Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with Postmortem Examination

Widjaja, Elysa; Geibprasert, Sasikhan; Mahmoodabadi, S. Zarei; Brown, N.E.; Shannon, Patrick

doi:10.3174/ajnr.a2193

Cited by 15 publications

(11 citation statements)

References 9 publications

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“…Severe ventriculomegaly . Independent of pathogenesis, severe ventriculomegaly presents a common phenotype of marked thinning of the cerebral mantle with absence of normal cerebral lamination.…”

Section: Discussionmentioning

confidence: 99%

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Sonographic assessment of normal and abnormal patterns of fetal cerebral lamination

Pugash

Hendson

Dunham

et al. 2012

Ultrasound in Obstet & Gyne

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Section: Discussionmentioning

confidence: 99%

“…Abnormal fetal cerebral lamination is an indicator of abnormal brain development on histopathological and fetal MRI examination 37 . Sonographically, we observed three patterns of abnormal lamination.…”

Section: Abnormal Cerebral Lamination Patternsmentioning

confidence: 99%

Sonographic assessment of normal and abnormal patterns of fetal cerebral lamination

Pugash

Hendson

Dunham

et al. 2012

Ultrasound in Obstet & Gyne

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“…As well as cortical changes, myelination of the white matter, which generally progresses from caudal to rostral, will continue through the first few years of infancy 18 . A knowledge of expected signal changes seen on T1-weighted images during transient foetal lamination (occurring between 15-26 weeks gestation) has been shown on PMMR to have a high sensitivity (96.2%) and specificity (89.7%) 19 . After 26 weeks gestation, the lamination patterns in the cerebral wall gradually disappear and are no longer reliable indicators 20 .…”

Section: Normal Post Mortem Findingsmentioning

confidence: 99%

Post-mortem magnetic resonance (PMMR) imaging of the brain in fetuses and children with histopathological correlation

et al. 2017

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Post-mortem magnetic resonance (PMMR) imaging is rapidly emerging as an alternative, "less invasive", and more widely accepted investigative approach for perinatal deaths in the UK. PMMR has a high diagnostic accuracy for congenital and acquired fetal neuropathological anomalies compared to conventional autopsy, and is particularly useful when autopsy is non-diagnostic. The main objectives of this review are to describe and illustrate the range of common normal and abnormal central nervous system (CNS) findings encountered during PMMR investigation. This article covers the standard PMMR sequences used at our institution, normal physiological post-mortem findings, and a range of abnormal developmental and acquired conditions. The abnormal findings include diseases ranging from neural tube defects, posterior fossa malformations, those of forebrain and commissural development as well as neoplastic, haemorrhagic, and infectious aetiologies. Neuropathological findings at conventional autopsy accompany many of the conditions we describe, allowing readers to better understand the underlying disease processes and imaging appearances.

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“…1 ). Different alterations in foetal brain lamination have been described as potential biomarkers of underlying diseases such as genetic disorders, neuronal migration disorders, and even as a consequence of other acquired disorders such as ventriculomegaly or hypoxic-ischaemic injuries [ 25 ]. However, after 26 weeks of gestation, the lamination patterns in the cerebral wall gradually disappear [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Perinatal post-mortem magnetic resonance imaging (MRI) of the central nervous system (CNS): a pictorial review

et al. 2021

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Central nervous system (CNS) abnormalities cause approximately 32–37.7% of terminations of pregnancy (TOP). Autopsy is currently the gold standard for assessing dead foetuses and stillborn. However, it has limitations and is sometimes subject to parental rejection. Recent studies have described post-mortem foetal magnetic resonance imaging (MRI) as an alternative and even complementary to autopsy for CNS assessment. Radiologists now play a key role in the evaluation of perinatal deaths. Assessment of foetal CNS abnormalities is difficult, and interpretation of foetal studies requires familiarisation with normal and abnormal findings in post-mortem MRI studies as well as the strengths and limitations of the imaging studies. The purpose of this pictorial review is to report our experience in the post-mortem MRI evaluation of the CNS system, including a description of the protocol used, normal CNS findings related to post-mortem status, abnormal CNS findings in our sample, and the correlation of these findings with histopathological results.

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Corroboration of Normal and Abnormal Fetal Cerebral Lamination on Postmortem MR Imaging with Postmortem Examination

Cited by 15 publications

References 9 publications

Sonographic assessment of normal and abnormal patterns of fetal cerebral lamination

Sonographic assessment of normal and abnormal patterns of fetal cerebral lamination

Post-mortem magnetic resonance (PMMR) imaging of the brain in fetuses and children with histopathological correlation

Perinatal post-mortem magnetic resonance imaging (MRI) of the central nervous system (CNS): a pictorial review

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