Cough in pulmonary tuberculosis: Existing knowledge and general insights

Turner, Richard

doi:10.1016/j.pupt.2019.01.008

Cited by 18 publications

(8 citation statements)

References 77 publications

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“… 4 , 6 Symptoms such as cough fever and weight loss are mediated by a combination of factors including by cytokines generated by inflammatory cells and tissue damage at the site of disease, metabolic dysregulation and potentially by components of the Mtb cell wall itself. 42 , 43 , 44 Hence, symptoms may not be evident until a certain threshold level of pathology is reached which may vary between individuals and may be affected by the infecting strain of Mtb.…”

Section: The Spectrum Of Tb Diseasementioning

confidence: 99%

Mind the gap – Managing tuberculosis across the disease spectrum

et al. 2022

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Section: The Spectrum Of Tb Diseasementioning

confidence: 99%

Mind the gap – Managing tuberculosis across the disease spectrum

et al. 2022

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“…A number of Asian countries are still endemic areas of pulmonary tuberculosis (TB) with the additional burden of drug-resistant cases [ 61 ]. In pulmonary TB, coughing is a key manifestation suggesting current infection and means of transmission [ 62 ]. Therefore, for those from populations of high TB prevalence, active case finding is recommended for patients with cough to improve clinical outcomes and reduce transmission [ 63 ].…”

Section: Under-recognized Regional Issues In the Asia-pacific Regionmentioning

confidence: 99%

Epidemiology of adult chronic cough: disease burden, regional issues, and recent findings

Lee

Kang

Yoo

et al. 2021

Asia Pacific Allergy

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Chronic cough is a common medical condition that has a significant impact on patients’ quality of life. Although it was previously considered a symptom of other disorders, it is now regarded as a pathologic state that is characterized by a deviation from the intrinsic protective functions of the cough reflex, especially in adults. There are several factors that may underlie the cough reflex hypersensitivity and its persistence, such as age, sex, comorbidities, viral infection, exposure to irritants or environmental pollutants, and their interactions may determine the epidemiology of chronic cough in different countries. With a deeper understanding of disease pathophysiology and advanced research methodology, there are more attempts to investigate cough epidemiology using a large cohort of healthcare population data. This is a narrative overview of recent findings on the disease burden, risk factors, Asia-Pacific issues, and longitudinal outcomes in adults with chronic cough. This paper also discusses the approaches utilizing routinely collected data in cough research.

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“…Cough frequency measurement could be a novel objective marker of disease severity, and of directly monitoring response to treatment. This has been investigated in TB (21,116), a disease in which the currently-used objective markers of treatment response, including weight gain, radiographic improvement, and sterilisation of sputum microscopy are limited in responsiveness, sensitivity and specificity (117,118). Cough monitoring could also impact on the management of interstitial lung diseases, also in need of better clinical markers of severity and treatment response (119).…”

Section: Novel Applicationsmentioning

confidence: 99%

The present and future of cough counting tools

Hall¹,

Lozano²,

Estrada-Petrocelli³

et al. 2020

J Thorac Dis

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The widespread use of cough counting tools has, to date, been limited by a reliance on human input to determine cough frequency. However, over the last two decades advances in digital technology and audio capture have reduced this dependence. As a result, cough frequency is increasingly recognised as a measurable parameter of respiratory disease. Cough frequency is now the gold standard primary endpoint for trials of new treatments for chronic cough, has been investigated as a marker of infectiousness in tuberculosis (TB), and used to demonstrate recovery in exacerbations of chronic obstructive pulmonary disease (COPD).This review discusses the principles of automatic cough detection and summarises key currently and recently used cough counting technology in clinical research. It additionally makes some predictions on future directions in the field based on recent developments. It seems likely that newer approaches to signal processing, the adoption of techniques from automatic speech recognition, and the widespread ownership of mobile devices will help drive forward the development of real-time fully automated ambulatory cough frequency monitoring over the coming years. These changes should allow cough counting systems to transition from their current status as a niche research tool in chronic cough to a much more widely applicable method for assessing, investigating and understanding respiratory disease.

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Cough in pulmonary tuberculosis: Existing knowledge and general insights

Cited by 18 publications

References 77 publications

Mind the gap – Managing tuberculosis across the disease spectrum

Mind the gap – Managing tuberculosis across the disease spectrum

Epidemiology of adult chronic cough: disease burden, regional issues, and recent findings

The present and future of cough counting tools

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