Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma

Coverstone, Andrea M.; Wang, Leyao; Sumino, Kaharu

doi:10.1016/j.iac.2019.03.007

Cited by 39 publications

(38 citation statements)

References 75 publications

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“…Influenza viruses are another viral infections connected with asthma exacerbations (Coverstone et al, 2019). Asthma in the setting of influenza infection is associated with worse severity, higher risk of hospitalization, need for intensive care, and mortality (Ritchie et al, 2015).…”

Section: Virions Readily Colonize the Lungsmentioning

confidence: 99%

The Role of Lung and Gut Microbiota in the Pathology of Asthma

et al. 2020

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Section: Virions Readily Colonize the Lungsmentioning

confidence: 99%

The Role of Lung and Gut Microbiota in the Pathology of Asthma

et al. 2020

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“…Respiratory syncytial virus (RSV), human metapneumovirus (hMPV), rhinovirus (RV), and human parainfluenza virus (hPIV) represent four of the leading causes of respiratory tract infections in children and can lead to chronic wheezing and other pulmonary complications (17,18). Numerous studies have linked childhood RV infection with wheeze (2,19,20).…”

Section: Introductionmentioning

confidence: 99%

Insights Into Type I and III Interferons in Asthma and Exacerbations

et al. 2020

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Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year. Asthmatics display different phenotypes with distinct genetic components, environmental causes, and immunopathologic signatures, and are broadly characterized into type 2-high or type 2-low (non-type 2) endotypes by linking clinical characteristics, steroid responsiveness, and molecular pathways. Regardless of asthma severity and adequate disease management, patients may experience acute exacerbations of symptoms and a loss of disease control, often triggered by respiratory infections. The interferon (IFN) family represents a group of cytokines that play a central role in the protection against and exacerbation of various infections and pathologies, including asthma. Type I and III IFNs in particular play an indispensable role in the host immune system to fight off pathogens, which seems to be altered in both pediatric and adult asthmatics. Impaired IFN production leaves asthmatics susceptible to infection and with uncontrolled type 2 immunity, promotes airway hyperresponsiveness (AHR), and inflammation which can lead to asthma exacerbations. However, IFN deficiency is not observed in all asthmatics, and alterations in IFN expression may be independent of type 2 immunity. In this review, we discuss the link between type I and III IFNs and asthma both in general and in specific contexts, including during viral infection, co-infection, and bacterial/fungal infection. We also highlight several studies which examine the potential role for type I and III IFNs as asthma-related therapies.

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“…However, according to the epidemiological, clinical and experimental evidence, respiratory virus infections have been known to be the main inducers of acute exacerbations (AEs) in chronic lung disorders such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) (Ritchie et al 2017). RV, RSV, human metapneumovirus (HMPV), influenza virus, parainfluenza virus, adenovirus, human bocavirus (HBoV), CoV, and enterovirus are kinds of viruses which are in the association with acute wheezing illness and also asthma exacerbations (Coverstone et al 2019). RVs infection is associated with common cold characteristics, but it is not the only effect of RVs infection.…”

Section: Viral Respiratory Infectionsmentioning

confidence: 99%

Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19

et al. 2020

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Acute respiratory infections as one of the most common problems of healthcare systems also can be considered as an important reason for worldwide morbidity and mortality from infectious diseases. Coronaviruses are a group of well-known respiratory viruses that can cause acute respiratory infections. At the current state, the 2019 novel coronavirus is cited as the most worldwide problematic agent for the respiratory system. According to investigations, people with old age and underlying diseases are at higher risk of 2019 novel coronavirus infection. Indeed, they may show a severe form of the disease (with severe acute respiratory infections). Based on the promising role of cell therapy and regenerative medicine approaches in the treatment of several life-threatening diseases, it seems that applying cell-based approaches can also be a hopeful strategy for improving subjects with severe acute respiratory infections caused by the 2019 novel

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Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma

Cited by 39 publications

References 75 publications

The Role of Lung and Gut Microbiota in the Pathology of Asthma

The Role of Lung and Gut Microbiota in the Pathology of Asthma

Insights Into Type I and III Interferons in Asthma and Exacerbations

Auxiliary role of mesenchymal stem cells as regenerative medicine soldiers to attenuate inflammatory processes of severe acute respiratory infections caused by COVID-19

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