Could urinary nerve growth factor be a biomarker for overactive bladder? A meta-analysis

Wei, Sheng; Zhang, Hongwei; Ruth, Kirschner-Hermanns

doi:10.1002/nau.23210

Cited by 19 publications

(16 citation statements)

References 22 publications

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“…There is considerable interest in new biochemical and imaging biomarkers that might replace detrusor overactivity as an objective clinical end point; however, none has progressed to widespread adoption in clinical practice. The most widely tested urinary marker, nerve growth factor, has demonstrated problems with specificity and reproducibility 170 . The most widely investigated imaging marker, bladder wall thickness, also failed to demonstrate prognostic value when tested in a large trial of implementation 171 .…”

Section: Discussionmentioning

confidence: 99%

Urinary incontinence in women

Aoki

Brown

Brubaker

et al. 2017

Nat Rev Dis Primers

341

317

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Urinary incontinence symptoms are highly prevalent among women, have a substantial effect on health-related quality of life and are associated with considerable personal and societal expenditure. Two main types are described: stress urinary incontinence, in which urine leaks in association with physical exertion, and urgency urinary incontinence, in which urine leaks in association with a sudden compelling desire to void. Women who experience both symptoms are considered as having mixed urinary incontinence. Research has revealed overlapping potential causes of incontinence, including dysfunction of the detrusor muscle or muscles of the pelvic floor, dysfunction of the neural controls of storage and voiding, and perturbation of the local environment within the bladder. A full diagnostic evaluation of urinary incontinence requires a medical history, physical examination, urinalysis, assessment of quality of life and, when initial treatments fail, invasive urodynamics. Interventions can include non-surgical options (such as lifestyle modifications, pelvic floor muscle training and drugs) and surgical options to support the urethra or increase bladder capacity. Future directions in research may increasingly target primary prevention through understanding of environmental and genetic risks for incontinence.

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Section: Discussionmentioning

confidence: 99%

Urinary incontinence in women

Aoki

Brown

Brubaker

et al. 2017

Nat Rev Dis Primers

341

317

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“…Despite this, the finding of the current study can correlate to women developing de novo urgency or frequency after mesh placement that opened the paravesical space. A couple of studies had demonstrated increased NGF levels on patients with overactive bladder and bladder inflammation 17,18 .…”

Section: Discussionmentioning

confidence: 99%

Dissecting of the paravesical space associated with lower urinary tract dysfunction – a rat model

Lo¹,

Lin²,

Uy-Patrimonio³

et al. 2020

Sci Rep

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to determine the association of opening the paravesical space in relation to its occurrence of de novo SUI in an animal model. Thirty five female Sprague Dawley rats were divided into 5 groups of 7 rats each: Control group, Sham groups(F, H), and Study groups(MF, MH). Groups labeled with "F" had the paravesical space opened, "H" had tissue dissection with no opening of the space, and "M" had mesh implanted inside the vaginal wall. Urodynamic studies, immunohistochemical analysis, and western blot were done at day 40. The mean weight and age of 35 rats were 302.1 ± 25.1 grams and 12.8 ± 1.2 weeks old. No significant differences were noted among the control, Sham F, Sham H, Study MF, and Study MH on the voiding pressure and voided volume. The Sham F and Study MF (opened paravesical space) groups had significantly lower values on leak point pressures (LPP) (p = 0.026; p < 0.001) and shorter voiding intervals (p = 0.032; p = 0.005) when compared to other groups. Immunohistochemical analysis showed IL-1 and TNF-α to be intensely increased for the Study MF group (p = 0.003; p = <0.001). MMP-2 and CD 31 markers were also significantly higher in the Study MH and MF group. NGF expression was significantly increased in the Study MF and Sham F groups. Thus, opening of the paravesical space causes an increased inflammatory reaction, which leads to tissue destruction and lower urinary tract dysfunction, exemplified in the study with low leak point pressure and shortened voiding intervals.Stress urinary incontinence (SUI) has affected adult women with an incidence 4% to 35% 1 . Widely recognized risk factors associated with the development of SUI include aging, obesity, and smoking where as birth trauma and anatomical distortion due to pelvic organ prolapse are somewhat controversial 1 .Of particular concern nowadays is the occurrence of de novo SUI noted with increasing frequency after pelvic organ prolapse corrective surgeries. Wei et al. 2 reports an incidence of 43% after prolapse surgery and Lo et al. 3 demonstrates the occurrence of de novo SUI at 26.3% after prolapse surgery using mesh kits such as the Elevate TM system. In a separate study by Lo et al. 4 23% of patient developed post-operative de novo SUI after using the Uphold TM (Boston Scientific) Lite system. The similarity that these two separate studies shares is that, these mesh kits utilizes the anterior approach for bilateral sacrospinous ligament fixation. This procedure entails opening the paravesical space, in which Lo et al. 3,4 in his two studies has postulated that opening this space could lead lowering of the mean urethral closure pressure (MUCP), hence SUI. Moreover, other predictive factors also contribute to the occurrence of de novo SUI. These would include age >66 years, diabetes mellitus, maximum urethral closure pressure (MUCP) <60 cm H 2 O and functional urethral length (FUL) <2 cm 5 .At present, all available data with regards to the occurrence of de novo SUI are limited to postulated theories. There have been no reported studies attempting to...

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“…Because of its mitigating effects, menthol was a particularly interesting compound in the context of IC. Chronic inflammation is typical in the pathogenesis of IC 31 , and higher levels of pro-inflammatory cytokines, such as macrophage-derived chemokines 32 or urinary nerve growth factors, are reported to be associated with the disease 33 , 34 .…”

Section: Discussionmentioning

confidence: 99%

Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis

Shahid

Lee

Yeon

et al. 2018

Sci Rep

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Chronic inflammation is a potential systemic risk factor for many bladder dysfunctions, including interstitial cystitis (IC). However, the underlying mechanism through which a healthy bladder protects itself from inflammatory triggers remains unknown. In this study, we identified odor compounds in urine obtained from IC patients and healthy controls. Using comprehensive solid-phase microextraction-gas chromatography-time-of-flight-mass spectrometry (SPME-GC-TOF-MS) profiling and bioinformatics, we found that levels of urinary volatile metabolites, such as menthol, were significantly reduced in IC patients, compared to healthy controls. In an attempt to understand the mechanistic meaning of our volatile metabolites data and the role of menthol in the immune system, we performed two independent experiments: (a) cytokine profiling, and (b) DNA microarray. Our findings suggest that lipopolysaccharide (LPS)-stimulated inflammatory events, such as the production and secretion of inflammatory cytokines (e.g., TNF-α, IL-6, and IL-1β) and the activation of NF-κB and associated proteins within a large signaling network (e.g., Akt, TLR1, TNFAIP3, and NF-κB), are suppressed by the presence of menthol. These findings broaden our knowledge on the role of urinary menthol in suppressing inflammatory events and provide potential new strategies for alleviating both the odor and inflammation associated with IC.

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Could urinary nerve growth factor be a biomarker for overactive bladder? A meta-analysis

Cited by 19 publications

References 22 publications

Urinary incontinence in women

Urinary incontinence in women

Dissecting of the paravesical space associated with lower urinary tract dysfunction – a rat model

Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis

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