Motor Neuron Disease and Heavy Manual Labor: An Epidemiologic Survey of Värmland County, Sweden

Gunnarsson, Lars‐Gunnar; Palm, Russell

doi:10.1159/000110854

Cited by 64 publications

(53 citation statements)

References 19 publications

(28 reference statements)

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“…Värmland county had high mortality figures for both diseases. As mentioned above, parts of Värmland county have been pointed out before as high-risk zones for MS [17], and investigators [23,24] have also observed a high incidence of ALS in this region (Värmland, Skaraborg) in recent decades. This leads us to the question about the cause.…”

Section: Discussionmentioning

confidence: 73%

Distribution of Multiple Sclerosis in Sweden Based on Mortality and Disability Compensation Statistics

et al. 2002

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Previous studies have shown the Fennoscandian region to be a high-risk area for multiple sclerosis (MS). In order to investigate the distribution of MS in Sweden, mortality (1952–1992) and disability pensioning statistics (1971–1994) were studied. A total of 11,414 cases with a disability pension and 5,421 cases with MS on their death certificate were analysed according to county and time period and the results were compared with the mortality figures for amyotrophic lateral sclerosis (ALS) and disability pensioning statistics for Parkinson’s disease. We found increasing rates of both MS mortality and disability pensioning. Disability pensioning correlated well with mortality 10 years later (r = 0.42, p = 0.04). We also found a marked geographical variation. Värmland county had the highest mortality, with 14 out of its 16 municipalities having higher rates than the national mean. Unexpectedly, we found a high correlation between mortality due to MS and ALS (r = 0.60, p = 0.002).

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Section: Discussionmentioning

confidence: 73%

Distribution of Multiple Sclerosis in Sweden Based on Mortality and Disability Compensation Statistics

et al. 2002

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“…In addition, this study showed that MS mortality was very high in the county of Värmland in western Sweden during four decades [2]. Other reports had previously supported a high occurrence of MS in this area [3], and interestingly, yet another team had demonstrated a high incidence of ALS in the same region [4,5]. …”

Section: Introductionmentioning

confidence: 62%

“…Exceptions are cigarette smoking [9,10] and exposure to organic solvents [11,12,13]. Other risk factors mentioned for MS are Epstein-Barr virus, vitamin D deficiency, female gender, and ethnicity [14] and for ALS, heavy manual labor [5]. There is also, to our knowledge, no evidence for an overlap in the genetic basis for MS and sporadic ALS.…”

Section: Discussionmentioning

confidence: 99%

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Mortality Statistics for Multiple Sclerosis and Amyotrophic Lateral Sclerosis in Sweden

2012

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Background: Multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are chronic neurologic diseases for which distinct explanations of the pathogenesis are lacking. Two large Swedish register studies have rather unexpectedly detected a correlation between MS and ALS. The aim of this study was to investigate if an association between ALS and MS could be demonstrated as has been shown earlier. Material and Methods: Data on mortality from ALS and MS, 1990–2010, were collected from the Swedish National Statistics Office. In all there were 5,696 deaths due to ALS and 3,941 deaths due to MS. Age- and sex-adjusted mortality rates were calculated. Results: There was no correlation between the mortality rates of ALS and MS in the 21 counties of Sweden for the period 1990–2010 (Spearman’s rho = –0.052; p = 0.822; n = 21). The national mean mortality rate for ALS throughout the period of 1990–2010 was 2.98 per 100,000 person-years (95% CI 2.87–3.08). For MS the national mean mortality rate was 2.04 per 100,000 person-years (95% CI 1.95–2.12). Conclusion: This study did not confirm the previously shown association between MS and ALS in Sweden.

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“…Шпанска студија (47) У последњих десетак година је описано постојање више фактора ризика за настанак ALSa. Наводе се: тежак физички рад (45,48), интензивно бављење спортом (професионални фудбалери и маратонци), пушење, траума, излагање тешким металима, олову и живи (49,50,51). Регистрована је повећана учесталост механичке трауме у болесника са ALS у поређењу са контролном групом (32,52,53,54).…”

Section: идиопатски (примарни) Als и обухвата: -спорадичну Als (Sals)unclassified

Prognostical factors and corelation with the survival of patients with amyotrophic lateral sclerosis

Kostić-Dedić¹

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Хвала мојим колегама са посла, клиничког одељења неурологије Клиничко-болничког центра "Звездара" а нарочито Проф. др. Вери Цвијановић.На крају, бескрајно сам захвална својим родитељима на непрестаној подршци и инспирацији. Mедиана времена преживљавања је 3 године (95%CI 2.86-3.14). Средње време трајања болести од почетка првих симптома је 4.35 ± 0.20 година. Средње животно доба на почетку болести је 57.74 ± 11.46 година док је средње животно доба приликом постављања дијагнозе 59.21 ± 11.26 година. Булбарни почетак је регистрован код 84 (25.8%) болесника, спинални почетак код 241 (74.1%). Код болесника са спиналним почетком је средње време трајања ALS 4.5 ± 0.2 година, било значајно дуже у односу на болеснике са булбарним почетком (3.7 ± 0.4 година, p=0.016). Иако је дуже средње време трајања болести код мушкараца (4.40 ± 0.3 година) у односу на жене (4.2 ± 0.3 година), пол нема утицаја на преживљавање у нашој кохорти (p>0.05). Cox-овом поцедуром је утврђено да су: млађе животно доба на почетку болести, дуже дијагностичко кашњење, виши ALSFRS скор приликом дијагностиковања и рана примена рилузола у статистички значајној корелацији са дужим преживљавањем. ЗАКЉУЧАК: Млађе животно доба на почетку болести и дуже дијагностичко кашњење су прогностички фактори дужег преживљавања болесника са ALS који су регистровани и у студијама других аутора. Већа вредност ALSFRS скора у моменту постављања дијагнозе и рана примена рилузола су додатни прогностички фактори дужег преживљавања. Старије животно доба на почетку болести и булбарни почетак болести су фактори лошије прогнозе у нашој кохорти болесника. OBJECTIVE:In order to define the prognostic factor for survival, at the first visit, we investigated our ALS database of patients residents in Belgrade, the last 17 years. MATERIAL AND METHODS:In the period 1992.-2009. 325 patients with the diagnosis of definite or probable ALS were discovered in the Belgrade district. The survival were assessed with the Kaplan-Meier method. The prognostic value of each factor was estimated using Cox proportional hazard analyses. RESULTS:As of December 2009. 267 ALS patients (82.2%) ALS have died. The median survival time was 3 years, (95%CI: 2.86-3.14). Mean survival time from symptoms onset was 4.35 ± 0.20 years. The mean age at onset was 57.74 ± 11.46 years and the mean age at diagnosis was 59.21 ± 11.26 years. Eighty four patients (25.8%) had a bulbar onset and 241 (74.1%) had spinal onset of the disease. Mean survival time from onset for patients with spinal onset was 4.5 ± 0.2 years and 3.7 ± 0.4 years for patients with bulbar onset (p=0.016). Mean survival time for men was 4.40 ± 0.3 years and 4.2 ± 0.3 years for women (p>0.05). In the Cox multivariable model, the factors independently related to a longer survival were younger age, longer diagnostic delay, higher ALSFRS score at first examination and early riluzole treatment. CONCLUSIONS:The identification of younger age, longer diagnostic delay as predictors of prolonged survival in ALS clinic population supports the findings of several...

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Motor Neuron Disease and Heavy Manual Labor: An Epidemiologic Survey of Värmland County, Sweden

Cited by 64 publications

References 19 publications

Distribution of Multiple Sclerosis in Sweden Based on Mortality and Disability Compensation Statistics

Distribution of Multiple Sclerosis in Sweden Based on Mortality and Disability Compensation Statistics

Mortality Statistics for Multiple Sclerosis and Amyotrophic Lateral Sclerosis in Sweden

Prognostical factors and corelation with the survival of patients with amyotrophic lateral sclerosis

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