Correlation of TSLP, IL-33, and CD4 + CD25 + FOXP3 + T regulatory (Treg) in pediatric asthma

Chauhan, Anil; Singh, Meenu; Agarwal, Amit; Paul, Nandini

doi:10.3109/02770903.2015.1026441

Cited by 43 publications

(32 citation statements)

References 30 publications

(34 reference statements)

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“…The data obtained correlate with the evidence of other researchers who did not find any statistically significant differences in serum TSLP levels in patients with asthma, SAFS and the ones without allergic reactions 26,27 . On the contrary, Chauhan et al 28 showed that high serum TSLP levels negatively correlated with the amount of Treg in children with asthma. The authors suggested TSLP as a biomarker to assess the severity of the inflammatory process of the respiratory tract in paediatric patients with asthma.…”

Section: Discussionsupporting

confidence: 87%

Diagnostic markers of allergic bronchopulmonary aspergillosis in patients with severe asthma

Kozlova

Фролова

Учеваткина

et al. 2020

Mycoses

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Summary Introduction Allergic bronchopulmonary aspergillosis (ABPA) is a lung disease in patients with asthma or cystic fibrosis (CF) caused by chronic allergic inflammation to Aspergillus spp. antigens. The role of different immunological mediators in the formation of chronic allergic inflammation in patients with ABPA is not sufficiently explored. Objectives This study aimed to investigate serum levels of thymic stromal lymphopoietin (TSLP), thymus and activated chemokine (TARC) as well as IL‐8 in patients with ABPA, and to evaluate their diagnostic and monitoring value in the disease. Patients/methods Prospective study included 21 patients with ABPA, 25 patients with severe asthma with fungal sensitisation (SAFS), 37 patients with severe asthma without fungal sensitisation (SAwFS), and 16 healthy people. In patients with ABPA, the serum levels of biomarkers were determined at baseline and after 12 weeks of itraconazole therapy. Serum levels of total IgE, Aspergillus‐fumigatus‐specific IgE, TSLP, TARC, IL‐8 were analysed by enzyme‐linked immunosorbent assay. Results In patients with ABPA we established significantly higher serum levels of TARC, IL‐8, total IgE, Aspergillus‐fumigatus‐specific IgE and peripheral blood eosinophil counts, compared to patients with SAwFS. There were no differences in TSLP levels between the examined groups of patients. Serum TARC levels were positively correlated to serum total IgE levels, A fumigatus‐specific IgE levels and peripheral blood eosinophil counts and also negatively correlated to lung function (FEV1). Longitudinally, serum levels TARC, total IgE and peripheral blood eosinophil counts significant decreased after treatment of ABPA. Conclusion Thymus and activated chemokine is a useful test in diagnosing and monitoring response to the antifungal treatment of patients with ABPA.

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Section: Discussionsupporting

confidence: 87%

Diagnostic markers of allergic bronchopulmonary aspergillosis in patients with severe asthma

Kozlova

Фролова

Учеваткина

et al. 2020

Mycoses

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“…No comorbidities or positive RAST had an impact on the serum TSLP level in our results when the AD diagnosis was present. Previous studies have revealed a significant upregulation of serum TSLP in asthmatic, but non‐AD children . In our study, this upregulation from asthma appears neutralized if AD is present.…”

Section: Discussionsupporting

confidence: 63%

TSLP, IL‐31, IL‐33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis

Nygaard

Hvid

Johansen

et al. 2016

Acad Dermatol Venereol

131

101

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The studied targets hold little potential as indicators of disease severity. The serum values of our targets show robustness against atopic comorbidities, allergies and changes in disease severity. This robustness strengthens their potential use in biomarker-based stratification and could be instrumental in identifying subgroups and predicting the possible benefit of therapeutic and prevention approaches.

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“…TSLP has been implicated as a mediator in the pathway of pediatric asthma, with higher plasma TSLP levels correlating with poor asthma control. 32 TSLP promotes basophil production and type 2 inflammation. 33 Infection of human airway epithelial cells with hMPV induced expression of TSLP, as well as leading to upregulation of IL-8 and IL-33, whereas TSLP blockade led to reduced lung inflammation, 34 indicating activation of the TSLP pathway initiating airway inflammation by hMPV acute infection.…”

Section: Human Bocavirusmentioning

confidence: 99%

Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma

Coverstone

Wang

Sumino

2019

Immunology and Allergy Clinics of North America

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With the dissemination of the use of sensitive molecular methods for viral detection, the opportunities to evaluate the role of respiratory viruses in acute and chronic respiratory illness has expanded in the past decade. Acute wheezing illnesses are common, especially in young children, and viral agents have been shown to be found in 60% to 100% of these episodes using these sensitive detection methods. 1-3 Multiple Disclosure: The authors have no conflicts to report. KEYWORDS Human metapneumovirus Bocavirus Influenza virus Wheezing Asthma KEY POINTSRespiratory viruses other than rhinovirus or respiratory syncytial virus can be associated with acute wheezing illness. Contribution to recurrent/wheezing is not well studied.Children with human metapneumovirus lower respiratory tract infection may have increased risk of subsequent recurrent wheezing over the several years after initial infection.

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Correlation of TSLP, IL-33, and CD4 + CD25 + FOXP3 + T regulatory (Treg) in pediatric asthma

Abstract: Children with asthma show elevated serum levels of TSLP, which correlated negatively with asthma control test and Treg cells. TSLP may be used as a biomarker for inflammation in pediatric asthma patients.

Cited by 43 publications

References 30 publications

Diagnostic markers of allergic bronchopulmonary aspergillosis in patients with severe asthma

Diagnostic markers of allergic bronchopulmonary aspergillosis in patients with severe asthma

TSLP, IL‐31, IL‐33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitis

Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma

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