Synthesis of novel gold(I) complexes derived by AgCl-elimination between [AuCl(PPh3)] and silver(I) heterocyclic carboxylates, and their antimicrobial activities. Molecular structure of [Au(R,S-Hpyrrld)(PPh3)] (H2pyrrld = 2-pyrrolidone-5-carboxylic acid)

Noguchi, Ryusuke; Hara, Akihiro; Sugie, Akiyoshi; Nomiya, Kenji

doi:10.1016/j.inoche.2006.01.001

Cited by 44 publications

(33 citation statements)

References 30 publications

(42 reference statements)

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“…Moreover, gold complexes have shown considerable cytotoxic and antimicrobial activity [21][22][23]. In this study, we report the combination effect of Au 3+ on antibacterial activity of different antibiotics against clinically resistant strains of P. aeruginosa, S. aureus and E. coli.…”

Section: Introductionmentioning

confidence: 87%

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

et al. 2012

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Despite much success in drug design and development, Pseudomonas aeruginosa is still considered as one of the most problematic bacteria due to its ability to develop mutational resistance against a variety of antibiotics. In search for new strategies to enhance antibacterial activity of antibiotics, in this work, the combination effect of gold materials including trivalent gold ions (Au 3+ ) and gold nanoparticles (Au NPs) with 14 different antibiotics was investigated against the clinical isolates of P. aeruginosa, Staphylococcus aureus and Escherichia coli. Disk diffusion assay was carried out, and test strains were treated with the sub-inhibitory contents of gold nanomaterial. Results showed that Au NPs did not increase the antibacterial effect of antibiotics at tested concentration (40 μg/disc). However, the susceptibility of resistant P. aeruginosa increased in the presence of Au 3+ and methicillin, erythromycin, vancomycin, penicillin G, clindamycin and nalidixic acid, up to 147 %. As an individual experiment, the same group of antibiotics was tested for their activity against clinical isolates of S. aureus, E. coli and a different resistant strain of P. aeruginosa in the presence of sub-inhibitory contents of Au 3+, where Au 3+ increased the susceptibility of test strains to methicillin, erythromycin, vancomycin, penicillin G, clindamycin and nalidixic acid. Our finding suggested that using the combination of sub-inhibitory concentrations of Au 3+ and methicillin, erythromycin, nalidixic acid or vancomycin may be a promising new strategy for the treatment of highly resistant P. aeruginosa infections.

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Section: Introductionmentioning

confidence: 87%

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

et al. 2012

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“…In this last field, the compounds under investigation include a major collection of the type R 3 PAuL, in which the gold atom is coordinated to a phosphine ligand and L is an O- [26,27], N- [28,29], Cl- [30] or S- [29,[31][32][33][34][35] 2 ], Na 3 [Au(mna) 2 ] (H 2 mna 02-mercaptonicotinic acid) [13] and the cationic complexes [Au(L) 2 ](NO 3 ) 3 (L01-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) [34]. For the latter ligand, compounds of the type [Au(L)]Br, [Au(L)] SCN and [Au(L)]Cl were also prepared [34] and the coexistence of an S-donor ligand and a Cl ligand was also described for [LAuCl] (where L 02,3-diphenyl-1,3,4-thiadiazolium-5-thiolato-S exo ) [36].…”

Section: (L)] [Hq][ag(l)] (Hq0diisopropylammonium)mentioning

confidence: 99%

Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates

et al. 2012

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Reaction of NaAuCl 4 ·H 2 O and thiodiglycol (1:3 molar ratio) with 3-(aryl)-2-sulfanylpropenoic acids, C NMR spectroscopy. The antimicrobial activities of the complexes against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa and carbapenem-resistant P. aeruginosa were evaluated and compared to those of the equivalent silver(I) complexes. The comparison shows that the gold compounds generally show better activity than the silver analogues against S. aureus and B. subtilis, but low sensitivity against E. coli, P. aeruginosa and C. albicans, suggesting a different mode of antimicrobial action for equivalent silver and gold compounds.

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“…; biomolecule based coordination complexes 46 have never been the focus from the standpoint of magnetism phenomena, in spite of the recently explored spectra of applications presented by this emerging class of materials. 46 [53][54][55][56][57] Importantly, this oxo-derivative of secondary amino acid being a noteworthy metabolite in the glutathione cycle is one of the vital biomolecule possessing memory-enhancement effect, hair-follicle growth and dermal penetration enhancing consequences. [58][59][60] Hence, the employment of PGA in the construction of 3d-4f based coordination complexes seems quite a daunting task, considering unification of the dual features of biocompatibility and magnetism in a single discrete coordination entity.…”

Section: Introductionmentioning

confidence: 99%

Chiral biomolecule based dodecanuclear dysprosium(iii)–copper(ii) clusters: structural analyses and magnetic properties

Joarder

Mukherjee

Patil

et al. 2015

Inorg. Chem. Front.

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a The isostructural family of three dodecanuclear chiral M4Cu8 (M = Dy, Y) complexes has been synthesized by adopting a mixed-ligand strategy, wherein one of the constituent linker Pyroglutamic acid, a recognized biomolecule has been credibly functioning as the chiral precursor imparting the chirality to the aforementioned complex. The highly symmetric new-fangled M4Cu8 cordination-core, comprising of four square-symmetricallly coordinated Dy/Y-vertex sharing M2Cu2 cubane units has been synthesized as an unprecedented discrete coordination complex, which has been analysed by magnetic measuremnets.

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Synthesis of novel gold(I) complexes derived by AgCl-elimination between [AuCl(PPh3)] and silver(I) heterocyclic carboxylates, and their antimicrobial activities. Molecular structure of [Au(R,S-Hpyrrld)(PPh3)] (H2pyrrld = 2-pyrrolidone-5-carboxylic acid)

Cited by 44 publications

References 30 publications

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

The combination effects of trivalent gold ions and gold nanoparticles with different antibiotics against resistant Pseudomonas aeruginosa

Synthesis and antimicrobial activities of gold(I) sulfanylcarboxylates

Chiral biomolecule based dodecanuclear dysprosium(iii)–copper(ii) clusters: structural analyses and magnetic properties

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