Course of oral lichen planus: a retrospective study of 808 northern Italian patients

Carbone, M; Arduino, Paolo Giacomo; Carrozzo, Marco; Gandolfo, S; Argiolas, Federico; Bertolusso, Giorgio; Conrotto, Davide; Pentenero, Monica; Broccoletti, Roberto

doi:10.1111/j.1601-0825.2009.01516.x

Cited by 223 publications

(258 citation statements)

References 38 publications

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“…The clinical profile of the OLP patients in this study shares many similarities with those reported by other authors, in terms of female predominance (female/male ratio 3.8:1), age of diagnosis (predominantly over 50 years) and the clinical pattern of the lesions (predominance of the reticular form with bilateral distribution) (4,(13)(14)(15).…”

Section: Discussionsupporting

confidence: 70%

“…This finding does not agree with a general tendency in the literature to associate the erosive form with DILR intake, but it is in agreement with the results of a large study involving 808 OLP patients (15), where the authors did not find a predominance of the erosive form in patients taking ACE inhibitors. So, while there is no disagreement among authors that some drugs can cause LDR lesions, in light of the present study and others (15,16), it seems that the prevalence of LDR lesions is low. It is also generally agreed that OLP affects predominantly women, possibly suggesting a genetic predisposition to the development of OLP.…”

Section: E756supporting

confidence: 70%

“…The female predominance reported in the present study was even higher than those found in other studies (4,10,(14)(15)(16), in which the female/male ratio varied from 1.5:1 to 2.1:1. One possible explanation for this difference is that, routinely, more women (64.5%) than men (35.5%) come to our clinic for a diagnosis of some type oral mu- (3,9,17).…”

Section: Discussioncontrasting

confidence: 56%

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Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Hirota

Moreno²,

Santos³

et al. 2011

Med Oral

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Objectives: To investigate whether daily systemic and/or topical medication contributes to the development of oral lichen planus (OLP) lesions. Study Design: The study involved 110 OLP patients and 76 control subjects, matched by age, race and sex. The analyzed data included medical records, drug intake and topical medication. Criteria for analysis of drug intake included: (1) ATC-code drug classification; (2) number of different drugs used daily in the categories of monopharmacy (1 drug), minor polypharmacy (2-4 drugs), and major polypharmacy (> 5 drugs); and (3) drugs implicated in lichenoid reactions (DILRs). Results: Sixty (54.5%) of the 110 OLP patients reported daily medication (prior to the appearance of the OLP lesion) compared to 52 (68.4%) of the 76 control subjects. No statistical difference was found between the two groups in terms of systemic diseases, number of medicated individuals in the categories of mono-and polypharmacy, nor use of DILRs (P > 0.05). Regarding the clinical forms and site of involvement, a statistically significant difference was only found for the clinical erosive form of OLP, seen more frequently in non-DILR (P = 0.04) and nonmedicated OLP patients (P = 0.02) than in DILR OLP patients. Daily use of topical oral medication was reported by 2 (1.8%) OLP patients and 1 (1.3%) control subject. Conclusions: It seems that the use of systemic medication does not lead to a significant increase in the incidence of OLP lesions. For their part, lichenoid drug reactions are likely to occur only in a very low percentage of patients.

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Section: Discussionsupporting

confidence: 70%

Section: E756supporting

confidence: 70%

Section: Discussioncontrasting

confidence: 56%

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Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Hirota

Moreno²,

Santos³

et al. 2011

Med Oral

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“…Oral lichen planus (OLP) is a relatively common chronic inflammatory disease, of unknown aetiology, rarely undergoing spontaneous remission and potentially premalignant [1]. OLP is difficult to palliate and in several cases, most therapies are merely symptomatic [2]; even if the best treatment remains high-potency topical corticosteroids, management is usually empirical, without adequate control groups or corrected study designs [3].…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

et al. 2013

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This is an author version of the contribution published on:Questa è la versione dell 'autore dell'opera: Lasers Med Sci. 2014 Jan;29(1):185-90. doi: 10.1007/s10103-013-1313 The definitive version is available at:La versione definitiva è disponibile alla URL: http://link.springer.com/article/10.1007URL: http://link.springer.com/article/10. /s10103-013-1313 Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series. Eighty-two lesions were treated. We reported significant reduction in clinical scores of the treated lesions and in reported pain. No detailed complications or therapy side effects were observed during the study. AdrianaAs previously reported by our group with a preliminary report, this study suggests that LLLT could be a possible treatment choice for patients with unresponsive symptomatic OLP, also reducing the possible invasiveness correlated with other therapies.

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“…Mucosal lesions in OLP are chronic, considered to be a potentially premalignant, hardly ever undergo spontaneous remission and frequently impair patient's wellbeing [1]. Recent epidemiological studies have shown varying prevalence of 0.1-4% cases; mostly without distinguish between the OLP and oral lichenoid lesions (OLL) [2].…”

Section: Introductionmentioning

confidence: 99%

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

Čanković¹

2016

J. Dent. Sci. Ther

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Oral lichen planus (OLP) is a still poorly understood and relatively common chronic inflammatory disease of oral mucosa. A connection between OLP and certain diseases have been reported in the past, such as diabetes, hypertension, hepatitis C infection (HCV), thyroid disease, and malignant diseases. There is some controversial about mentioned link with OLP. The study objective was to investigate association between autoimmune diseases and OLP in Northern Serbian province. A total of 48 patients (33 females and 15 males, ranged 29-84 years, mean age 59.8 ± 13.0) with clinical and histopathological proven OLP, along with 71 matched controls without oral mucosa lesions were included in the study. This was a retrospective case-control study conducted in patients who were treated at the Dental Clinic, Faculty of Medicine, University of Novi Sad, between January 2010 and Jun 2016. Clinical characteristics of OLP lesions, other oral mucosal diseases, presence of cutaneous LP, medical and family history with special regard to their autoimmune diseases with medication intake were recorded. Association regarding total of autoimmune diseases was found significant especially in prevalence of thyroid gland diseases. This study indicates connection between thyroid gland disorders (Hashimoto thyroiditis) and OLP. There is a need for further investigations such a screening for asymptomatic OLP in woman over the 40 years old suffering from thyroid gland disorders, particularly hypothyroidism.

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Course of oral lichen planus: a retrospective study of 808 northern Italian patients

Cited by 223 publications

References 38 publications

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Analysis of a possible association between oral lichen planus and drug intake. A controlled study

Clinical evaluation of the efficiency of low-level laser therapy for oral lichen planus: a prospective case series

Association of Oral Lichen Planus with Autoimmune Diseases in A Northern Serbia Population: Matched Case-Control Study and Literature Review

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