Correlation of total salivary secretory immunoglobulin A (SIgA) and mutans specific SIgA in children having different caries status

Pal, Soumen; Mitra, Malay; Mishra, Jiban; Saha, Subrata; Bhattacharya, Bhaswar B.

doi:10.4103/0970-4388.121831

Cited by 13 publications

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“…Various studies reported contradictory results on the correlation between sIgA and dental caries [17,20]. The same results were also found in this study.…”

supporting

confidence: 85%

“…Many researchers reported the correlation between sIgA and ECC cases, but it is still contradictory and inconsistent. Pal et al in their study reported that caries-free children had higher sIgA level than caries children [17], indicating the effective defense function of sIgA in caries-free individuals [18]. In contrast, Bagherian & Asadikaram (2012) [19] and Priyaet a.l (2013) [20] in their research reported different results, that children with caries had higher sIgA level compared to caries-free children.…”

mentioning

confidence: 98%

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Early Childhood Caries and its Correlation with Secretory Immunoglobulin A

Octiara¹,

Sutadi

Siregar³

et al. 2020

JBBBE

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The prevalence of Early Childhood Caries (ECC) was reported quite high in several countries, including Indonesia. Many studies had reported the relationship between sIgA level and ECC. However, the results obtained were not consistent due to the cross-sectional method used in examining sIgA. Therefore the purpose of this study was to analyze the occurence of ECC and sIgA level after 9 months of observation in children aged 2 years and below. The research was observational analytic with a cohort design for 9 months. The sample size was 68 caries-free children under 2 years old, who had at least 2 erupted primary upper incisors. Subjects were taken through purposive sampling from community health center in Medan. The sIgA examination was carried out 3 times, which were at the beginning of the month, at the 3rd and 9th month. The sIgA examination used the ELISA sandwich method and been read at 450 nm using a microplate reader. Caries examination was based on AAPD criteria. Data analysis used independent t-test, Spearman correlation, and longitudinal analysis used general estimating equation (linear) test. The significant value was defined as p<0.05. The results showed that caries-free children had higher sIgA level compared to children with ECC (p=0.003). Spearman correlation test results between the deft score and sIgA level showed a significant correlation (p = 0.006) with r value = -0.33.The higher the child's deft, the lower his/her sIgA level. It was concluded that caries-free children have effective sIgA defense functions in dealing with bacterial infections that cause caries so that salivary sIgA level were found to be higher in caries-free children compared to children with ECC.

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“…Various studies reported contradictory results on the correlation between sIgA and dental caries [17,20]. The same results were also found in this study.…”

supporting

confidence: 85%

mentioning

confidence: 98%

Early Childhood Caries and its Correlation with Secretory Immunoglobulin A

Octiara¹,

Sutadi

Siregar³

et al. 2020

JBBBE

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“…It can prevent the invasion and adhesion of pathogens, and can bind the corresponding antigen to inhibit bacterial proliferation and neutralize toxins, and can resist proteolytic enzymes. Protect the intestinal mucosa from being digested, and exert local anti-infection and anti-allergic effects ( Pal et al, 2013 ; Zhang J. et al, 2020 ).…”

Section: Effect Of Severe Acute Respiratory Syndrome Coronavirus 2 On Human Intestinal Tractmentioning

confidence: 99%

Herbal Medicine, Gut Microbiota, and COVID-19

Chen

et al. 2021

Front. Pharmacol.

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Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. The symptoms of COVID-19 range from mild flu-like symptoms, including cough and fever, to life threatening complications. There are still quite a number of patients with COVID-19 showed enteric symptoms including nausea, vomiting, and diarrhea. The gastrointestinal tract may be one of the target organs of SARS-CoV-2. Angiotensin converting enzyme 2 (ACE2) is the main receptor of SARS-CoV-2 virus, which is significantly expressed in intestinal cells. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Intestinal flora imbalance and endotoxemia may accelerate the progression of COVID-19. Many herbs have demonstrated properties relevant to the treatment of COVID-19, by supporting organs and systems of the body affected by the virus. Herbs can restore the structure of the intestinal flora, which may further modulate the immune function after SARS-CoV-2 infection. Regulation of intestinal flora by herbal medicine may be helpful for the treatment and recovery of the disease. Understanding the role of herbs that regulate intestinal flora in fighting respiratory virus infections and maintaining intestinal flora balance can provide new ideas for preventing and treating COVID-19.

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“…The results of the correlation between salivary s-IgA levels and the severity of dental caries were shown in Figure 5. Because of the limited number of studies on Downloaded from http://portlandpress.com/bioscirep/article-pdf/doi/10.1042/BSR20203208/899106/bsr-2020-3208.pdf by guest on 14 December 2020 differences in the severity of caries (only 9 studies were included) [21,25,5,33,36,38,39,41,46], and the heterogeneity in the studies was greater than 50% (I 2 >50%), a random-effects model was used (P <0.001). The results show that when comparing the salivary s-IgA levels of patients with high dental caries and patients with low dental caries ( Figure 5A), we found that the salivary s-IgA levels of patients with high dental caries were significantly lower than those of patients with low dental caries (SMD=-…”

Section: The Relationship Between the Saliva S-iga Level And The Sevementioning

confidence: 99%

“…with acceptable heterogeneity (I 2 =46%).The 22, 25, 27, 5,32,33,34,38,39,44,45,46,47,48 caries-free healthy control group included 265 study subjects and the caries group included 410 study subjects, and the combined meta-analysis of caries activity was performed at lower levels of s-IgA (SMD=-1.23, 95%CI: [-1.48; -0.99], P<0.001). In the sensitivity analysis, the removal of any individual study did not change the overall statistical significance, indicating that the meta-analysis was relatively stable and reliable (Figure 7).…”

mentioning

confidence: 99%

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

Gong

Wang

et al. 2020

Bioscience Reports

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Objective: To determine the levels of s-IgA in saliva of caries patients and healthy controls, and to evaluate whether there is a correlation between it and caries by meta-analysis. Methods: The PubMed, MEDLINE, EMBASE, Web of Science, Cochrane Library, Scopus, Chinese National Knowledge Infrastructure, Wanfang Data, Chongqing VIP database for Chinese Technical Periodicals, and China BioMedical Literature Services System databases were searched initially in April 2020 and repeated in August 2020. Two independent evaluators screened the literature and extracted the data according to the inclusion and exclusion criteria. R 4.0.2 software was used for meta-analysis. I2 test was commonly reflected the heterogeneity. Subgroup analysis and meta-regression analysis explore the sources of heterogeneity. Sensitivity analysis, funnel diagram, Begg’s rank correlation, and Egger’s linear regression were used to determine the possibility of publication bias. Results: The study was reviewed according to the project guidelines for optimal reporting (PRISMA) based on meta-analysis. A total of 30 case–control studies were included, with a total sample size of 1545 patients, including 918 caries patients and 627 healthy controls. Salivary s-IgA levels in caries patients were significantly lower than those in healthy controls (SMD = −0.49, 95%CI: [−0.94; −0.03], P=0.03). In addition, the results of subgroup analysis showed that the significant decrease of salivary s-IgA level was correlated with children patients, mixed dentition and Asian people (children: SMD = −0.45, 95%CI: [−0.89; −0.01], P=0.04; mixed dentition: SMD = −0.61, 95%CI: [−1.24; 0.03], P=0.06; Asian: SMD = −0.62, 95%CI: [−1.17; −0.08], P=0.02). The funnel diagram included in the study was symmetrically distributed, and the sensitivity analysis confirmed the robustness of the results. Conclusion: Salivary s-IgA levels in caries patients were significantly lower than in healthy controls. It has also been demonstrated that salivary s-IgA may be used as an alternative measure to identify subjects at risk of caries susceptibility, suggesting that salivary s-IgA may be a protective factor for dental caries.

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Correlation of total salivary secretory immunoglobulin A (SIgA) and mutans specific SIgA in children having different caries status

Abstract: The mutans specific SIgA and total SIgA has a weak, but negative correlation in children potentiating caries inhibitory action of SIgA.

Cited by 13 publications

References 0 publications

Early Childhood Caries and its Correlation with Secretory Immunoglobulin A

Early Childhood Caries and its Correlation with Secretory Immunoglobulin A

Herbal Medicine, Gut Microbiota, and COVID-19

Association between salivary s-IgA concentration and dental caries: an updated meta-analysis

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