Correlation of the Functional Activity of the Brain With Metabolic Parameters—iii*

Talwar, G. P.; Chopra, Sakshi; Goel, B. K.; D'Monte, B.

doi:10.1111/j.1471-4159.1966.tb03338.x

Cited by 50 publications

(2 citation statements)

References 4 publications

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“…Several researchers showed that electri cal and chemical stimuli or training stress in duce nucleic acid depletion in the brain (Rapport and Daginawala, 1970), and reduce the phosphate turnover of phosphoprotein and phospholipids (Ansell and Dolmen, 1957). Talwar et al (1966) suggest that RNA depletion caused by intensive stress reflects the inability of the synthesis to keep pace with RNA break down. Protein synthesis is consequently de pressed.…”

Section: Introductionmentioning

confidence: 99%

RNA and Protein Synthesis in Rat Brain during Exercise

Guarnieri¹,

Fussi²,

Fanelli³

et al. 1979

Pharmacology

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RNA and protein synthesis is noticeably depressed in the brain of swimming rats. Repeated oral administration of phosphothreonine, phosphoserine or arginine is susceptible of improving brain macromolecular synthesis. A parallel induction is observed on spermine and spermidine accumulation, particularly evident when arginine is used. The anti-fatigue effect of phosphorylated amino acids or arginine may be associated with the observed restoration of brain macromolecular synthesis via polyamine accumulation.

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Section: Introductionmentioning

confidence: 99%

RNA and Protein Synthesis in Rat Brain during Exercise

Guarnieri¹,

Fussi²,

Fanelli³

et al. 1979

Pharmacology

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“…The photic stimulation procedure lasted for 8–14 days. The onset time and duration of photic stimulation were chosen according to the previous reports of light therapy [ 7 – 13 , 21 , 41 – 43 ]. The experimental protocol of photic stimulation is illustrated in Fig 1B .…”

Section: Methodsmentioning

confidence: 99%

Rhythmical Photic Stimulation at Alpha Frequencies Produces Antidepressant-Like Effects in a Mouse Model of Depression

Kim

Khalid

et al. 2016

PLoS ONE

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Current therapies for depression consist primarily of pharmacological agents, including antidepressants, and/or psychiatric counseling, such as psychotherapy. However, light therapy has recently begun to be considered as an effective tool for the treatment of the neuropsychiatric behaviors and symptoms of a variety of brain disorders or diseases, including depression. One methodology employed in light therapy involves flickering photic stimulation within a specific frequency range. The present study investigated whether flickering and flashing photic stimulation with light emitting diodes (LEDs) could improve depression-like behaviors in a corticosterone (CORT)-induced mouse model of depression. Additionally, the effects of the flickering and flashing lights on depressive behavior were compared with those of fluoxetine. Rhythmical flickering photic stimulation at alpha frequencies from 9–11 Hz clearly improved performance on behavioral tasks assessing anxiety, locomotor activity, social interaction, and despair. In contrast, fluoxetine treatment did not strongly improve behavioral performance during the same period compared with flickering photic stimulation. The present findings demonstrated that LED-derived flickering photic stimulation more rapidly improved behavioral outcomes in a CORT-induced mouse model of depression compared with fluoxetine. Thus, the present study suggests that rhythmical photic stimulation at alpha frequencies may aid in the improvement of the quality of life of patients with depression.

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Cell growth in the lateral geniculate nucleus of kittens following the opening or closing of one eye

Wan

Cragg

1976

J of Comparative Neurology

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Closing one eye of kittens at 23 days after birth resulted in paler Nissl staining of the deprived cells in the lateral geniculate nucleus (LGN) that was detectable two days later. Differences between the two sides of the brain in mean cell area increased to a peak in binocular lamina A at 4--6 days after eyelid suture, and then fell to a trough at eight days before rising progressively to a higher level at 31 days. In lamina A1 the peak and trough were later. Opening one eye of kittens after 23 days of binocular closure from birth resulted in more intense Nissl staining of the stimulated cells in the LGN that was detectable four days later. The stimulated cells grew faster than the cells connected to the eye that remained closed, and this differential growth reached a peak at 17 days in binocular lamina A and at 21 days in lamina A1 before falling to a trough at 26--31 days. These results are compared with the time course of anabolic changes that have been measured in other neurons during stimulation. The coefficient of variation of cell size was computed and found to be slightly decreased for deprived cells and increased for stimulated cells. This suggests that larger cells changes their sizes proportionately more than smaller cells. The cells were measured in fronzen sections without shrinkage, and the areas are at least 25% larger than those reported previously after paraffin or celloidin embedding.

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Correlation of the Functional Activity of the Brain With Metabolic Parameters—iii*

Cited by 50 publications

References 4 publications

RNA and Protein Synthesis in Rat Brain during Exercise

RNA and Protein Synthesis in Rat Brain during Exercise

Rhythmical Photic Stimulation at Alpha Frequencies Produces Antidepressant-Like Effects in a Mouse Model of Depression

Cell growth in the lateral geniculate nucleus of kittens following the opening or closing of one eye

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