Cost comparison analysis: pentaerythrithyl tetranitrate (PETN) and isosorbide dinitrate (ISDN) prescribed to diabetic patients in primary care practices in Germany

Icks, A.; Haastert, Burkhard; Rathmann, W; Schröder-Bernhardi, D; G, Giani

doi:10.5414/cpp45516

Cited by 6 publications

(4 citation statements)

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“…) and health policy strategies (Institute of Medicine , ; Icks et al. ) increasingly turning to provider decision making as one potential contributor to observed health disparities. This literature generally seeks to understand well‐documented patterns wherein physicians make different diagnostic and treatment decisions based on nonmedical factors, including patient characteristics (such as race, gender, age, socioeconomic status) (Arber et al.…”

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confidence: 99%

“…strategies (Institute of Medicine 2001Icks et al 2007) increasingly turning to provider decision making as one potential contributor to observed health disparities. This literature generally seeks to understand well-documented patterns wherein physicians make different diagnostic and treatment decisions based on nonmedical factors, including patient characteristics (such as race, gender, age, socioeconomic status) ), but also providers' individual attributes (gender, level of experience, specialty, place of training) (Shackelton-Piccolo et al 2011) and the characteristics of the health care settings in which they work, such as practice culture (Kralewski et al 2005a,b), work stress (Siegrist et al 2010), presence of health information technology (Ketcham et al 2009), and country (von dem Knesebeck et al 2008).…”

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confidence: 99%

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Physician Styles of Patient Management as a Potential Source of Disparities: Cluster Analysis from a Factorial Experiment

Lutfey

Gerstenberger

McKinlay

2012

Health Services Research

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Objective To identify styles of physician decision making (as opposed to singular clinical actions) and analyze their association with variations in the management of a vignette presentation of coronary heart disease (CHD). Data source Primary data were collected from primary care physicians in North and South Carolina. Study design In a balanced factorial experimental design, primary care physicians viewed one of 16 (24) video vignette presentations of CHD and provided detailed information about how they would manage the case. Data collection method 256 MD primary care physicians were interviewed face-to-face in North and South Carolina. Principal findings We identify 3 clusters depicting unique styles of CHD management that are robust to controls for physician (gender and level of experience) and patient characteristics (age, sex, socioeconomic status, and race) as well as key organizational features of physicians’ work settings. Physicians in Cluster 1 “Cardiac” (N=92) were more likely to focus on cardiac issues compared to their counterparts; physicians in Cluster 2 “Talkers” (N=93) were more likely to give advice and take additional medical history; while physicians in Cluster 3 “Minimalists” (N=71) were less likely than their counterparts to take action on any of the types of management behavior. Conclusions Variations in styles of decision making, which encompass multiple outcome variables and extend beyond individual-level demographic predictors, may add to our understanding of disparities in health quality and outcomes.

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confidence: 99%

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Physician Styles of Patient Management as a Potential Source of Disparities: Cluster Analysis from a Factorial Experiment

Lutfey

Gerstenberger

McKinlay

2012

Health Services Research

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“…Among the nitrate esters it is one of the most stable and least reactive and is often used in blasting devices including boosters and detonators (Armstrong and Elban 2006;Ree 1984;Shaffer 1987). Beyond its use in blasting, PETN is also used in pharmaceutical primary treatment of heart disease and diabetes (Icks et al 2007;Kristek 2000;Kristek et al 2007). However, as in other explosives, its physical properties are strongly related with internal factors such as crystallite particle size, crystal structure, dislocations, defects, and morphology Kunz 2000, 2001;Siviour et al 2004;Ter Horst et al 2001;Wang et al 2009).…”

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confidence: 99%

Effect of Zn doping on the sublimation rate of pentaerythritol tetranitrate using atomic force microscopy

Mridha

Weeks

2009

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A series of Zn ion-doped pentaerythritol tetranitrate (PETN) nanoislands in the form of thin films were prepared on Si substrates using spin coating. The effect of Zn concentrations on the sublimation energy was investigated by atomic force microscopy (AFM). The pure and Zn-doped nanoislands are imaged by AFM in contact mode at room temperature after annealing isothermally for a given time. The volume of the islands starts to decrease after annealing at 45 degrees C for pure PETN, whereas Zn-doped nanoislands start to decrease in height and volume after annealing at 55-58 degrees C. The minimum activation energy is found to be 29.7 Kcal/mol for 1,000 ppm Zn concentration. These studies are important for the long-term stabilization of PETN.

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“…It remains to be established whether these highly promising observations, that are mainly based on animal experimental data, may be translated to the clinical situation. First evidence for beneficial effects of PETN treatment in diabetic patients comes from a cost comparison analysis contrasting PETN and ISDN prescribed to diabetic patients in primary care practices in Germany [139]. PETN therapy tended to produce a saving in costs compared to ISDN therapy in diabetic patients when costs for comedication were taken into account and after adjustment for age and comorbidity.…”

Section: Conclusion and Clinical Implicationsmentioning

confidence: 99%

Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate

Oelze

Schuhmacher

Daiber

2010

Experimental Diabetes Research

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Organic nitrates represent a class of drugs which are clinically used for treatment of ischemic symptoms of angina as well as for congestive heart failure based on the idea to overcome the impaired NO bioavailability by “NO” replacement therapy. The present paper is focused on parallels between diabetes mellitus and nitrate tolerance, and aims to discuss the mechanisms underlying nitrate resistance in the setting of diabetes. Since oxidative stress was identified as an important factor in the development of tolerance to organic nitrates, but also represents a hallmark of diabetic complications, this may represent a common principle for both disorders where therapeutic intervention should start. This paper examines the evidence supporting the hypothesis that pentaerithrityl tetranitrate may represent a nitrate for treatment of ischemia in diabetic patients. This evidence is based on the considerations of parallels between diabetes mellitus and nitrate tolerance as well as on preliminary data from experimental diabetes studies.

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Cost comparison analysis: pentaerythrithyl tetranitrate (PETN) and isosorbide dinitrate (ISDN) prescribed to diabetic patients in primary care practices in Germany

Cited by 6 publications

References 0 publications

Physician Styles of Patient Management as a Potential Source of Disparities: Cluster Analysis from a Factorial Experiment

Physician Styles of Patient Management as a Potential Source of Disparities: Cluster Analysis from a Factorial Experiment

Effect of Zn doping on the sublimation rate of pentaerythritol tetranitrate using atomic force microscopy

Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate

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