Covalently construction of poly(hexamethylene biguanide) as high-efficiency antibacterial coating for silicone rubber

Surface Design for Antibacterial Materials: From Fundamentals to Advanced Strategies

“…Bacterial contamination and its related infections pose a severe threat to hospitals, food industry, and community settings. [17] Although antibiotics and sterile conditions are widely used, there are still a large number of patients suffering from biomaterialrelated infections, thus resulting in biomedical devices' failure. We have used the terms "adhesion" and "attachment" to describe the different stages about the interaction between bacteria and material surface.…”

Antimicrobial Coating: Tracheal Tube Application

“… 36 In addition, a covalent construction of polyhexamethylene biguanide (PHMB) as an efficient bactericidal coating on silicone rubber (SR) could kill 100% of Staphylococcus aureus cells within one hour with an initial density of less than 1.18×105 CFU/cm2 without affecting the cytocompatibility of the substrate. 37 At the same time, the coating dramatically increases the mechanical properties of the SR substrate due to the additional cross-linking introduced by the coating. 37 The synergistic anti-biofilm activity of citral and thymol was recently demonstrated, and without altering the growth and metabolic viability of methicillin-resistant Staphylococcus aureus , the anti-biofilm activity of the coating was unaffected by plasma modulation.…”

“… 37 At the same time, the coating dramatically increases the mechanical properties of the SR substrate due to the additional cross-linking introduced by the coating. 37 The synergistic anti-biofilm activity of citral and thymol was recently demonstrated, and without altering the growth and metabolic viability of methicillin-resistant Staphylococcus aureus , the anti-biofilm activity of the coating was unaffected by plasma modulation. In addition, the anti-biofilm coating was non-hemolytic and non-toxic to peripheral blood mononuclear cells.…”

Zwitterionic/phosphonate copolymer coatings endow excellent antifouling properties and robust re-mineralization ability of dentine substrates

“…Combined together, these data clearly indicated that the surface-immobilized zwitterionic pMPC polymer can endow good antifouling ability to the dental hard tissues, mainly due to the intrinsic excellent antifouling ability of zwitterionic polymers. [32][33][34][35] The higher content of the zwitterionic pMPC component in the coating polymer, the better antifouling properties could be endowed to the dentine substrates.…”

“…Zwitterion polymers including poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC), 20,21 poly(sulfobetaine) (pSB), 22 poly(carboxybetaine) (pCB) 23 and N-oxide-derived polymers 24 are well-known antifouling materials. 25 Due to their ability to inhibit the initial protein adsorption, zwitterion surfaces have been constructed on diverse substrates that is able to inhibit the bacterial adhesion and the consequent biofilm formation [26][27][28][29][30][31][32][33][34] even for long-term applications. 35 Beyond the excellent antifouling properties, zwitterionic polymers have been identified as a type of novel high-efficiency biomineralization ligands for calcium phosphate because of their oppositely charged motifs that can mimic the synergistic effect of the positively and negatively charged residues of an extracellular matrix during the natural biomineralization of bone tissues.…”