Change in hippocampal theta oscillation associated with multiple lever presses in a bimanual two-lever choice task for robot control in rats

Tanaka, Norifumi; Sano, Katsunari; Rahman, Md. Ashrafur; Miyata, Ryota; Capi, Genci; Kawahara, Shigenori

doi:10.1371/journal.pone.0192593

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“…Classically, theta oscillations in the rat hippocampus have been associated with preparatory movements and locomotor behavior ( Vanderwolf and Heron, 1964 ). Many previous studies have reported that theta oscillations strongly correlate with locomotion speed ( Vanderwolf, 1969 , 1971 ; McFarland et al, 1975 ; Sławińska and Kasicki, 1998 ; Buzsáki, 2005 ; Hinman et al, 2011 ; Long et al, 2014 ), while others have suggested that theta oscillations are not purely associated to locomotion speed but better reflect movement intensity in general ( Whishaw and Vanderwolf, 1973 ; Bland et al, 2006 ; Tanaka et al, 2018 ). Since treadmill speed was always the same in our experiment (30 cm/s), according to the locomotion speed/movement intensity hypothesis, one would expect no changes in theta power across subsequent runs.…”

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confidence: 99%

Specific Increase of Hippocampal Delta Oscillations Across Consecutive Treadmill Runs

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Lobão-Soares

Tort

et al. 2020

Front. Behav. Neurosci.

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Running speed affects theta (6-10 Hz) oscillations, the most prominent rhythm in the rat hippocampus. Many reports have found a strong positive correlation between locomotion speed and the amplitude and frequency of theta oscillations. However, less is known about how other rhythms such as delta (0.5-4 Hz) and gamma (25-100 Hz) are affected, and how consecutive runs impact oscillatory activity in hippocampal networks. Here, we investigated whether the successive execution of short-term runs modulates local field potentials (LFPs) in the rat hippocampus. To do this, we trained Long-Evans rats to perform voluntary 15-s runs at 30 cm/s on a treadmill placed on the central stem of an eight-shape maze, in which they subsequently performed a spatial alternation task. We bilaterally recorded CA1 LFPs while rats executed at least 35 runs on the treadmillmaze apparatus. Within running periods, we observed progressive increases in delta band power along with decreases in the power of the theta and gamma bands across runs. Concurrently, the inter-hemispheric phase coherence in the delta band significantly increased, while in the theta and gamma bands exhibited no changes. Delta power and inter-hemispheric coherence correlated better with the trial number than with the actual running speed. We observed no significant differences in running speed, head direction, nor in spatial occupancy across runs. Our results thus show that consecutive treadmill runs at the same speed positively modulates the power and coherence of delta oscillations in the rat hippocampus.

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