Many factors have been proposed to influence oral infection with yeast. The aim of this study was to determine the prevalence of oral yeasts in oral lichen planus (OLP) patients and control subjects, and to perform a multiple logistic regression analysis to identify factors that influence oral Candida infection in OLP patients. In this cross-sectional study, 90 new patients with OLP and 90 sex- and age-matched control subjects with no mucosal lesions were interviewed about their health status, use of medication, and smoking and alcohol habits. Swab and unstimulated whole saliva samples were collected and salivary pH was measured. A positive Candida culture was more prevalent among OLP patients (48.9%) than among control subjects (26.7%). Candida albicans was the most frequently isolated species in both groups. By logistic regression analysis, unstimulated whole salivary flow rates of 0.11-0.24 ml min(-1) (OR = 5.90) and 0.25-0.32 ml min(-1) (OR = 3.51) and benzodiazepine anxiolytics intake (OR = 8.30) were independently associated with the presence of Candida among OLP patients. Age, denture wearing, levels of dentition, decreased salivary pH, antihypertensive drugs, and alcohol consumption were not associated with oral Candida infection in OLP patients. The results indicate that data on benzodiazepine anxiolytics intake and evaluation of unstimulated whole salivary flow rate should be considered as part of the clinical evaluation to identify OLP patients at risk for Candida infection.
Histological abnormalities of clinically normal-looking oral mucosa taken at different distances from the tumor lesion indicated the existence of subclinical field change and represent an important parameter during the assessment of the adequacy of surgical resection margins in oral cancer management.
Bacground/Aim. Systemic candidiasis in intensive care units remains an improtant problem due to antifungal resistance. Patients undergoing radiotherapy for head and neck cancer are at increased risk of developing oral candidiasis and they more frequent have prior fungi colonization. Due to identification of specific risk factors predisposing to fungal infection in order to threat such patients the aim of this study was to determine the presence of Candida species in patients with oral squamous cell carcinoma and compare it to the control subjects (patients with benign oral mucosal lesions). Methods. A total number of 30 consecutive oral cancer examined patients were included in this prospective study (24 men and 6 women with a mean age of 61.47 years, range 41-81 years). The control group consisted of 30 consecutive patients with histologically proven benign oral mucosal lesions (16 men and 14 women with a mean age of 54.53 years, range 16- 83 years). The samples for mycological examination were obtained by using sterile cotton swabs from the cancer lesion surface and in the patients of the control group from the benign mucosal lesion surface. Samples were inoculated in Sabouraud' dextrose agar. For identification purposes, Mackenzie germ tube test was performend on all isolates. Results. The prevalence of Candida was significantly higher in oral cancer patients than in control subjects (χ2 = 5.455, p = 0.020). Candida was found on nine of the 30 cancer surfaces; 5 (16.7%) were identified as non-albicans Candida and 4 (13.3%) as Candida albicans. In the control group, only Candida albicans was isolated from 2 (6.7%) patients. In this study, no statistically significant differences in the presence of Candida species was found with respect to gender, age, smoking, alcohol consumption, wearing of dental protheses and the site of cancer lesion. Conclusion. The increased prevalence of yeasts on the surfaces of oral carcinoma indicates a need for their suppression before any cancer treatment. There was no evidence for an association between gender, age, smoking, alcohol consumption, wearing of dental protheses, the site of cancer lesion and the yeast presence
Background:The aim of the study was to determine the microbial presence and type in the biofilms present on the surface of oral squamous cell carcinomas and benign lesions of oral mucosa.Methods: Thirty new (untreated) patients with oral squamous cell carcinoma were examined. The control group consisted of thirty subjects with benign lesions of oral mucosa. Swab samples were taken from the superficial layer of the carcinoma and benign lesions for bacteriological examination. Swabs were transported within 2 hours and immediately sown and incubated. Oral health index was assessed in all patients. Results:The prevalence of pathological bacterial microflora was significantly higher in cancer patients (p<0.01). No significant associations were found between bacterial presence and gender, localization, cigarette smoking, alcohol consumption and denture wearing (p>0.05). Poor oral hygiene was also registered in cancer patients. Conclusion:Possibility of microflora retention on irregular oral carcinoma surface possibly contributes to chronic inflammation often observed on the surface of oral carcinomas.
Background The Oral Health Impact Profile-14 (OHIP-14) was designed to assess patients’ perception of the impact of oral disorders on their quality of life (QoL). Although the OHIP-14 is now frequently used in patients with head and neck cancer, data related to its measurement properties in this population are scarce. The aim of the present study was to evaluate the reliability and validity of the OHIP-14 in a sample of Serbian patients with head and neck cancer. Material and Methods Data were available for 345 patients (257 [74.5%] males; aged 30-92 years), with head and neck cancer. All patients completed the OHIP-14 and the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and QLQ-H&N35. Factor analyses, internal consistency reliability (i.e., Cronbach’s α coefficient), and construct validity were analyzed. Results The factor analyses confirmed that 14 OHIP items were measuring a single underlying factor. Cronbach’s α coefficient was 0.98 and corrected item-total correlations ranged 0.77-0.93. Lower OHIP-14 scores (i.e., lower impacts on oral health) were more frequently present among patients who had only surgery as a therapeutic procedure compared to those who had surgery accompanied with radio- and chemotherapy ( p < 0.01). Patients with a tumor stage 0-II also had lower OHIP-14 scores compared to those who had a tumor stage III-IV ( p < 0.01). The OHIP-14 correlated significantly with the QLQ-C30 and QLQ-H&N35 scales. Conclusions As a unidimensional instrument, the OHIP-14 provides oral QoL assessments with sound internal consistency reliability and construct validity among patients with head and neck cancer. Key words: Quality of life, oral health, psychometrics, reliability, validity.
Background/AimThe aim of this study was to determine the link between dental visits and independent sociodemographic factors and smoking in the adult population in Serbia.Methods This cross-sectional study represents an analysis of 2013 National Health Survey for the population of Serbia (without data of Kosovo and Metohia population). Study included 13,404 adults 20 years and over. The mean age of participants was 51.7 years including 7,221 females (53.9%) and 6,183 males (46.1%). In order to determine possible predictors of a dental visit the multivariate logistic regression model was implemented.Visit to a dentist was dependent variable while the independent variables were: sex, age, marital status, type of settlement, region, education, employment status, Wealth Index and smoking status. Results Significant differences were observed between categories of dental visit and all independent variables except marital and smoking status. In multivariate model odds of visiting dentist in period "12 months or longer" vs. "in last 6 months" were the highest among older respondents (OR=1.03; 95%CI=1.02-1.04), from rural area (OR=1.17; 95%CI=1.03-1.32), with low (OR=2.55; 95%CI=2.12-3.07) and middle (OR=1.76; 95%CI=1.54-2.00) education level, unemployed (OR=1.20; 95%CI=1.06-1.37), who belong to poorer (OR=1.30; 95%CI=1.08-1.54) or the poorest class (OR=1.71; 95%CI=1.38-2.12) and smokers (OR=1.13; 95%CI= 1.01-1.26). Conclusion Study demonstrated that sociodemographic factors and smoking are important factors related to visit to a dentist. This study can help to advance regular visits to a dentist and programs of health education focusing on oral health and smoking cessation as well.Key words: visit to a dentist, adults, sociodemographic factors, smoking Apstrakt Uvod/Cilj Cilj ove studije bio je utvrĎivanje povezanosti izmeĎu posete stomatologu i nezavisnih socio-demografskih faktora i pušenja kod odrasle populacije u Srbiji. Metode Istraživanje predstavlja analizu podataka dobijenih u okviru Nacionalnog istraživanja zdravlja stanovništva Srbije koje je sprovedeno 2013. godine kao studija preseka na reprezentativnom uzorku odraslog stanovništva Srbije (bez podataka o stanovništvu Kosova i Metohije). Studija je obuhvatila 13404 ispitanika starosti 20 godina i više. Prosečna starost ispitanika bila je 51,7 godina, uključujući 7221 ženu (53,9%) i 6183 muškarca (46,1%). Prediktori učestalosti posete stomatologu analizirani su 4 multivarijantnom logističkom regresijom. Poseta stomatologu je bila zavisna promenljiva, dok su nezavisne promenljive bile: pol, starost, bračni status, tip naselja, region, obrazovanje, radni status, indeks blagostanja i pušački status. Rezultati Postoje značajne razlike izmeĎu kategorija posete stomatologu i svih nezavisnih promenljivih osim bračnog i pušačkog statusa. Rezultati multivarijantnog modela pokazali su da su šanse za posetu stomatologu u periodu "12 meseci ili duže" u odnosu na "u poslednjih 6 meseci" bile najveće kod starijih ispitanika (UO=1,03; 95%IP=1,02-1,04), onih koji žive u naselj...
Prevalence and possible predictors of the occurence of denture stomatitis in patients older than 60 years Prevalencija i mogući prediktori nastanka protetskog stomatitisa kod pacijenata starijih od 60 godina Abstract Background/Aim. Denture stomatitis (DS) is one of the most common oral health problems among elderly population with removable dentures. Despite the high prevalence, etiology of the disease is not completely understood. It appears to be multifactorial, with a predominance of local factors. The aim of the study was to determine the prevalence and risk factors that contribute to the development of DS in upper removable denture wearers. Methods. This clinical study comprised three groups of subjects with upper removable dentures: the DS group, and the positive and negative control groups. Swab samples were taken from the tongue and palatal mucosa for microbiological examination. Data of denture age, dentures night wearing, unstimulated salivary flow rate (US-FR) and saliva pH values were evaluated for all the participants. Results. The prevalence of DS was found to be 26.5%. Significantly higher values of overnight wearing (p = 0.000) and the mean age of dentures (p = 0.022) were found in the DS group compared to the controls. In relation to the positive mycological finding, a borderline significance difference among the groups was confirmed (p = 0.053). No significant association was found between DS and gender, age, the type of dentures, USFR, pH of saliva and bacteria findings. The patients who wore dentures at night had 26 times more chances to get DS compared to the patients who did not wear them overnight. Conclusion. This study confirms similar characteristics of DS prevalence in elderly population of Vojvodina compared to European. Continuous (overnight) wearing of dentures is considered to be major direct risk factor for DS development, while secondary role is attributed to denture age and oral Candida infection. ApstraktUvod/Cilj. Protetski stomatitis (PS) jedno je od najčešćih oboljenja usne duplje kod starijih osoba sa mobilnim protezama. Uprkos velikoj rasprostranjenosti, etiologija oboljenja nije u potpunosti razjašnjena. Ona je verovatno multifaktorijalna, sa predominacijom lokalnih faktora. Cilj rada bio je da se utvrde prevalencija i faktori rizika koji doprinose nastanku PS kod nosilaca gornjih mobilnih proteza. Metode. Studija je obuhvatila tri grupe ispitanika sa gornjim mobilnim protezama: grupu sa PS, te pozitivnu i negativnu kontrolnu grupu. Brisevi jezika i nepca uzeti su za mikrobiološko ispitivanje. Za sve ispitanike utvrđivani su podaci o starosti proteza, noćnom nošenju proteza, sijalometriji i pH vrednosti pljuvačke. Rezultati. Prevalencija PS iznosila je 26,5%. Utvrđena je statistički značajna razlika između grupe sa PS i kontrolnih grupa u odnosu na noćno nošenje proteza (p = 0,000) i prosečne starosti proteza (p = 0,022). Pozitivan mikološki nalaz u granicama statističke značajnosti (p = 0,053) utvrđen je kod pacijenata sa PS. Nije utvrđena značajna povezanost između prot...
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