Coupled Nerve: A Technique to Increase the Nerve Conduction Velocity in Demyelinating Polyneuropathic Patients

Das, H. K.; Sahu, Partha Pratim

doi:10.1016/j.proeng.2013.09.099

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…γ = demyelination factor which is defined as the ratio of change in myelin thickness due to demyelination to the actual amount of myelin thickness of the nerve. The effect of demyelination factor upon resistance, capacitance and conductance in the circuit has already been discussed in our previous work 29 30 . The total resistance in the circuit is mainly divided into internal resistance (R i ) and external resistance (R o ).…”

Section: Introductionmentioning

confidence: 85%

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Quantifying Demyelination in NK venom treated nerve using its electric circuit model

Das

Doley

et al. 2016

Sci Rep

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Reduction of myelin in peripheral nerve causes critical demyelinating diseases such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, etc. Clinical monitoring of these diseases requires rapid and non-invasive quantification of demyelination. Here we have developed formulation of nerve conduction velocity (NCV) in terms of demyelination considering electric circuit model of a nerve having bundle of axons for its quantification from NCV measurements. This approach has been validated and demonstrated with toad nerve model treated with crude Naja kaouthia (NK) venom and also shows the effect of Phospholipase A2 and three finger neurotoxin from NK-venom on peripheral nerve. This opens future scope for non-invasive clinical measurement of demyelination.

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Section: Introductionmentioning

confidence: 85%

“…1(d) . The values of ionic conductance, Nernst potential and threshold voltage of sodium, slow potassium, fast potassium and leakage ions of frog are obtained from previous works 29 30 . The variation of NCV is determined by using equation (1) , decreases with increase of demyelinating factor ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Quantifying Demyelination in NK venom treated nerve using its electric circuit model

Das

Doley

et al. 2016

Sci Rep

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Electro-Physiology of Coupling Model and Its Impact on Naja Kaouthia Venom Treated Sciatic Nerves of Toad

Das

Sahu

2018

IEEE Trans. Neural Syst. Rehabil. Eng.

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Demyelination in peripheral nerves causes dysfunction of slowing down and stoppage of nerve impulses causing many neurological diseases, such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, etc. This paper aims to develop a recovery model having interaction of a demyelinated nerve with a normal myelinated nerve. We validated the model by coupling between peripheral nerve of toad (demyelinated with Naja kaouthia venom) and a normal nerve of toad. An increase in both nerve conduction velocity as well as compound action potential amplitude is observed in the repetition of the experiments indicating gradual recovery of the patients. The significance behind this work is to suppress the malfunctioning of the demyelinated nerve by the normal electro-physiological activity of the normal nerve for speedy recovery using coupling model. The recovery model will be used in the treatment of neurological disorders with the influence of normal neuro physiological properties of a normal adjacent nerve.

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Coupled Nerve: A Technique to Increase the Nerve Conduction Velocity in Demyelinating Polyneuropathic Patients

Cited by 2 publications

References 13 publications

Quantifying Demyelination in NK venom treated nerve using its electric circuit model

Quantifying Demyelination in NK venom treated nerve using its electric circuit model

Electro-Physiology of Coupling Model and Its Impact on Naja Kaouthia Venom Treated Sciatic Nerves of Toad

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