Cortical field potentials preceding self-paced forelimb movements and influences of cerebellectomy upon them in rats

Ohishi, Hiroko; Ichikawa, Jun; Matsuzaki, Ryuichi; Kyuhou, Shin ichi; Matsuura-Nakao, Kazuko; Seki, Tomomi; Gemba, Hisae

doi:10.1016/j.neulet.2003.08.012

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…The cerebellum is also important in preparation or execution of self-initiated movements (Sasaki et al, 1979;Ikeda et al, 1994;Ohishi et al, 2003;Purzner et al, 2007). The cerebellum is also involved in generating accurate timing of movements (Dreher and Grafman 2002;Kawashima et al 2000;Rao et al 1997), which is important for selfpaced movements.…”

Section: Define Index Areasmentioning

confidence: 99%

Effective connectivity of brain networks during self-initiated movement in Parkinson's disease

et al. 2011

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Section: Define Index Areasmentioning

confidence: 99%

Effective connectivity of brain networks during self-initiated movement in Parkinson's disease

et al. 2011

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“…Indirect coupling of the increase in hippocampal theta power to the contralateral forepaw control was also suggested by the long 6-s interval between the initiation of the theta increase and the start of lever pressing ( Fig 4 ). Ohishi et al (2003) reported that the evoked potential recorded in the contralateral forelimb motor cortex started 0.5–1.5 s before self-paced lever pressing and was eliminated by the ipsilateral hemicerebellectomy [ 33 ]. This suggested that pre-movement potential directly coupled to the control of contralateral forelimb started approximately 1 s before the lever press, which was much shorter than the start of increase in the hippocampal theta power in the present study.…”

Section: Discussionmentioning

confidence: 99%

Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats

et al. 2018

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Hippocampal theta oscillations have been implicated in working memory and attentional process, which might be useful for the brain-machine interface (BMI). To further elucidate the properties of the hippocampal theta oscillations that can be used in BMI, we investigated hippocampal theta oscillations during a two-lever choice task. During the task body-restrained rats were trained with a food reward to move an e-puck robot towards them by pressing the correct lever, ipsilateral to the robot several times, using the ipsilateral forelimb. The robot carried food and moved along a semicircle track set in front of the rat. We demonstrated that the power of hippocampal theta oscillations gradually increased during a 6-s preparatory period before the start of multiple lever pressing, irrespective of whether the correct lever choice or forelimb side were used. In addition, there was a significant difference in the theta power after the first choice, between correct and incorrect trials. During the correct trials the theta power was highest during the first lever-releasing period, whereas in the incorrect trials it occurred during the second correct lever-pressing period. We also analyzed the hippocampal theta oscillations at the termination of multiple lever pressing during the correct trials. Irrespective of whether the correct forelimb side was used, the power of hippocampal theta oscillations gradually decreased with the termination of multiple lever pressing. The frequency of theta oscillation also demonstrated an increase and decrease, before and after multiple lever pressing, respectively. There was a transient increase in frequency after the first lever press during the incorrect trials, while no such increase was observed during the correct trials. These results suggested that hippocampal theta oscillations reflect some aspects of preparatory and cognitive neural activities during the robot controlling task, which could be used for BMI.

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The cerebellum in Parkinson’s disease

Hallett

2013

Brain

631

548

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Parkinson's disease is a chronic progressive neurodegenerative disorder characterized by resting tremor, slowness of movements, rigidity, gait disturbance and postural instability. Most investigations on Parkinson's disease focused on the basal ganglia, whereas the cerebellum has often been overlooked. However, increasing evidence suggests that the cerebellum may have certain roles in the pathophysiology of Parkinson's disease. Anatomical studies identified reciprocal connections between the basal ganglia and cerebellum. There are Parkinson's disease-related pathological changes in the cerebellum. Functional or morphological modulations in the cerebellum were detected related to akinesia/rigidity, tremor, gait disturbance, dyskinesia and some non-motor symptoms. It is likely that the major roles of the cerebellum in Parkinson's disease include pathological and compensatory effects. Pathological changes in the cerebellum might be induced by dopaminergic degeneration, abnormal drives from the basal ganglia and dopaminergic treatment, and may account for some clinical symptoms in Parkinson's disease. The compensatory effect may help maintain better motor and non-motor functions. The cerebellum is also a potential target for some parkinsonian symptoms. Our knowledge about the roles of the cerebellum in Parkinson's disease remains limited, and further attention to the cerebellum is warranted.

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Cortical field potentials preceding self-paced forelimb movements and influences of cerebellectomy upon them in rats

Cited by 7 publications

References 15 publications

Effective connectivity of brain networks during self-initiated movement in Parkinson's disease

Effective connectivity of brain networks during self-initiated movement in Parkinson's disease

Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats

The cerebellum in Parkinson’s disease

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