Course and Prognosis in Amyotrophic Lateral Sclerosis

Mackay, Roland P.

doi:10.1001/archneur.1963.00460020017001

Cited by 113 publications

(27 citation statements)

References 8 publications

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“…In our sample only 5 patients (12.2%) were under 45. In our survey the mean age at onset of the disease was similar to that observed by other authors who ob tained values ranging between 50 and 60 years [4,9,22,30]. In agreement with the study of Bounduelle [3] and Bounduelle et al [4], the mean age at onset in our sample was closer to 60 than 50 years.…”

Section: Discussionsupporting

confidence: 92%

Amyotrophic Lateral Sclerosis: An Epidemiological Study in the Province of Messina, Italy, 1976–1985

et al. 1988

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An epidemiological investigation of 41 subjects with amyotrophic lateral sclerosis observed in the Province of Messina during 1976–1985 was performed. The incidence was 0.61/100,000 and the prevalence 2.48/100,000 inhabitants. The illness was found to be prevalent in males. The atrophic type occurred in 17 subjects, the bulbar type in 23 cases and the pseudo-polyneuritic form in only one patient. The mean age on the onset was 57.29 ± 10.55 years. The duration of the illness was significantly higher in patients with atrophic type (p < 0.01). No significant difference between occupation and development of the disease was found. Among all patients 12.19% presented evidence of trauma, but traumatic events were equally present in a control group.

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Section: Discussionsupporting

confidence: 92%

Amyotrophic Lateral Sclerosis: An Epidemiological Study in the Province of Messina, Italy, 1976–1985

et al. 1988

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“…In our series the M/F ratio is 2.3 : 1. Though higher than in some series [4,18,6,10] it agrees with others [13,2] and especially with [18]. Moreover we found the earliest onset in lumbar forms.…”

Section: Commentssupporting

confidence: 93%

“…They were especially useful in revealing signs of peripheral damage in clinically uninvolved muscles and thus suggesting the possibility of upper motor neuron damage through the study of the Hmax/Mmax ratio. We classified our patients according to the Mackay classification [13], partially modified, and distinguished three forms of ALS, depending on the site of onset of the disease: bulbar, when the first amyotrophic or pyramidal signs affected the bulbar muscles; cervical, when the first signs showed damage in the cervical cord with amyotrophy of the arms and/or pyramidal signs in the arms or in legs; lumbar, when the first sign was amyotrophy in the legs. In 95 out of the 116 cases the course of the illness was followed up thoroughly, whilst in 21 cases follow-up was not possible.…”

Section: Als Patients Hospitalized In the Neurologicalmentioning

confidence: 99%

Clinical features of amyotrophic lateral sclerosis

et al. 1981

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The clinical features and course of amyotrophic lateral sclerosis are discussed. The data on a series of 116 patients are compared with those of the literature. The following points emerge: 1) when the disease starts before the age of 50, the prognosis is often less poor than usual; 2) the forms with spinal, and especially cervical, onset appear to be less rapid than bulbar forms; 3) in 20% of the patients survival is over 5 years. There may be some unknown factor that increases the resistance of some subject to the disease.

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“…The clinical manifestations in patients with ALS have been extensively studied [45][46][47][48][49][50][51][52]. Kurland had reported a sex ratio of 1.5:1 reflecting the male preponderance.…”

Section: Comparison With Studies From Western Countriesmentioning

confidence: 99%