cell culture. In vitro cell viability study on human umbilical vein endothelial cells for 3D cell culture indicates POSS–PEG hydrogels have good compatibility. All of these results suggest that these POSS–PEG hybrid hydrogels exhibit the potential for tissue engineering scaffolds.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Liu

Shen

et al. 2017

Macro Materials & Eng

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“…[18][19][20] Biostable/biocompatible APCNs have also been used for the preparation of immunoisolatory devices. It is noted that hydrogels have also been successfully used as tissue engineering scaffolds 26 and in regenerative medicine. APCN gel is a modified version of a hydrogel which is useful for the controlled release of both hydrophilic and hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Degradable/cytocompatible and pH responsive amphiphilic conetwork gels based on agarose-graft copolymers and polycaprolactone

et al. 2015

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Amphiphilic conetwork (APCN) gels have emerged as an important class of biomaterials due to their diverse applications. APCN gels based on biocompatible/biodegradable polymers are useful for controlled release and tissue engineering applications. Herein, we report a facile synthesis of APCN gel films by click type sequential nucleophilic substitution reaction between pendent tertiary amine groups of agarose-g-poly(methyl methacrylate)-b(co)-poly(2-dimethylamino)ethyl methacrylate [Agr-g-PMMAb(co)-PDMA] copolymers and activated benzyl chloride groups of polychloromethyl styrene or benzyl methyl chloride terminated polycaprolactone. A linear triblock copolymer (PDMA-b-PMMA-b-PDMA) containing a central PMMA block and end PDMA blocks was also employed for the synthesis of APCN gels for comparison purposes. These APCN gels exhibit co-continuous nanophase morphology, pH responsive water swelling and pH triggered release of hydrophobic and hydrophilic drugs. These gels are biodegradable/cytocompatible as confirmed by MTT assay and hemolysis experiment. The degraded species undergo micellization in aqueous environment and display a low critical micelle concentration.Milled APCN gel particles are injectable through a hypodermic syringe. This synthesis approach is extremely useful for the preparation of a library of APCN gels of diverse architectures and compositions for biomedical applications.

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“…Therefore, a series of bioinert polymers have been developed as substitutes for PEG. Among them, poly(2-methyl-2-oxazoline) (PMOXA) has attracted increasing interest for its high-hydrophilicity and biocompatibility [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Stable antifouling coatings by hydrogen-bonding interaction between poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) and poly(acrylic acid)

et al. 2015

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Surface modified with so-called protein-repellent or antifouling polymers has become indispensable for the development of modern therapeutic and diagnostic medical devices. In this work, a series of novel well-defined poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) (PMOXA-b-P4VP) diblock copolymers were synthesized by using copper-catalyzed azide-alkyne cycloaddition reaction of a-alkynyl-PMOXA and x-N 3 -P4VP, in which a-alkynyl-PMOXA and x-N 3 -P4VP were prepared by cationic ring opening polymerization and atom transfer radical polymerization, respectively. Stable coatings were formed when dropping PAA solution on the top of PMOXA-b-P4VP pre-coatings, due to hydrogen-bonding interaction between P4VP and poly(acrylic acid) (PAA). The long-term stability of these PMOXA-b-P4VP/ PAA coatings showed that increasing PMOXA chain length can improve not only the hydrophilicity but also the stability of the coatings. This simple method can form stable coatings on either inorganic (such as, silicon wafer and coverslip) or organic material [such as, poly(methyl methacrylate) sheet] surface. At the same time, for the high-hydratability of PMOXA chains, these crosslinked coatings showed well protein-resistant and platelet/cellrepellent properties, and the antifouling properties and long-term availability were enhanced increasing PMOXA polymerization degree.

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Covalently cross-linked poly(2-oxazoline) materials for biomedical applications – from hydrogels to self-assembled and templated structures

Cited by 75 publications

References 101 publications

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Biodegradable Inorganic–Organic POSS–PEG Hybrid Hydrogels as Scaffolds for Tissue Engineering

Degradable/cytocompatible and pH responsive amphiphilic conetwork gels based on agarose-graft copolymers and polycaprolactone

Stable antifouling coatings by hydrogen-bonding interaction between poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) and poly(acrylic acid)

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