Degradation of Lignin by Infrared Free Electron Laser

Kawasaki, Takayasu; Zen, Heishun; Sakai, Takeshi; Sumitomo, Yoske; Nogami, Keiji; Hayakawa, Katsumi; Yaji, Toyonari; Ohta, Toshiaki; Nagata, Takashi; Hayakawa, Yasushi

doi:10.3390/polym14122401

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Presently, IR-FELs are open at many synchrotron-radiation facilities all over the world since the optical emission was first observed at a laboratory level more than 50 years ago [ 31 ]. Various original experimental studies using IR-FELs are reported as follows: ablation of biological tissues [ 32 , 33 , 34 ], alteration of biological functions [ 35 , 36 ], degradation of protein–metal complexes [ 37 , 38 ], optical and spectroscopic imaging [ 39 , 40 , 41 ], structural dynamics of biomolecules [ 42 , 43 ], chemical reactions in the gas phase [ 44 , 45 , 46 ], decomposition of biopolymers [ 47 , 48 , 49 ], nonlinear-optical physics [ 50 ], and observation of terahertz radiation [ 51 ].…”

Section: Introductionmentioning

confidence: 99%

Disassembly of Amyloid Fibril with Infrared Free Electron Laser

Kawasaki

Tsukiyama

Nguyen

2023

IJMS

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Amyloid fibril causes serious amyloidosis such as neurodegenerative diseases. The structure is composed of rigid β-sheet stacking conformation which makes it hard to disassemble the fibril state without denaturants. Infrared free electron laser (IR-FEL) is an intense picosecond pulsed laser that is oscillated through a linear accelerator, and the oscillation wavelengths are tunable from 3 μm to 100 μm. Many biological and organic compounds can be structurally altered by the mode-selective vibrational excitations due to the wavelength variability and the high-power oscillation energy (10–50 mJ/cm2). We have found that several different kinds of amyloid fibrils in amino acid sequences were commonly disassembled by the irradiation tuned to amide I (6.1–6.2 μm) where the abundance of β-sheet decreased while that of α-helix increased by the vibrational excitation of amide bonds. In this review, we would like to introduce the IR-FEL oscillation system briefly and describe combination studies of experiments and molecular dynamics simulations on disassembling amyloid fibrils of a short peptide (GNNQQNY) from yeast prion and 11-residue peptide (NFLNCYVSGFH) from β2-microglobulin as representative models. Finally, possible applications of IR-FEL for amyloid research can be proposed as a future outlook.

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Section: Introductionmentioning

confidence: 99%

Disassembly of Amyloid Fibril with Infrared Free Electron Laser

Kawasaki

Tsukiyama

Nguyen

2023

IJMS

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Sustainable carbon sources for green laser-induced graphene: A perspective on fundamental principles, applications, and challenges

Claro

Pinheiro

Silvestre

et al. 2022

Applied Physics Reviews

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Since the discovery of laser-induced graphene (LIG), significant advances have been made to obtain green LIG (gLIG) from abundant, eco-friendly, natural, and organic renewable bio-based carbon sources. Recently, some sustainable and cost-effective electronic devices have been designed with gLIG, resulting in diverse solutions to the environmental impact caused by electronic waste (e-waste). However, there are still several challenges that must be addressed regarding the widespread market implementation of gLIG-based products, from synthesis to practical applications. In this review, we focus on sustainable precursor sources, their conversion mechanisms, physical and chemical properties and applications, along with the challenges related to its implementation, showing the future opportunities and perspectives related to this promising new material. Various systems based on gLIG for energy storage, electrocatalysis, water treatment, and sensors have been reported in the literature. Additionally, gLIG has been proposed for ink formulation or incorporation into polymer matrices, to further expand its use to non-carbon-based substrates or applications for which pristine LIG cannot be directly used. In this way, it is possible to apply gLIG on diverse substrates, aiming at emerging wearable and edible electronics. Thus, this review will bring an overview of gLIG developments, in accordance with the European Green Deal, the United Nations Sustainable Development Goals and the new era of internet-of-things, which demands cost-effective electronic components based on the principles of energy efficiency and sustainable production methods.

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Prominent Anti-UVC Activity of Lignin Degradation Products

Sakagami

Amano

Uota

et al. 2022

In Vivo

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Background/Aim: The rapid spread of COVID-19 resulted in the revision of the value of ultraviolet C (UVC) sterilization in working spaces. This study aimed at re-evaluating the anti-UVC activity of four groups of natural products against human melanoma COLO679 and human normal dermal fibroblast (HDFa) cells, based on chemotherapeutic index. Materials and Methods: Various cell lines were exposed to UVC for 3 min in the presence of increasing concentrations of test compounds and viable cell numbers were determined with the 3-( 4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide assay. The anti-UVC activity was quantified by the ratio of the 50% cytotoxic concentration (determined without irradiation) to the 50% effective concentration (which abolished by 50% the UVCinduced loss of viability). Apoptosis was quantified as the subG 1 population proportion following cell-cycle analysis. Results: Among four groups of major natural products, six phenylpropanoids showed the highest anti-UVC activity, followed by the lignified products and alkaline products that contain lignin and its degradation products. On the other hand, tannins and flavonoids showed lower activity due to their higher cytotoxicity. UVC-sensitive COLO679 cells lack dectin-1 protein expression. Conclusion: These data suggest the prominent anti-UVC activity of lignin degradation products, and the possible involvement of dectin-1 expression in UVC-sensitivity.

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Degradation of Lignin by Infrared Free Electron Laser

Cited by 3 publications

References 39 publications

Disassembly of Amyloid Fibril with Infrared Free Electron Laser

Disassembly of Amyloid Fibril with Infrared Free Electron Laser

Sustainable carbon sources for green laser-induced graphene: A perspective on fundamental principles, applications, and challenges

Prominent Anti-UVC Activity of Lignin Degradation Products

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