2023
DOI: 10.21203/rs.3.rs-2862242/v1
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Ecofriendly one-pot fabrication of 7-methoxy coumarin encapsulated zeolitic imidazole nanocomposite for pH-responsive wound healing application and its biosafety evaluations

Abstract: Biocompatible 7-methoxy coumarin encapsulated 7-MC@ZIF-L nanocomposite was fabricated to develop efficient wound healing. The stimuli-responsive drug release mechanism was examined at pH 5 and 7.4. The release of coumarin was increased within three hours by burst release under acidic conditions. The 7-MC@ZIF-L nanocomposite shows significant bacterial growth control against human infectious pathogens S. aureus, E. coli, P. aeruginosa, and S. epidermis. Moreover, the MTT and AO/EB assays revealed that nanocompo… Show more

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