Corrigendum to “Antimicrobial properties of silver-containing wound dressings: a microcalorimetric study”

O'Neill, M; Vine, George J.; Beezer, Anthony E.; Bishop, Alistair H.; Hadgraft, Jonathan; Labetoulle, Chloé; Walker, Michael J.; Bowler, Philip G

doi:10.1016/j.ijpharm.2003.11.007

Cited by 12 publications

(10 citation statements)

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“…The potential for batch microcalorimetry to study very complex heterogeneous systems was demonstrated [76] by the assay of silver-containing antimicrobial wound dressings.…”

Section: Heterogeneous Systemsmentioning

confidence: 99%

The Analysis of Microorganisms by Microcalorimetry in the Pharmaceutical Industry

Vine¹,

Bishop²

2005

CPB

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Many features of microorganisms make them pre-eminently suitable for study by microcalorimetry. They have thus, in the past, been the basis of fundamental studies in metabolism and cellular physiology. In this review we look at the application of calorimetry to the impact of bacteria and fungi on the pharmaceutical industry both in the exploitation of useful microorganisms and the fight against harmful ones. Obviously they are of great relevance to the pharmaceutical industry as agents of human disease, with more antimicrobial products registered for production than for any other type of human affliction. Microcalorimetry offers the opportunity to study microorganisms in real time and in heterogeneous systems, allowing for more descriptive and representative analysis. Other advantages that microcalorimetry confers over traditional microbiological techniques are reductions in time, better reproducibility and simplicity. Also the manufacture of all pharmaceutical products requires the exclusion of microorganisms to a greater or lesser degree. The enumeration and identification of such contaminants is of great importance for the well-being of patients and to maintain the integrity of the product. New techniques are required to increase the reliability and sensitivity over conventional methods. Finally, as our understanding of biology develops, the sophistication of therapeutic agents available, such as vaccines, cytokines and engineered antibodies, is increasing. Necessarily, prokaryotic and eukaryotic cells, possibly transformed with the appropriate genes, are the producers of such proteins. Microcalorimetry offers a sensitive means of developing the conditions for optimum production of such products in active form since it gives instantaneous information on the physiology of the producer cell.

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“…The potential for batch microcalorimetry to study very complex heterogeneous systems was demonstrated [76] by the assay of silver-containing antimicrobial wound dressings.…”

Section: Heterogeneous Systemsmentioning

confidence: 99%

The Analysis of Microorganisms by Microcalorimetry in the Pharmaceutical Industry

Vine¹,

Bishop²

2005

CPB

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“…In bioinorganic chemistry of coinage metal(I) complexes, there have been reported various studies of gold(I) complexes related to their antiarthritic [1][2][3], antitumor [2][3][4][5][6], anti-HIV [2,3] and antimicrobial activities [7][8][9][10][11][12] and those of silver(I) complexes related to their antiethylene [13][14][15], antimicrobial [16][17][18][19][20][21][22][23][24], antitumor [25] and antiviral activities [26,27]. The molecular design of such silver(I) and gold(I) complexes is an intriguing aspect of the bioinorganic chemistry of metal-based drugs.…”

mentioning

confidence: 99%

Synthesis of novel gold(I) complexes derived by AgCl-elimination between [AuCl(PPh3)] and silver(I) heterocyclic carboxylates, and their antimicrobial activities. Molecular structure of [Au(R,S-Hpyrrld)(PPh3)] (H2pyrrld = 2-pyrrolidone-5-carboxylic acid)

Noguchi¹,

Hara²,

Sugie³

et al. 2006

Inorganic Chemistry Communications

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“…Further, it is possible to monitor bacterial activity in the presence of antimicrobial agents and/or medical devices and implants because there is no requirement for optical clarity of the test system. IMC has been used to follow microbiological activity in a wide range of applications, including for monitoring and quantifying soil microbial activity and contamination [2][3], treatment of sewage [4], detecting infection in and contamination of clinical products and samples [5], quantifying the efficacy of antimicrobial compounds [6][7], including the mode of action of bacteriostatic or bactericidal compounds [8] and antiviral compounds [9][10] and looking at spoilage of food [11]. A few studies have been conducted on defined mixed cultures with the aim of investigating the relationship between two or more bacteria (for instance, [12][13][14]).…”

Section: Introductionmentioning

confidence: 99%

Development of a flow system for studying biofilm formation on medical devices with microcalorimetry

Said

Walker

Parsons

et al. 2015

Methods

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Isothermal microcalorimetry (IMC) is particularly suited to the study of microbiological samples in complex or heterogeneous environments because it does not require optical clarity of the sample and can detect metabolic activity from as few as 10 4 CFU/mL cells.While the use of IMC for studying planktonic cultures is well established, in the clinical environment bacteria are most likely to be present as biofilms. Biofilm prevention and eradication present a number of challenges to designers and users of medical devices and implants, since bacteria in biofilm colonies are usually more resistant to antimicrobial agents.Analytical tools that facilitate investigation of biofilm formation are therefore extremely useful.While it is possible to study pre-prepared biofilms in closed ampoules, better correlation with in-vivo behaviour can be achieved using a system in which the bacterial suspension is flowing. Here, we discuss the potential of flow calorimetry for studying biofilms and report the development of a simple flow system that can be housed in a microcalorimeter. The use of the flow system is demonstrated with biofilms of Staphylococcus aureus.

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Corrigendum to “Antimicrobial properties of silver-containing wound dressings: a microcalorimetric study”

Cited by 12 publications

References 0 publications

The Analysis of Microorganisms by Microcalorimetry in the Pharmaceutical Industry

The Analysis of Microorganisms by Microcalorimetry in the Pharmaceutical Industry

Synthesis of novel gold(I) complexes derived by AgCl-elimination between [AuCl(PPh3)] and silver(I) heterocyclic carboxylates, and their antimicrobial activities. Molecular structure of [Au(R,S-Hpyrrld)(PPh3)] (H2pyrrld = 2-pyrrolidone-5-carboxylic acid)

Development of a flow system for studying biofilm formation on medical devices with microcalorimetry

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