Coupling of osteogenesis and angiogenesis in bone substitute healing – A brief overview

Götz, Werner; Reichert, Christoph; Canullo, Luigi; Jäger, Andreas; Heinemann, Friedhelm

doi:10.1016/j.aanat.2011.10.002

Cited by 55 publications

(43 citation statements)

References 11 publications

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“…Histologically, differences in the way of vascularization of bone substitutes can be observed: While in case of some substitutes, vessels come in close contact to the graft, a vascular perforation and even branching of new vessel into and inside the graft has been observed in others. These vessels may transport osteoblastic precursor cells into HA granules, as already discussed for the vessel ingrowth into the nanostructured bone substitute NanoBone® [60,78]. Positive effects of HA on angiogenesis are supported by in vitro studies showing a high biocompatibility of microvascular endothelial cell son HA nanocrystals [79].…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 50%

“…Angiogenetic transcription factors are upregulated and stabilized under hypoxic conditions, which may prevail during wound healing. The occurrence of hypoxia inducible factor (HIF-1α) during healing of a nanosized sHA is an indicator for these conditions [78]. However, other exogenous factors can influence the process of vasculogenesis, like the state of the pre-existing vascularization of the host tissue, aspects of the surgical procedure in augmentation, or mechanical interactions between the environment and the graft.…”

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

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Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad range of bone substitutes, synthetic hydroxyapatite has drawn much attention, as they are considered to be biocompatible, non-immunogenic, osteoconductive and osteoinductive. Scope of this review is to summarize existing knowledge concerning the molecular, cellular and pharmaceutical aspects of synthetic bone substitutes for oral and maxillofacial grafting.

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Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 50%

Section: Characterization and Preparation Of Synthetic Hamentioning

confidence: 99%

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Götz¹,

Papageorgiou²

2017

CPB

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“…Angiogenesis refers to the process by which new blood vessels sprout from the existing vasculature through the recruitment of endothelial cells (ECs), while vasculogenesis refers to the de novo formation of blood vessels from endothelial progenitors circulating bone marrow-derived endothelial progenitor cells (EPCs) [4, 5]. Recently, a number of breakthrough studies have pointed out that the processes of angiogenesis and osteogenesis are coupled temporally and spatially through the communication among vascular ECs, bone-building osteoblasts (OBs), and bone-resorbing osteoclasts (OCs) during bone development and remodeling [6-8]. The coupling relationship between angiogenesis and osteogenesis was reported in early studies by Clemens et al, who demonstrated that HIF-1 was a key molecule that couples angiogenesis to bone formation [9].…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, the involvement of EPCs in the early bone resorption activity is an important event for promoting skeletal development [8, 14]. OCs are specialized multinucleated cells derived from hematopoietic stem cells or monocytes/macrophage progenitor cells [15].…”

Section: Introductionmentioning

confidence: 99%

LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells

Quan

Liang

et al. 2018

Cell Physiol Biochem

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Background/Aims: In the process of bone development and remodeling, the vasculature is regarded as the communicative network between the bone and neighboring tissues. Recently, it has been reported that the processes of angiogenesis and osteogenesis are coupled temporally and spatially. However, few studies reported the relationship and relevant mechanism between osteoclastogenesis and vasculogenesis. Methods: Arraystar Mouse lncRNA microarray V3.0 was firstly used to analyze the differentially expressed lncRNA genes in osteoclast different stages during osteoclastogenesis. Cell counting kit 8 (CCK-8) analysis, quantitative real-time polymerase chain reaction (qRT-PCR) analysis, migration and tube formation assays were used to detect impact of osteoclast different stages on the proliferation, differentiation, migration and tube formation of endothelial progenitor cells (EPCs), respectively. Finally, transfection of AK131850 shRNA, miR-93-5p mimic and miR-93-5p inhibitor, qRT-PCR, western blotting, enzyme-linked immunosorbent assay (ELISA), fluorescence in situ hybridization (FISH) and luciferase reporter assay were carried out to dissect molecular mechanisms. Results: In this study, we found that newborn OCs (N-OC) and mature OCs (M-OC) during osteoclastogenesis significantly promoted proliferation, differentiation, migration and tube formation of endothelial progenitor cells (EPCs). Through lncRNA microarray and GO&pathway analysis, we found that AK131850 and co-expressed gene, vascular endothelial growth factor a (VEGFa), were significantly up-regulated in N-OC and M-OC. After inhibition of AK131850 the promoting effect of N-OC and M-OC on EPCs was reversed. Furthermore, we found that AK131850 directly competed miR-93-5p in N-OC and M-OC through sponge, thereby increasing VEGFa transcription, expression and secretion through derepressing of miR-93-5p on VEGFa. Conclusion: Our results provided the first finding that lncRNA-AK131850 sponged miR-93-5p in N-OC and M-OC during osteoclastogenesis to enhance the secretion of VEGFa, thus promoting vasculogenesis of EPCs.

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“…In the field of periodontal tissue regeneration, the use of synthetic materials, mostly hydroxyapatites, is growing every day because of their mechanical properties very similar to human bone characteristics. So these "Miming bone materials" were studied for their ability to trigger the Guided Tissues Regeneration (GTR) mechanisms (15)(16)(17). The present study was aimed to evaluate the capability of new bio-mimetic hydroxyapatite biomaterial to treat the complex periodontal intrabony defects.…”

Section: Discussionmentioning

confidence: 99%

Pediatric patients tolerance: a comparative study about using of Er:YAG laser and self-adhesive flowable composite for treatment of primary decayed teeth

Vozza¹

2016

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SummaryAim. Hydroxyapatite (PA) has a chemical composition and physical structure very similar to natural bone and therefore it has been considered to be the ideal biomaterial able to ensure a biomimetic scaffold to use in bone tissue engineering. The aim of this study is to clinically test hydroxyapatite used as osteoconductive biomaterial in the treatment of periodontal bone defects. Clinical and radiological evaluations were conducted at 6, 12 and 18 months after the surgery. Materials and methods. Forty patients with 2-and 3-wall intrabony pockets were enrolled in this study. PPD, CAL, radiographic depth (RD) and angular defects were preoperatively measured. After surgery, patients were re-evaluated every 6 months for 18 months. Statistical analyses were also performed to investigate any differences between preoperative and postoperative measurements. Results. Paired t-test samples conducted on the data obtained at baseline and 18 months after, showed significant (p<0.01) differences in each measurement performed. The role of preoperative RD was demonstrated to be a significant key factor (p<0.01). A relevant correlation between preoperative PPD and CAL gain was also found. Conclusions.Within the limitations of this study, the absence of anatomical variables, except the morphology of the bone defect, emphasizes the importance of the proper surgical approach and the graft material used.

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Coupling of osteogenesis and angiogenesis in bone substitute healing – A brief overview

Cited by 55 publications

References 11 publications

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

Molecular, Cellular and Pharmaceutical Aspects of Synthetic Hydroxyapatite Bone Substitutes for Oral and Maxillofacial Grafting

LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells

Pediatric patients tolerance: a comparative study about using of Er:YAG laser and self-adhesive flowable composite for treatment of primary decayed teeth

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