Clinical features of amyotrophic lateral sclerosis

Abstract

The clinical features and course of amyotrophic lateral sclerosis are discussed. The data on a series of 116 patients are compared with those of the literature. The following points emerge: 1) when the disease starts before the age of 50, the prognosis is often less poor than usual; 2) the forms with spinal, and especially cervical, onset appear to be less rapid than bulbar forms; 3) in 20% of the patients survival is over 5 years. There may be some unknown factor that increases the resistance of some subject to the disease.

Motor Neuron Disease and Heavy Manual Labor: An Epidemiologic Survey of Värmland County, Sweden

“…Nearly half of the patients had early bulbar symptoms which is close to double the usual reported frequency [24,[28][29][30][31][32], As in these surveys, sur vival lime was shorter among patients with bulbar onset. The frequency of familial cases was the same as previously reported [1],…”

Clinical characteristics and survival pattern of 1153 patients with amyotrophic lateral sclerosis: Experience over 30 years from India

“…The clinical manifestations in patients with ALS have been extensively studied [45][46][47][48][49][50][51][52]. Kurland had reported a sex ratio of 1.5:1 reflecting the male preponderance.…”

Role of Electromyography in Diagnosis of Clinically Suspected Cases of Amyotrophic Lateral Sclerosis (ALS): Experience from a Tertiary Care Hospital in Bangladesh

“…Men are affected more frequently than women; however, this sex discrepancy is not as pronounced in familial cases. The clinical feature of ALS in different regions of the world was studied extensively in the researches published by Gubbay et al(1985); Mortara et al(1981); David et al 1981) and Rosen (1978). It was noted that almost all the features including sex distribution, pattern of presentation, and most importantly prognosis varied from western population to indian population.…”