Coumarins Isolated from the Roots of<i>Seseli resinosum</i>. in Turkey

Tosun, Alev; Baba, M.; Bahadır, Özlem; Okuyama, Toru

doi:10.1080/13880200600883064

Cited by 18 publications

(14 citation statements)

References 33 publications

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“…In Turkish folk medicine, the fruit of Seseli tortuosum is used as emmenagogue and antiflatulent (Baytop, 1999). This EO have been investigated for its various biological properties including anti-inflammatory, antinociceptive (Küpeli et al, 2006b;Tosun et al, 2006) and antifungal activities (Gonçalves et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells

Beeby

Magalhães

Poças

et al. 2020

Journal of Ethnopharmacology

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Despite advances in modern therapeutic strategies, cancer remains the second leading cause of death worldwide. Therefore, there is a constant need to develop more efficient anticancer targeting strategies. The anticancer therapeutic proprieties of medicinal plants and their bioactive compounds have been reported for several years, making natural extracts and/or compounds derived from these a promising source of novel anticancer agents. Sand dune plants are subjected to severe environmental stresses, leading to the development of adaptations, including the production of secondary metabolites with a wide range of bioactivities, such as: anti-inflammatory, analgesic, antiseptic, hypoglycaemic, hypotensive, antinociceptive, antioxidant and anticancer. Aim of the study: The anticancer potential of sand dune plants remains under-investigated, so this research describes the characterisation of the composition of bioactive EOs from sand-dune plants of Peniche (Portugal), and assessment of their activity in vitro and potential mechanism of action. Materials and methods: EOs were extracted from six sand-dune species of plants from Peniche sand dunes: Crithmum maritimum L., Seseli tortuosum L., Artemisia campestris subsp. maritima (DC.) Arcang., Juniperus phoenicea var. turbinata (Guss.) Parl., Otanthus maritimus (L.) Hoffmanns. & Link, and Eryngium maritimum L.. EOs composition was fully characterised chemically using Gas Chromatography-Mass Spectrometry (GC-MS). The assessment of anticancer activity and mechanism of action was performed in vitro using breast and colorectal cancer 2D and 3D spheroid cell line models, through cell proliferation assay, western blotting analysis, and cell cycle analysis. Results: EOs from the majority of the species tested (S. tortuosum, A. campestris subsp. maritima, O. maritimus, and E. maritimum) were mainly composed by hydrocarbon compounds (sequisterpenes and monoterpenes), showing antiproliferative activity in both 2D and 3D models. EO extracted from S. tortuosum and O. maritimus were identified as having the lowest IC 50 values for both cell lines when compared with the other species tested. Furthermore, this antiproliferative activity was associated with increased p21 expression and induction of apoptosis. Conclusions: The present study suggests that EOs extracted from S. tortuosum and O. maritimus present promising cytotoxic properties. Further evaluation of the extracts and their key components as potential anticancer agents should therefore be explored.

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Section: Introductionmentioning

confidence: 99%

Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells

Beeby

Magalhães

Poças

et al. 2020

Journal of Ethnopharmacology

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“…In Turkey, there are limited studies on Seseli species based on the coumarins Tosun, 2006;Tosun et al, 2006a, Zhang et al, 2010Shehzad et al, 2013) and the essential oils (Baser et al, 2000;Kaya et al, 2003;2006b;2006c). Previously, antimicrobial (Tosun et al, 2004), anti-inflammatory and antinociceptive (Küpeli et al, 2005;Tosun et al, 2009;Chun et al, 2016) effects have been performed on Turkish Seseli species.…”

Section: Introductionmentioning

confidence: 99%

EVALUATION of ANTIOXIDANT POTENCY on SESELI L. SPECIES (APIACEAE)

Önder¹,

Çınar²,

Sarıaltın³

et al. 2019

tjps

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“…Seseli species, perennial or biennial herbaceous plants, usually grow at high altitudes, especially in rocky areas and cliffs in Turkey [2][3][4][5], are composed of 12 species, four of which are endemic to Turkey. There is no record regarding the chemical constituents of these native plants except for our previous studies [6][7][8][9][10][11][12]. The genus Seseli is rich in coumarins, and some of them are well known for medicinal properties [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

HPLC analysis of coumarins in Turkish Seseli species (Umbelliferae)

2007

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The n-hexane extracts of aerial and underground parts of three Seseli species, S. gummiferum subsp. corymbosum, S. resinosum, and S. hartvigii growing in Turkey were investigated concerning the presence of coumarins by normal-phase HPLC (high-performance liquid chromatography). In this respect, two coumarins, osthol (1) and corymbocoumarin (2) [(-)-(3¢S, 4¢S)-3¢-acetoxy-4¢-isovaleryloxy-3¢, 4¢-dihydroseselin] isolated from aerial parts of S. gummiferum subsp. corymbosum, were used as standard samples. The amount of these compounds were discussed and evaluated in this study.

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Coumarins Isolated from the Roots ofSeseli resinosum. in Turkey

Cited by 18 publications

References 33 publications

Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells

Secondary metabolites (essential oils) from sand-dune plants induce cytotoxic effects in cancer cells

EVALUATION of ANTIOXIDANT POTENCY on SESELI L. SPECIES (APIACEAE)

HPLC analysis of coumarins in Turkish Seseli species (Umbelliferae)

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