LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells

Quan, Hongyu; Liang, Mengmeng; Li, Nan; Dou, Ce; Liu, Chuan; Bai, Yun; Luo, Wei; Li, Jianmei; Kang, Fei; Cao, Zhen; Yang, Xiaochao; Jiang, Hong

doi:10.1159/000488474

Cited by 37 publications

(21 citation statements)

References 55 publications

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“…Thus, lncRNA-Jak3 may be a potential target candidate for MSU-induced osteoclast activation, and its role in physiological osteoclast differentiation should also be further investigated. Recently, lncRNA AK131850 was also described to be involved in the different stages of osteoclastogenesis 113 . Surprisingly, this lncRNA is a natural antisense transcript of VEGF and it can modulate endothelial progenitor cells 113 .…”

Section: Introductionmentioning

confidence: 99%

“…Recently, lncRNA AK131850 was also described to be involved in the different stages of osteoclastogenesis 113 . Surprisingly, this lncRNA is a natural antisense transcript of VEGF and it can modulate endothelial progenitor cells 113 . AK131850 acts as an endogenous sponge for miR-93-5p, which alleviates the repression on VEGF expression and, consequently, promotes proliferation, differentiation, migration, and tube formation of endothelial progenitor cells 113 .…”

Section: Introductionmentioning

confidence: 99%

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Long noncoding RNAs: a missing link in osteoporosis

et al. 2019

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Osteoporosis is a systemic disease that results in loss of bone density and increased fracture risk, particularly in the vertebrae and the hip. This condition and associated morbidity and mortality increase with population ageing. Long noncoding (lnc) RNAs are transcripts longer than 200 nucleotides that are not translated into proteins, but play important regulatory roles in transcriptional and post-transcriptional regulation. Their contribution to disease onset and development is increasingly recognized. Herein, we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic tools. Firstly, current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication, fragility fractures, is reviewed. We analyze evidence of their roles in osteogenesis, osteoclastogenesis, and bone fracture healing events from human and animal model studies. Secondly, the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for diagnosis. Finally, we conclude debating the possibilities, persisting difficulties, and future prospects of using lncRNAs in the treatment of osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long noncoding RNAs: a missing link in osteoporosis

et al. 2019

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“…Most studies regarding the relationship between lncRNA and miRNA concentrated on the effects on osteogenic differentiation, and there have been few related studies on osteoclasts. One study showed that, during osteoclastogenesis, lncRNA-AK131850 can act as a sponge for miR-93-5p in newborn and mature osteoclasts, increasing vascular endothelial growth factor A (VEGF-A) transcription, expression, and secretion by reducing miR-93-5, thereby promoting vasculogenesis of endothelial progenitor cells [109]. Although this finding was not directly related to osteoporosis, it was closely related to osteoclasts, so it may be useful in developing treatments for osteoporosis.…”

Section: Interactions Between Lncrnas and Mirnasmentioning

confidence: 99%

The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

et al. 2020

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Osteoporosis is a common metabolic bone disease, influenced by genetic and environmental factors, that increases bone fragility and fracture risk and, therefore, has a serious adverse effect on the quality of life of patients. However, epigenetic mechanisms involved in the development of osteoporosis remain unclear. There is accumulating evidence that epigenetic modifications may represent mechanisms underlying the links of genetic and environmental factors with increased risk of osteoporosis and bone fracture. Some RNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have been shown to be epigenetic regulators with significant involvement in the control of gene expression, affecting multiple biological processes, including bone metabolism. This review summarizes the results of recent studies on the mechanisms of miRNA-, lncRNA-, and circRNA-mediated osteoporosis associated with osteoblasts and osteoclasts. Deeper insights into the roles of these three classes of RNA in osteoporosis could provide unique opportunities for developing novel diagnostic and therapeutic approaches to this disease.

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“…Endothelial progenitor cells (EPCs) are precursor cells of vascular endothelial cells, which have the ability to proliferate, migrate, and differentiate into cells arranged along the lumen of blood vessels [14]. It has been found in previous studies that EPCs can enhance the osteogenic activity of pre-osteoblasts [15] and play an important role in bone formation and repair [16,17]. Adipose-derived mesenchymal stem cells (ASCs) are extracted from adipose tissue with high proliferative capability and multi-differential potential [18,19].…”

Section: Introductionmentioning

confidence: 99%

The co-culture of ASCs and EPCs promotes vascularized bone regeneration in critical-sized bone defects of cranial bone in rats

Lin

et al. 2020

Stem Cell Res Ther

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Background: The repair of critical-sized bone defect represents a challenging problem in bone tissue engineering. To address the most important problem in bone defect repair, namely insufficient blood supply, this study aimed to find a method that can promote the formation of vascularized bone tissue. Method: The phenotypes of ASCs and EPCs were identified respectively, and ASCs/EPCs were co-cultured in vitro to detect the expression of osteogenic and angiogenic genes. Furthermore, the co-culture system combined with scaffold material was used to repair the critical-sized bone defects of the cranial bone in rats. Results: The co-culture of ASCs/EPCs could increase osteogenesis and angiogenesis-related gene expression in vitro. The results of in vivo animal experiments demonstrated that the ASC/EPC group could promote bone regeneration and vascularization in the meantime and then significantly accelerate the repair of critical-sized bone defects. Conclusion: It is feasible to replace traditional single seed cells with ASC/EPC co-culture system for vascularized bone regeneration. This system could ultimately enable clinicians to better repair the defect of craniofacial bone and avoid donor site morbidity.

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LncRNA-AK131850 Sponges MiR-93-5p in Newborn and Mature Osteoclasts to Enhance the Secretion of Vascular Endothelial Growth Factor a Promoting Vasculogenesis of Endothelial Progenitor Cells

Cited by 37 publications

References 55 publications

Long noncoding RNAs: a missing link in osteoporosis

Long noncoding RNAs: a missing link in osteoporosis

The roles of miRNA, lncRNA and circRNA in the development of osteoporosis

The co-culture of ASCs and EPCs promotes vascularized bone regeneration in critical-sized bone defects of cranial bone in rats

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