Amyotrophic Lateral Sclerosis: An Epidemiological Study in the Province of Messina, Italy, 1976–1985

Domenico, P. De; Malara, Carmelo E.; Marabello, L.; Puglisi, Rosa M.; Meneghini, Francesca; Serra, Salvatore; Gallitto, G.; Musolino, Rosa Fortunata

doi:10.1159/000110149

Cited by 23 publications

(3 citation statements)

References 13 publications

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“…However, there was a much greater difference in course between the bul bar and pseudopolyneuritic forms. In agree ment with other studies [11,21], we observed fourfold higher 5-year survival rates in those patients with onset of symptoms in the lower 158 Ncurocpidemiology 1996;15:153-160 limbs than in those with bulbar onset. Many authors also reported a significant difference between the survival of patients with spinal and those with bulbar onsets; the serious na ture of the bulbar forms has been pointed out [17][18][19][20]22], The mean age at onset was significantly higher in the bulbar forms than in the com mon forms of the disease.…”

Section: Discussionsupporting

confidence: 93%

Survival Prediction in Sporadic Amyotrophic Lateral Sclerosis

et al. 1996

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Amyotrophic lateral sclerosis is a progressive neurological disease of unknown etiology and fatal outcome. Patient management can be aided by careful assessment of prognostic factors. A prospective study of 158 patients was carried out to examine the prognostic significance of age and clinical form at onset. The overall 5-year survival rate was 14.7%. The higher the age was at first symptoms, the worse the prognosis. The bulbar and common forms had a worse prognosis than the pseudo-polyneuritic forms. After adjustment for age, the clinical form at onset remained a prognostic factor. In a multivariate analysis using the Cox model, these two factors remained independent despite the later onset of the bulbar forms. In view of the discrepancies between the different published studies, the evaluation of the survival of an individual patient is of doubtful value.

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Section: Discussionsupporting

confidence: 93%

Survival Prediction in Sporadic Amyotrophic Lateral Sclerosis

et al. 1996

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“…The age-adjusted incidence of 0.63 (95% C.I. 0.39-0.95) per 100,000 Person-years, standardized to the European population, fwnd in this area is slightly lower than the rates reported in most of previous studies performed in other Mediterranean countries such as Italy (Rosati et al, 1977;Bracco et al, 1979;Granien et al, 1981Granien et al, , 1988Giagheddu et al, 1983Giagheddu et al, , 1993Leone et al, 1983;De Domenico et al, 1988) and Israel (Kahana and Zilber, 1984), but is definitely lower than the rates observed in northern European Countries (Forsgren et al, 1983;Murros and Fogelholm, 1983;Gunnarson and Palm, 1984;Dean et al, 1994) and in the United States (Yoshida et a)., 1986; h e g e r s et al., 1991;Proctor et al, 1992) (Table 111). Indeed, in several areas of the western Pacific a much higher incidence rates have been found but in these cases some environmental factors seem to play an etiological role (Kurland and Mulder, 1954;Gajdusek, 1963;Araki et a/., 1974;Reed and Brody, 1975;Shiraki and Yase, 1975;Gajdusek and Salazar, 1982;Reed et al, 1987).…”

Section: Discussionmentioning

confidence: 52%

Incidence and prevalence of motor neuron disease in Coastal and Mountainous Regions, Croatia, 1984–1993. A preliminary survey

Zivadinov

Jurjević

Willheim

et al. 1997

Euro J of Neurology

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In the period 1984-1993, we carried out an incidence and prevalence study of motor neuron disease in Coastal and Mountainous Regions, Croatia. This was the first epidemiological study on motor neuron disease in Croatia. A total of 22 incident cases were identified. The crude annual incidence rate was 0.68 (95% confidence interval 0.43-1.03) per 100,000 person-years; 0.95 (95% confidence interval 0.60-1.43) per 100,000 person-years for men and 0.42 (95% confidence interval 0.26-0.63) per 100,000 person-years for women. The rate adjusted to the European population was 0.63 (95% confidence interval 0.39-0.95) per 100,000 person-years. The age-adjusted incidence in our population is similar to the rates, standardized to the European population, observed in Italy, but lower than recent rates in the US and northern European studies. On 31st December 1993, there were 18 prevalent cases. The prevalence adjusted to the European population was 5.24 (95% confidence interval 3.10-8.28) per 100,000 population. 1 Rates per 100,000 person-years. Coastal and Mountainous Region population estimates for 1993, 21991 Croatia total population as standard. 3European total population as standard. European Journal of Neurology. Vol4 1997 379 R. ZWADINOV ETAL of demonstrating a significant trend based on only 22 incident cases is very low.The prevalence of MND in the Coastal and Mountainous Region, Croatia age-adjusted to the European population, was 5.24 (95% C.I. 3.10-8.28) per 100,000 population.The prevalence for females, ranging from 2.5 to 3.0 per 100,000, reported in other recent epidemiological studies on MND (Granieri et Annegers et al., 1991;Dean et al., 1994) is similar to the prevalence found in this study, whereas the prevalence for males, which, in the studies cited above, ranges from 3.91 to 5.4 per 100,000, is markedly lower than the prevalence calculated for Croatian men (7.96 per 100,000). This may reflect the longer survival times in men than women in this study. Neurologica Scandanavica, 6 7 , 4 1 4 7 . Proctor SP, Feldman RG, Wolf PA, Brent B and Wartenberg D (1992) A perceived cluster of amyotrophic lateral sclerosis cases in a Massachusetts community. Neumepidemiology, 11, 277-281. Reed DM and Brody JA (1975) Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam, 1945-1972. I.

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“…Within the Caucasian population of Europe and North America, where most of the studies have been conducted, the lowest reported incidence of MND was 0.6 per 100.000 personyears in Italy, (De Domenice, et al 1988) and the highest reported was 2.4 per 100.000 personyears in Finland (Murros and Fogelholm.1983). However, a lower incidence rate of 0.3/100,000 person-years was reported among Asian population, in China, (Fong, et al 1996).…”

Section: Introductionmentioning

confidence: 99%

Motor Neuron Disease

Tallawy¹

2012

Neuromuscular Disorders

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Amyotrophic Lateral Sclerosis: An Epidemiological Study in the Province of Messina, Italy, 1976–1985

Cited by 23 publications

References 13 publications

Survival Prediction in Sporadic Amyotrophic Lateral Sclerosis

Survival Prediction in Sporadic Amyotrophic Lateral Sclerosis

Incidence and prevalence of motor neuron disease in Coastal and Mountainous Regions, Croatia, 1984–1993. A preliminary survey

Motor Neuron Disease

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