Corynebacterium diphtheriae osteomyelitis in an immunocompetent child: A case report

Abstract

This case report shows that C. diphtheriae has not disappeared in the developed world and can be responsible of systemic infections.

Diversity of coryneforms found in infections following prosthetic joint insertion and open fractures

“…The literature on the subject lists only four single reports of coryneform osteomyelitis on the extremities in which species were determined [13][14][15][16]. Four further reports are extant on cases of septic arthritis [17][18][19][20].…”

Molecular epidemiology and characteristics of Corynebacterium diphtheriae and Corynebacterium ulcerans strains isolated in Italy during the 1990s

“…Non-toxigenic strains of C. diphtheriae have been increasingly reported as causes of invasive disease, including endocarditis, bacteraemia, septic arthritis and splenic abscesses (Alexander, 1984;Poilane et al, 1995;Patey et al, 1997;Belko et al, 2000;Mattos-Guaraldi et al, 2001;Funke et al, 1999). Nasopharyngeal carriage and disease caused by this organism have been documented amongst homeless people, intravenous drug users, alcoholics, Australian aborigines and the Northern Plains Indian Community (Gubler et al, 1998;Anonymous, 1997).…”

Toxigenic Corynebacteria: Adhesion, Invasion and Host Response

“…As mentioned above, besides evoking diphtheria, C. diphtheriae is associated with invasive infections, such as endocarditis, septic arthritis, splenic abscesses, bacteraemia and osteomyelitis, which are usually caused by non-toxigenic strains (Alexander 1984;Tiley et al 1993;Poilane et al 1995;Funke et al 1999;Belko et al 2000;Mattos-Guaraldi et al 2001). The clinical disease pattern of human diphtheroid arthritis can occur as an acute, purulent process or as a chronic arthritis with plasmacytic or histiocytic inflammation.…”