Corrosion of Metallic Biomaterials: A Review

Eliaz, Noam

doi:10.3390/ma12030407

Cited by 552 publications

(409 citation statements)

References 290 publications

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“…In joint replacements, metal ions are generated by corrosive degradation of metal wear debris and by tribocorrosion at the exposed metal surfaces of the implant. In vivo , a passive oxide film is spontaneously formed on the metallic surface which protects the implant material from corrosion and inhibits the release of metal ions. However, repetitive mechanical stress leads to the disruption of this protective oxide film hereby facilitating corrosion damage and metal ion release.…”

Section: Introductionmentioning

confidence: 99%

Blood Metal Ion Release After Primary Total Knee Arthroplasty: A Prospective Study

Reiner

Sorbi

Müller

et al. 2020

Orthopaedic Surgery

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Objectives:To investigate the course of in vivo blood metal ion levels in patients undergoing primary total knee arthroplasty (TKA) and to investigate potential risk factors associated with metal ion release in these patients. Methods:Twenty-five patients with indication for TKA were included in this prospective study. Whole blood metal ion analysis was performed pre-operatively and at 1 week, 6 weeks, 3 months, 6 months, and 12 months postoperatively. Clinical scores were obtained using the American Knee Society Score (AKSS) and the Oxford Knee Score (OKS) at each follow-up and patientsʼ activity levels were assessed by measuring the mean annual walking cycles at 12 months follow-up. Anteroposterior and lateral radiographs of the operated knee were evaluated postoperatively and at 12-month follow-up with regard to implant position and radiological signs of implant loosening. Correlation analysis using multivariate linear regression was performed to investigate the influence of different variables (age, gender, functional scores, number of walking cycles, and body mass index [BMI]) on blood cobalt ion concentrations.Results: Mean metal ion levels of cobalt, chromium, molybdenum, and titanium were 0.28 μg/L (SD, 0.14), 0.43 μg/L (SD, 0.49), 0.62 μg/L (SD, 0.45), and 1.96 μg/L (SD, 0.98), respectively at 12-month follow-up. Mean cobalt ion levels significantly increased 1-year after surgery compared to preoperative measurements. There was no statistically significant increase of mean metal ion levels of chromium, titanium, and molybdenum at 1-year follow-up. Overall, metal ion levels were low and no patient demonstrated cobalt ion levels above 1 μg/L. Postoperative radiographs demonstrated wellaligned TKAs in all patients and no signs of osteolysis or implant loosening were detected at 1-year follow-up. Both the AKSS and OKS significantly improved during the course of the study up to the final follow-up. Multivariate regression analysis did not show a statistically significant correlation between the tested variables and blood cobalt ion concentrations. Conclusion:A statistically significant increase of mean cobalt ion concentration at 1-year follow-up was found in this cohort of patients with well-functioning TKA, although overall blood metal ion levels were relatively low. Despite low systemic metal ion concentrations seen in this cohort, the local effects of increased metal ion concentrations in the periprosthetic environment on the long-term outcome of TKA should be further investigated.

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Section: Introductionmentioning

confidence: 99%

Blood Metal Ion Release After Primary Total Knee Arthroplasty: A Prospective Study

Reiner

Sorbi

Müller

et al. 2020

Orthopaedic Surgery

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“…Concerning the types of material wear, it has been reported in the literature that tribocorrosion can be classified as fretting and erosion corrosion, abrasion corrosion, pitting corrosion, sliding corrosion, or fatigue corrosion (Chaturvedi, 2009;Sikora et al, 2018). Among the types of material wear, fretting wear, and erosion corrosion occur when contacting surfaces have a small relative motion between them under load in the presence of a solution (Eliaz, 2019). This type of material wear would occur inevitably between dental implant and bone interface during masticatory function (Gao et al, 2012).…”

Section: Tribocorrosion Test In the Laboratorymentioning

confidence: 99%

Progression of Bio-Tribocorrosion in Implant Dentistry

et al. 2020

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Oral rehabilitation devices are susceptible to bio-tribocorrosion phenomena in the oral environment due to the synergism of wear, chemical, biochemical, and microbiological processes. This review summarizes the clinical problems and advances obtained based on current scientific evidence as well as the influence of tribological fundamentals, testing methodologies, and protocols in tribocorrosion analyses. The main clinical question related to oral rehabilitation with dental implants is the treatment failure, which is influenced by material degradation. Titanium-based implants are exposed to wear and corrosion challenges in the oral environment since the implantation and along the lifetime service. The titanium (Ti) properties such as structural material, connection design, surface treatments, alloying elements are influencing factors for material behavior. In addition, wear-corrosion factors such as cyclic loads, micromovements, oral biofilm, decontamination methods are also associated with dental implants degradation. These environmental conditions to which dental implants are submitted leads to the release of Ti particles and ions with cytotoxic and harmful effects on peri-implant surrounding tissues. In this context, the current state of the art of bio-tribocorrosion over the last decade has been steadily increasing to understand material degradation. The basic test system used to translate the tribocorrosion phenomena in the oral environment to the bench consists of electrochemical and tribological synergic analysis. The mechanical (applied load, frequency, stroke distance, and number of cycles) and electrochemical (solution composition, concentration of anions, and pH) test conditions are determinants for materials tribocorrosion performance. To overcome the tribocorrosion phenomena some strategies have been used such as alloying elements for Ti-alloys manufacture, surface treatments, and biomolecules immobilization. Further studies need to have the tribocorrosion analyses as the basis for new smart materials development considering the importance of such aspects for the biomaterial clinical behavior. Finally, tribological tests are relevant strategies for understanding the mechanisms of degradation in the oral environment and for providing a way to improve the clinical outcomes of dental implants.

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“…At metal surfaces, electrochemical reactions can contribute to the generation of reactive species via reduction reactions (Eliaz, ):

O_{2} + {2H}_{2} normalO + {2e}^{-} \to H_{2} O_{2} + 2 {(OH)}^{-}

H_{2} O_{2} + {2e}^{-} \to 2 {(OH)}^{-}

O_{2} + H_{2} normalO + e^{-} \to HO ˙_{2} + {(OH)}^{-}

HO ˙_{2} + H_{2} normalO \to H_{2} O_{2} + HO ˙

…”

Section: Potential Impact Of Oxidative Stress In Arthroplastymentioning

confidence: 99%

Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty

et al. 2020

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The interplay between implant design, biomaterial characteristics, and the local microenvironment adjacent to the implant is of utmost importance for implant performance and success of the joint replacement surgery. Reactive oxygen and nitrogen species (ROS/RNS) are among the various factors affecting the host as well as the implant components. Excessive formation of ROS and RNS can lead to oxidative stress, a condition that is known to damage cells and tissues and also to affect signaling pathways. It may further compromise implant longevity by accelerating implant degradation, primarily through activation of inflammatory cells. In addition, wear products of metallic, ceramic, polyethylene, or bone cement origin may also generate oxidative stress themselves. This review outlines the generation of free radicals and

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Corrosion of Metallic Biomaterials: A Review

Cited by 552 publications

References 290 publications

Blood Metal Ion Release After Primary Total Knee Arthroplasty: A Prospective Study

Blood Metal Ion Release After Primary Total Knee Arthroplasty: A Prospective Study

Progression of Bio-Tribocorrosion in Implant Dentistry

Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty

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