Cortical asymmetries in normal, mild cognitive impairment, and Alzheimer's disease

Kim, Jong Hun; Lee, Jong Weon; Kim, Geon Ha; Roh, Jee Hoon; Kim, Minjeong; Seo, Sang Won; Kim, Sung Tae; Jeon, Seun; Lee, Jongmin; Heilman, Kenneth M.; Na, Duk L.

doi:10.1016/j.neurobiolaging.2011.06.026

Cited by 56 publications

(49 citation statements)

References 39 publications

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“…They are also consistent with previous studies linking MetS to higher numbers of silent infacts (Kim, 2012) and ultrastructural tissue damage in the frontal and temporal lobes on diffusion tensor imaging (Kwon, 2006). As cortical thinning is also related to poorer cognitive function (Segura, 2009), this study could further elucidate the mechanisms underlying the association between MetS risk factors and cognitive function.…”

Section: Discussionsupporting

confidence: 92%

Inflammation as a mediator of the relationship between cortical thickness and metabolic syndrome

Kaur

Gonzales

Eagan

et al. 2014

Brain Imaging and Behavior

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Objective Metabolic Syndrome (MetS), the clustering of obesity, high blood pressure, and disordered glucose and lipid/lipoprotein metabolism within a single individual, is associated with poorer cognitive function. It has been hypothesized that cognitive impairment in MetS occurs primarily within the context of inflammation. MetS risk factors are also associated with thinning of the cerebral cortex. However, the mechanisms by which MetS and inflammation affect the brain are poorly understood. The present study used statistical mediation to examine the relationship between MetS risk factors, cortical thickness in a priori regions of interest (ROIs) and inflammation. ROIs were chosen from the previous literature. Research Design and Methods Forty-three adults between the ages of 40 and 60 years underwent a health screen, neuropsychological testing and structural magnetic resonance imaging. Serum levels of pro-inflammatory markers (interleukin 1, interleukin 2, interleukin 6 and C-Reactive Protein) were measured using enzyme-linked immunosorbent assays. Results A higher number of MetS risk factors were associated with thinning in the inferior frontal ROI (β=−0.35, p = 0.019) as well as higher levels of serum interleukin 2 (β=0.31, p=0.04). A higher level of serum interleukin 2 was also associated with reduced thickness in the inferior frontal gyrus (β=−0.41, p=0.013). After accounting for the effects of interleukin 2, the number of MetS risk factors was no longer associated with cortical thickness in the inferior frontal gyrus indicating successful statistical mediation. Conclusions The results indicate a potentially important role for inflammation in linking MetS to cortical thinning and cognitive vulnerability.

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Section: Discussionsupporting

confidence: 92%

Inflammation as a mediator of the relationship between cortical thickness and metabolic syndrome

Kaur

Gonzales

Eagan

et al. 2014

Brain Imaging and Behavior

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“…However, all these models were age adjusted. The normal R hemisphere dominant hippocampal volume asymmetry is effaced as MCI progresses to AD [55, 56]. Positron emission tomography imaged amyloid-β deposition is largely symmetrical [57], but bilateral amyloid-β deposition in DMN-related structures is associated with greater right hemisphere atrophy [58].…”

Section: Discussionmentioning

confidence: 99%

The Default Mode Network and Related Right Hemisphere Structures may be the Key Substrates of Dementia

Royall

Palmer

Vidoni

et al. 2012

JAD

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We have employed structural equation models to explicitly distinguish dementia-relevant variance in cognitive task performance (i.e., d) from the variance that is unrelated to a dementing process (i.e., g′). Together g′ and d comprise Spearman’s “g”. Although d represents only a minor fraction of the total variance in cognitive task performance, it is more strongly associated with dementia severity than is g′. In this analysis, we replicate d in a new dataspace, the University of Kansas Brain Aging Project, and associate it specifically with regional grey matter atrophy by voxel-based morphometry of magnetic resonance imaging data. The latent variable d localizes to elements of the default mode network and related structures in the R hemisphere.

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“…The left-right laterality index (L-R index) in WMH was calculated using the following formula [17,18]: All patients, as well as four normal control participants at Samsung Medical Center and nine normal control participants at Asan Medical Center, underwent [ 11 C] PiB PET scans using a Discovery STe PET/CT scanner (GE Medical Systems, Milwaukee, WI, USA). To minimize variation due to scanner differences, the settings and scanning protocol were identical across tests.…”

Section: Mr Imaging and Analysismentioning

confidence: 99%

The Role of Cerebrovascular Disease in Amyloid Deposition

Noh

Seo

Jeon

et al. 2016

JAD

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Cortical asymmetries in normal, mild cognitive impairment, and Alzheimer's disease

Cited by 56 publications

References 39 publications

Inflammation as a mediator of the relationship between cortical thickness and metabolic syndrome

Inflammation as a mediator of the relationship between cortical thickness and metabolic syndrome

The Default Mode Network and Related Right Hemisphere Structures may be the Key Substrates of Dementia

The Role of Cerebrovascular Disease in Amyloid Deposition

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