Correlation study of Carcino Embryonic Antigen &amp; Cancer Antigen 15.3 in pretreated female breast cancer patients

Thriveni, Karuvaje; Krishnamoorthy, Lakshmi; Ramaswamy, Girija

doi:10.1007/bf02912882

Cited by 18 publications

(11 citation statements)

References 18 publications

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“…However, regression analysis showed low prediction. Our findings is the same as the study by Thriveni et al, 2007 that displayed regression analysis for predicting serum levels of CEA and it was also low in relation to stage, tumor size, node and tumor grade. They also displayed that serum CA15-3 levels were associated with advanced stages and larger tumor sizes (>5cm).…”

Section: Discussionsupporting

confidence: 89%

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Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Moazzezy¹,

Farahany²,

Oloomi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: CEA and CA 15.3 serum tumor markers are currently used in clinical practice for monitoring therapy. The aim of this study was to evaluate serum level of these markers among healthy females and invasive breast carcinoma (IBC) patients and to determine any relationships with clinicopathological factors. Materials and Methods: 60 Iranian females were enrolled in this study, 30 healthy and 30 diagnosed with breast cancer who had not received any preoperative chemotherapy or hormone therapy. Enzyme linked immunosorbent assays were used for the quantitative determination of the cancer associated antigens, CEA and MUC1 (CA15-3). Results: The serological levels of CEA and CA15-3 (5.0033±0.49 µg/L and 178.1667±15.11 U/ml) in the breast cancer patients were significantly higher (p=0.00) than the serum levels of normal controls (1.1237±0.11 µg/L and 21.13±3.058 U/ml). Regarding the CEA marker, a significant correlation with grade of tumor was shown. Furthermore, there was a low correlation between CA15-3 and CEA marker with correlation coefficient r=0.08. Conclusions: Collectively, markedly high levels of CEA and CA15-3 were found in our patients, pointing to their use as additional tools after clinical diagnosis.

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Section: Discussionsupporting

confidence: 89%

“…This marker plays the biological roles such as cell adhesion, immunity and it is responsible for metastasis (Thriveni et al, 2007). However, MUC1 is overexpressed and improperly glycosylated in malignant epithelial cells especially tumor cells (Barros et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Moazzezy¹,

Farahany²,

Oloomi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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show abstract

“…Uehara et al [ 6 ] and Atoum et al [ 11 ] found significant differences in CA15-3 expression levels in different stages of breast cancer. In addition, Thriveni et al found that serum CEA levels did not have any significant correlation in breast cancer patients prior to treatment [ 17 ]. Samy et al showed that preoperative serum levels of CEA of breast cancer patients were significantly higher compared with the levels of the control group [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Assessing Clinical Significance of Serum CA15-3 and Carcinoembryonic Antigen (CEA) Levels in Breast Cancer Patients: A Meta-Analysis

2016

Med Sci Monit

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BackgroundBreast cancer is the most common malignant cancer in women worldwide. The tumor markers Cancer Antigen 15-3 (CA15-3) and Carcinoembryonic Antigen (CEA) are frequently used for screening and monitoring breast cancer.Material/MethodsWe conducted a meta-analysis of 13 published case-control studies to assess the associations between serum levels of CA15-3 and CEA with breast cancer susceptibility, including 1179 cases and 493 controls. The analyses were performed on malignant tumor and benign tumor, as well as in different subgroups with respect to the patient ethnicities and clinical tumor stages.ResultsThis systematic review and meta-analysis of association studies shows that serum levels of CA15-3 and CEA are potential biomarkers for breast cancer monitoring. When stratified by clinical stage, we noticed that although malignant tumors in all stages show elevated levels of CA15-3, it is greatly associated with the tumor stage, as it increases as breast tumor stage worsens.ConclusionsThis study clarifies the inconsistent conclusions from multiple studies, and provides a precise estimation for clinical utility of 2 important biomarkers, CA15-3 and CEA, in breast cancer monitoring. Thus, our study will shed lights on the prognosis of breast cancer patients.

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“…But there are few reports concerning label-free detection of carcinoembryonic antigen (CEA) with an aptamer modified FBAR biosensor. CEA is one of the most widely used tumor markers in the clinical diagnosis of breast, colorectal, and lung cancer making monitoring of CEA very important for clinical tumor diagnoses [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Detection of a carcinoembryonic antigen using aptamer-modified film bulk acoustic resonators

Zheng¹,

Xiong²,

Guo³

et al. 2014

Materials Research Bulletin

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Correlation study of Carcino Embryonic Antigen & Cancer Antigen 15.3 in pretreated female breast cancer patients

Abstract: Carcino Embryonic Antigen (CEA) and Cancer Antigen15.3 (CA15.3)

Cited by 18 publications

References 18 publications

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Relationship between Preoperative Serum CA15-3 and CEA Levels and Clinicopathological Parameters in Breast Cancer

Assessing Clinical Significance of Serum CA15-3 and Carcinoembryonic Antigen (CEA) Levels in Breast Cancer Patients: A Meta-Analysis

Detection of a carcinoembryonic antigen using aptamer-modified film bulk acoustic resonators

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