Electro-Physiology of Coupling Model and Its Impact on Naja Kaouthia Venom Treated Sciatic Nerves of Toad

Abstract

Demyelination in peripheral nerves causes dysfunction of slowing down and stoppage of nerve impulses causing many neurological diseases, such as chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, etc. This paper aims to develop a recovery model having interaction of a demyelinated nerve with a normal myelinated nerve. We validated the model by coupling between peripheral nerve of toad (demyelinated with Naja kaouthia venom) and a normal nerve of toad. An increase in both nerve conduction velocity as well as compound action potential amplitude is observed in the repetition of the experiments indicating gradual recovery of the patients. The significance behind this work is to suppress the malfunctioning of the demyelinated nerve by the normal electro-physiological activity of the normal nerve for speedy recovery using coupling model. The recovery model will be used in the treatment of neurological disorders with the influence of normal neuro physiological properties of a normal adjacent nerve.

Conductive Hydrogel for a Photothermal-Responsive Stretchable Artificial Nerve and Coalescing with a Damaged Peripheral Nerve

“…The isolated sciatic nerve and sural muscle of the hoptoad were chosen to verify whether the CPH had a good conductivity and could be used as an implantable nerve substitute ex vivo . For the study of nerve signal conduction, the sciatic nerve isolated from the hoptoad was a classic model in vitro . − For the hoptoad’s sciatic nerve, when the stimulating voltage is beyond the threshold of the resting potential, a contraction of gastrocnemius would be induced by the action potential. The scheme of the experimental setup is shown in Figure A.…”