Correlations between allergen-specific IgE serum levels in patients with allergic conjunctivitis in spring

Arimoto

et al. 2007

Eye

Purpose External allergens are the main causative factor in the pathogenesis of allergic diseases; however, little is known about internal factors such as the biometrical structure of the eye. We investigated the relationship between refractive error and allergic conjunctivitis in order to reveal possible insights into the pathogenesis in 1015 subjects. Methods The patients were divided into four groups: contact lens wearers with allergic conjunctivitis (n ¼ 73), contact lens wearers without allergic conjunctivitis (n ¼ 59), non-contact lens wearers with allergic conjunctivitis (n ¼ 224), and non-contact lens wearers without allergic conjunctivitis (n ¼ 659). The spherical power, cylindrical power, corneal radius, and minimum and maximum corneal refractive powers were measured in all subjects. Results In the non-contact lens wearers, the spherical equivalent and spherical power were significantly lower in patients with allergic conjunctivitis than in patients without allergic conjunctivitis (À3.0173.83 D vs À1.3673.08 D, Po0.0001, and À2.6473.63 D vs À1.0572.88 D, Po0.0001, respectively), while there was no significant difference in any of the parameters between the contact lens wearers with and without allergic conjunctivitis. Conclusion Refractive error may be a risk factor for allergic conjunctivitis.

Section: Introductionmentioning

confidence: 99%

Relationship between refraction and allergic conjunctivitis

Arimoto

et al. 2007

Eye

“…Cedar and cypress pollen have been identified as the major allergen sources of allergic conjunctivitis in spring. 4 However, little is known about causative allergens of allergic conjunctivitis in autumn.…”

Section: Introductionmentioning

confidence: 99%

Allergens in Japanese patients with allergic conjunctivitis in autumn

Yamagami

Amano

et al. 2004

Eye

Purpose The purpose of the current study is to evaluate the relation between various specific class E immunoglobulins (IgE) in the serum and allergic conjunctivitis in autumn. Methods Total IgE and specific IgE to 12 inhalant allergens were measured using the CAP system in 32 patients with allergic conjunctivitis in spring (spring group), 27 patients with allergic conjunctivitis in autumn (autumn group), and 40 healthy volunteers (control group). Results Specific IgE levels caused by house dust, Dermatophagoides pteronyssinus, and orchard grass were higher in the autumn group than in the spring group. The highest positivity rate for a specific allergen was 51.9% for house dust, followed by D. pteronyssinus (48.1%) in the autumn group, while the highest rate was 68.8 % for cedar pollen, followed by cypress pollen (59.4%) in the spring group. Correlation analysis showed that house dust was significantly correlated with animal epithelia, D. pteronyssinus, acarus, and Alternaria tenuis in the autumn group (Po0.001). Conclusions These results suggest that house dust is the main cause of allergic conjunctivitis during autumn. In spring, cypress pollen is the largest cause of allergic conjunctivitis, while indoor allergens such as house dust, animal epithelia, D. pteronyssinus, and acarus are not causative allergens in Japan. Eye (2005) 19, 995-999.

“…Our previous study demonstrated that the highest positivity rate for a specific allergen was 52.5% for cedar pollen, followed by cypress pollen at 37.5% in spring [1]. Cedar pollen has been identified as the major allergen that causes allergic conjunctivitis in spring [1,14]. However, no studies have investigated specific IgE levels in tear fluid of patients with allergic conjunctivitis during autumn.…”

Section: Introductionmentioning

confidence: 99%

“…In Japan, allergic conjunctivitis shows two peaks, which are in spring and in autumn. Our previous study demonstrated that the highest positivity rate for a specific allergen was 52.5% for cedar pollen, followed by cypress pollen at 37.5% in spring [1]. Cedar pollen has been identified as the major allergen that causes allergic conjunctivitis in spring [1,14].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Specific Tear IgE in Patients with Moderate-to-Severe Autumnal Allergic Conjunctivitis

Int Arch Allergy Immunol

Usui

Mori

et al. 2011

Self Cite

Background: Recently, a new commercial test for specific IgE based on immunochromatography (Immfast Check J1®) has been developed. We previously reported on the use of this kit for tear fluid samples during spring. In this study, we compared the level of specific IgE in tear fluid among patients with seasonal allergic conjunctivitis during spring or autumn and control subjects. Methods: A nonrandomized, cross-sectional study was conducted in patients with moderate-to-severe allergic conjunctivitis occurring in spring (n = 56, spring group) or autumn (n = 52, autumn group), as well as in age- and sex-matched healthy control subjects (n = 50, control group). Levels of specific IgE for cedar pollen, cat epithelium and Dermatophagoides pteronyssinus were measured in tear fluid with the Immfast Check J1. Results: Specific IgE scores for cedar pollen and D. pteronyssinus were significantly higher in the spring and autumn groups than in the control group (p < 0.0001). In the autumn group, the highest detection rate for a specific allergen was 96.2% for D. pteronyssinus, followed by cedar pollen (86.5%) and cat epithelium (25.5%). In the spring group, the highest detection rate was 98.3% for cedar pollen, followed by D. pteronyssinus (51.7%) and cat epithelium (19.0%). Conclusions: These results suggest that both house dust mite allergen and outdoor allergens such as cedar pollen can be causes of allergic conjunctivitis during both spring and autumn in Japan. The Immfast Check J1 provides rapid measurement of specific IgE in tear fluid, which allows easy diagnosis of allergic conjunctivitis in an outpatient setting.