Coumarin-Modified CQDs for Biomedical Applications—Two-Step Synthesis and Characterization

Janus, Łukasz; Radwan-Pragłowska, Julia; Piątkowski, Marek; Bogdał, Dariusz

doi:10.3390/ijms21218073

Cited by 13 publications

(7 citation statements)

References 39 publications

(99 reference statements)

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“…The prepared CDs were used for sensing Cu 2+ ions 89 . Lignin-derived CDs functionalized with coumarin derivatives were reported to have real-time cell visualization ability 103 . Polyacrylamide-derived CDs were reported and involved in the electrochemical sensing of glucose 28 .…”

Section: Design Of Carbon Dots From Polymer Moleculesmentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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Fluorescent Carbon dots (CDs) derived from biologically active sources have shown enhanced activities compared to their precursors. With their prominent potentiality, these small-sized (<10nm) nanomaterials could be easily synthesized from organic sources either by bottom-up or green approach. Their sources could influence the functional groups present on the CDs surfaces. A crude source of organic molecules has been used to develop fluorescent CDs. In addition, pure organic molecules were also valuable in developing practical CDs. Physiologically responsive interaction of CDs with various cellular receptors is possible due to the robust functionalization on their surface. In this review, we studied various literatures from the past ten years that reported the potential application of carbon dots as alternatives in cancer chemotherapy. The selective cytotoxic nature of some of the CDs towards cancer cell lines suggests the role of surface functional groups towards selective interaction, which results in over-expressed proteins characteristic of cancer cell lines. It could be inferred that cheaply sourced CDs could selectively bind to overexpressed proteins in cancer cells with the ultimate effect of cell death induced by apoptosis. In most cases, CDs-induced apoptosis directly or indirectly follows the mitochondrial pathway. Therefore, these nanosized CDs could serve as alternatives to the current kinds of cancer treatments that are expensive and have numerous side effects.

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Section: Design Of Carbon Dots From Polymer Moleculesmentioning

confidence: 99%

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ahmad¹,

Aung²,

Widati³

et al. 2023

Nanotheranostics

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show abstract

“…Coumarin derivatives are used to discover a variety of new antibiotics, anticoagulants, bio-enzymes, chemotherapeutics, and bioluminescence. Coumarin derivatives have a good complexing ability with metal ions [32][33][34][35][36]. The formation of metal coumarin complexes plays an ideal role in biological activities.…”

Section: Introductionmentioning

confidence: 99%

Ecofriendly one-pot fabrication of 7-methoxy coumarin encapsulated zeolitic imidazole nanocomposite for pH-responsive wound healing application and its biosafety evaluations

Raju¹,

Rajkumar²,

Muthu³

2023

Preprint

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Biocompatible 7-methoxy coumarin encapsulated 7-MC@ZIF-L nanocomposite was fabricated to develop efficient wound healing. The stimuli-responsive drug release mechanism was examined at pH 5 and 7.4. The release of coumarin was increased within three hours by burst release under acidic conditions. The 7-MC@ZIF-L nanocomposite shows significant bacterial growth control against human infectious pathogens S. aureus, E. coli, P. aeruginosa, and S. epidermis. Moreover, the MTT and AO/EB assays revealed that nanocomposite had high cell viability towards L929 fibroblast cells. The present study enlightens a novel one-pot fabrication of 7-MC@ZIF-L nanocomposite as a drug delivery system and its stimuli-responsive drug release ability. The current methodology is an effective approach than any existing post-synthesis methods. The synthesized 7-MC@ZIF-L nanocomposite demonstrates ultrahigh thermal and chemical stability. The anti-biofilm results confirmed that the nanocomposite effectively inhibits biofilm formation and damages the biofilm architectural matrix based on the dose-dependent manner. In vitro wound scratch assay revealed that the sustainable and slow release of 7-methoxy coumarin and zinc ions promotes the cell proliferation rate. Bio-compatibility study results confirmed that the 7-MC@ZIF-L nanocomposite is safer and non-toxic for human use. In vivo artemia, salina lethality assay concluded that the nanocomposite is highly suitable for wound healing and other biomedical applications. The overall results signify that the 7-MC-ZIF-L nanocomposite is an efficient material for stimuli-responsive wound healing treatment in the future for wound care therapy.

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“…On the other hand, lignin, which makes up 15-35% of lignocellulose, is often removed and transferred to be burned as a fuel when cellulose is extracted from woody feedstock [8][9][10]. However, it has already been shown that monolignols and low-molecular weight lignin can be applied to the development of various functional materials such as UV absorbents, luminescent materials, anti-virus agents, and antioxidants [11][12][13][14]. Ligninderived phenols can also be pro-oxidants for degrading pollutants [15].…”

Section: Introductionmentioning

confidence: 99%

Degradation of Lignin by Infrared Free Electron Laser

et al. 2022

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Lignin monomers have attracted attention as functional materials for various industrial uses. However, it is challenging to obtain these monomers by degrading polymerized lignin due to the rigid ether linkage between the aromatic rings. Here, we propose a novel approach based on molecular vibrational excitation using infrared free electron laser (IR-FEL) for the degradation of lignin. The IR-FEL is an accelerator-based pico-second pulse laser, and commercially available powdered lignin was irradiated by the IR-FEL under atmospheric conditions. Synchrotron-radiation infrared microspectroscopy analysis showed that the absorption intensities at 1050 cm−1, 1140 cm−1, and 3400 cm−1 were largely decreased alongside decolorization. Electrospray ionization mass chromatography analysis showed that coumaryl alcohol was more abundant and a mass peak corresponding to hydrated coniferyl alcohol was detected after irradiation at 2.9 μm (νO-H) compared to the original lignin. Interestingly, a mass peak corresponding to vanillic acid appeared after irradiation at 7.1 μm (νC=C and νC-C), which was supported by our two-dimensional nuclear magnetic resonance spectroscopy analysis. Therefore, it seems that partial depolymerization of lignin can be induced by IR-FEL irradiation in a wavelength-dependent manner.

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Coumarin-Modified CQDs for Biomedical Applications—Two-Step Synthesis and Characterization

Cited by 13 publications

References 39 publications

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

A Perspective on Using Organic Molecules Composing Carbon Dots for Cancer Treatment

Ecofriendly one-pot fabrication of 7-methoxy coumarin encapsulated zeolitic imidazole nanocomposite for pH-responsive wound healing application and its biosafety evaluations

Degradation of Lignin by Infrared Free Electron Laser

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