Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty

Hameister, Rita; Kaur, Charanjit; Dheen, S. Thameem; Lohmann, Christoph H.; Singh, Gurpal

doi:10.1002/jbm.b.34546

Cited by 58 publications

(38 citation statements)

References 148 publications

(159 reference statements)

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“…Oxidative stress is defined as a disruption in homeostasis between antioxidants and oxidants, and more specifically, an accumulation of reactive oxidative species (ROS) and reactive nitrogen species (RNS) (Apak et al, 2016;Hameister et al, 2020). ROS belongs to a family of compounds containing partially reduced oxygen species, such as O 2 -and HO-, that are generated primarily by the electron transport chain during aerobic respiration (Zhao et al, 2019).…”

Section: Lipids and Oxidative Stressmentioning

confidence: 99%

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

2020

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Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy function as well as the most common pathological conditions of the brain. Demographic factors, genetics, and lifestyles are the major factors that influence lipid metabolism and are also the key components of lipid disruption in Alzheimer's disease (AD). Additionally, the most common genetic risk factor of AD, APOE 4 genotype, is involved in lipid transport and metabolism. We propose that lipids are at the center of Alzheimer's disease pathology based on their involvement in the blood-brain barrier function, amyloid precursor protein (APP) processing, myelination, membrane remodeling, receptor signaling, inflammation, oxidation, and energy balance. Under healthy conditions, lipid homeostasis bestows a balanced cellular environment that enables the proper functioning of brain cells. However, under pathological conditions, dyshomeostasis of brain lipid composition can result in disturbed BBB, abnormal processing of APP, dysfunction in endocytosis/exocytosis/autophagocytosis, altered myelination, disturbed signaling, unbalanced energy metabolism, and enhanced inflammation. These lipid disturbances may contribute to abnormalities in brain function that are the hallmark of AD. The wide variance of lipid disturbances associated with brain function suggest that AD pathology may present as a complex interaction between several metabolic pathways that are augmented by risk factors such as age, genetics, and lifestyles. Herewith, we examine factors that influence brain lipid composition, review the association of lipids with all known facets of AD pathology, and offer pointers for potential therapies that target lipid pathways.

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Section: Lipids and Oxidative Stressmentioning

confidence: 99%

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

2020

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“…Oxidative stress is defined as an imbalance between the production of reactive oxygen species (ROS) and their elimination by protective mechanisms. Imbalance in this protective mechanism can lead to the damage of cellular component such as DNA, proteins, and lipids [13]. ROS are generated by aerobic metabolism in mitochondria [14][15][16] and include superoxide anions (O2-) hydrogen peroxide e (H2O2) and free radicals such as hydroxyl radical (OH-).…”

Section: Oxidative Stress and Bonementioning

confidence: 99%

Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis

Galliera

Massaccesi

Banfi

et al. 2021

Clinic Rev Bone Miner Metab

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The success of implant performance and arthroplasty is based on several factors, including oxidative stress-induced osteolysis. Oxidative stress is a key factor of the inflammatory response. Implant biomaterials can release wear particles which may elicit adverse reactions in patients, such as local inflammatory response leading to tissue damage, which eventually results in loosening of the implant. Wear debris undergo phagocytosis by macrophages, inducing a low-grade chronic inflammation and reactive oxygen species (ROS) production. In addition, ROS can also be directly produced by prosthetic biomaterial oxidation. Overall, ROS amplify the inflammatory response and stimulate both RANKL-induced osteoclastogenesis and osteoblast apoptosis, resulting in bone resorption, leading to periprosthetic osteolysis. Therefore, a growing understanding of the mechanism of oxidative stress-induced periprosthetic osteolysis and anti-oxidant strategies of implant design as well as the addition of anti-oxidant agents will help to improve implants’ performances and therapeutic approaches.

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“…In light of published references, under normal circumstances, there is a dynamic balance between the production of ROS and the antioxidant capacity of cells [ 25 ]. Furthermore, ROS are intermediate products and by-products that are produced in the electron transport in mitochondria [ 26 , 27 ]. Notably, many enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GPx), have a high ROS scavenging capacity [ 8 ].…”

Section: Oxidative Stress and Asdmentioning

confidence: 99%

The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD)

Dong

et al. 2020

Oxidative Medicine and Cellular Longevity

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Autism spectrum disorders (ASDs) are a kind of neurodevelopmental disorder with rapidly increasing morbidity. In recent years, many studies have proposed a possible link between ASD and multiple environmental as well as genetic risk factors; nevertheless, recent studies have still failed to identify the specific pathogenesis. An analysis of the literature showed that oxidative stress and redox imbalance caused by high levels of reactive oxygen species (ROS) are thought to be integral parts of ASD pathophysiology. On the one hand, this review aims to elucidate the communications between oxidative stress, as a risk factor, and ASD. As such, there is also evidence to suggest that early assessment and treatment of antioxidant status are likely to result in improved long-term prognosis by disturbing oxidative stress in the brain to avoid additional irreversible brain damage. Accordingly, we will also discuss the possibility of novel therapies regarding oxidative stress as a target according to recent literature. On the other hand, this review suggests a definite relationship between ASD and an unbalanced gastrointestinal tract (GIT) microbiota (i.e., GIT dysbiosis). A variety of studies have concluded that the intestinal microbiota influences many aspects of human health, including metabolism, the immune and nervous systems, and the mucosal barrier. Additionally, the oxidative stress and GIT dysfunction in autistic children have both been reported to be related to mitochondrial dysfunction. What is the connection between them? Moreover, specific changes in the GIT microbiota are clearly observed in most autistic children, and the related mechanisms and the connection among ASD, the GIT microbiota, and oxidative stress are also discussed, providing a theory and molecular strategies for clinical practice as well as further studies.

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Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty

Cited by 58 publications

References 148 publications

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies

Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis

The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD)

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