Stable antifouling coatings by hydrogen-bonding interaction between poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) and poly(acrylic acid)

Abstract

Surface modified with so-called protein-repellent or antifouling polymers has become indispensable for the development of modern therapeutic and diagnostic medical devices. In this work, a series of novel well-defined poly(2-methyl-2-oxazoline)-block-poly(4-vinyl pyridine) (PMOXA-b-P4VP) diblock copolymers were synthesized by using copper-catalyzed azide-alkyne cycloaddition reaction of a-alkynyl-PMOXA and x-N 3 -P4VP, in which a-alkynyl-PMOXA and x-N 3 -P4VP were prepared by cationic ring opening polymerization and atom transfer radical polymerization, respectively. Stable coatings were formed when dropping PAA solution on the top of PMOXA-b-P4VP pre-coatings, due to hydrogen-bonding interaction between P4VP and poly(acrylic acid) (PAA). The long-term stability of these PMOXA-b-P4VP/ PAA coatings showed that increasing PMOXA chain length can improve not only the hydrophilicity but also the stability of the coatings. This simple method can form stable coatings on either inorganic (such as, silicon wafer and coverslip) or organic material [such as, poly(methyl methacrylate) sheet] surface. At the same time, for the high-hydratability of PMOXA chains, these crosslinked coatings showed well protein-resistant and platelet/cellrepellent properties, and the antifouling properties and long-term availability were enhanced increasing PMOXA polymerization degree.

Robust, Solvent-Free, Catalyst-Free Click Chemistry for the Generation of Highly Stable Densely Grafted Poly(ethylene glycol) Polymer Brushes by the Grafting To Method and Their Properties

“…Antifouling properties of the obtained brushes with three different molecular weights were assessed following a previously reported protocol. 29 Initially, the PEG brush modified substrates were equilibrated in PBS buffer (pH 7.4) for 2 h and then immersed in a solution of BSA-FITC (0.25 mg/mL in PBS) at room temperature. Two hours later, the substrates were rinsed with PBS buffer and then DI water before being dried with argon.…”

Hybrid Multiblock Copolymers of 2-Oxazoline and Acrylates via Cu-Catalyzed Azide–Alkyne Cycloaddition Step-Growth Mechanism

“…3 For instance, initiating the chain with propargyl tosylate introduces an alkynyl functionality at the α-end that can be used for CuAAC post-polymerization functionalization or thiol−yne reactions. 4 Alternatively, the growing chain end can be terminated with acrylic acid, installing an alkenyl functionality on the chain end, which can subsequently be reacted in a thiol−ene reaction for polymer−polymer coupling. 5 Additionally, the side group of 2-oxazoline can be utilized to introduce functional groups, which allow for tuning the physical properties of the polymer.…”

“…The use of functional initiators and a broad range of terminating agents allow for a variety of functionalities to be introduced at the poly­(2-oxazoline) chain ends, which can further undergo postpolymerization reactions . For instance, initiating the chain with propargyl tosylate introduces an alkynyl functionality at the α-end that can be used for CuAAC post-polymerization functionalization or thiol–yne reactions . Alternatively, the growing chain end can be terminated with acrylic acid, installing an alkenyl functionality on the chain end, which can subsequently be reacted in a thiol–ene reaction for polymer–polymer coupling .…”

A binary mixed polymer brush coating with adjusted hydrophobic property to control protein adsorption

“…hydrophilicity and biocompatibility) to PEG and less degradation than PEG. [25][26][27][28][29] Cavallaro and coworkers reported that the films developed via plasma deposition of 2-methyl-2-oxazoline (MOXA) could resist the adsorption of Staphylococcus epidermidis and cells by more than 90% regardless of the type of substrate used. 30 Bai and coworkers developed poly(2-methyl-2-oxazoline-random-glycidyl methacrylate) (PMOXA-r-GMA) comb copolymers.…”