Degradable/cytocompatible and pH responsive amphiphilic conetwork gels based on agarose-graft copolymers and polycaprolactone

Abstract

Amphiphilic conetwork (APCN) gels have emerged as an important class of biomaterials due to their diverse applications. APCN gels based on biocompatible/biodegradable polymers are useful for controlled release and tissue engineering applications. Herein, we report a facile synthesis of APCN gel films by click type sequential nucleophilic substitution reaction between pendent tertiary amine groups of agarose-g-poly(methyl methacrylate)-b(co)-poly(2-dimethylamino)ethyl methacrylate [Agr-g-PMMAb(co)-PDMA] copolymers and activated benzyl chloride groups of polychloromethyl styrene or benzyl methyl chloride terminated polycaprolactone. A linear triblock copolymer (PDMA-b-PMMA-b-PDMA) containing a central PMMA block and end PDMA blocks was also employed for the synthesis of APCN gels for comparison purposes. These APCN gels exhibit co-continuous nanophase morphology, pH responsive water swelling and pH triggered release of hydrophobic and hydrophilic drugs. These gels are biodegradable/cytocompatible as confirmed by MTT assay and hemolysis experiment. The degraded species undergo micellization in aqueous environment and display a low critical micelle concentration.Milled APCN gel particles are injectable through a hypodermic syringe. This synthesis approach is extremely useful for the preparation of a library of APCN gels of diverse architectures and compositions for biomedical applications.

Characterization of a chitosan‐based sustained release nanofertilizer formulation used as a soil conditioner while simultaneously improving biomass production of Zea mays L.

“…In order to study the release characteristics, the procedure described by Bera, Singh Chandel, Uday Kumar & Jewrajka (2015) was followed. Briefly, release of potassium from CNK was studied with the help of its diffusion through semipermeable membrane (Sigma‐Aldrich) having 2 kDa pore size in deionized water as it can selectively block the diffusion of CN from CN or CNK, while allowing the potassium to pass through.…”

Antimicrobial Biomaterial on Sutures, Bandages and Face Masks with Potential for Infection Control

“…Cinnamic acid and its derivatives are increasingly used to design novel antimicrobial biomaterials within polymeric matrices [ 80 , 81 , 82 ]. Biodegradable, hydrophilic materials with antifouling and wound-healing abilities support tissue repair processes [ 83 , 84 , 85 , 86 , 87 ]. AV has stabilizing and moisturizing purposes, in addition to its anti-inflammatory qualities.…”

Modular design and self-assembly of multidomain peptides towards cytocompatible supramolecular cell penetrating nanofibers

“…Engineering polymer degradability has been used as an effective method to improve the cytocompatibility of cell penetrating polymers. [43][44][45][46] The cytotoxicity of these supramolecular peptides was evaluated in HeLa cell culture and the cell viability was quantied by the CCK8 assay aer 24 h of incubation of cells with each peptide. As shown in Fig.…”